Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0084 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0084 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0084 | 0.0552 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0084 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Brugia malayi | Carboxylesterase family protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Onchocerca volvulus | 0.0084 | 0.0552 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0084 | 0.0552 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0084 | 0.0552 | 0.0552 |
Brugia malayi | Carboxylesterase family protein | 0.0084 | 0.0552 | 0.0552 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0084 | 0.0552 | 0.5 |
Onchocerca volvulus | 0.0084 | 0.0552 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 1 | 1 |
Onchocerca volvulus | 0.0084 | 0.0552 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0084 | 0.0552 | 0.0552 |
Brugia malayi | Carboxylesterase family protein | 0.0084 | 0.0552 | 0.0552 |
Brugia malayi | Carboxylesterase family protein | 0.05 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | carboxylesterase | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.05 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.05 | 1 | 1 |
Onchocerca volvulus | 0.0084 | 0.0552 | 0.5 | |
Onchocerca volvulus | 0.0084 | 0.0552 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.05 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.05 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.05 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.05 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.05 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.05 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.05 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.