TDR Targets

Basic information

Technical information

TDR Targets ID: 1751503
Name: 2-[2-[(2-ethyl-6-methylphenyl)amino]-2-oxoeth yl]sulfanyl-4,6-dimethyl-N-phenylpyridine-3-c arboxamide
MW: 433.566 | Formula: C25H27N3O2S
H donors: 2 H acceptors: 3 LogP: 5.36 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCc1cccc(c1NC(=O)CSc1nc(C)cc(c1C(=O)Nc1ccccc1)C)C
InChi: 1S/C25H27N3O2S/c1-5-19-11-9-10-16(2)23(19)28-21(29)15-31-25-22(17(3)14-18(4)26-25)24(30)27-20-12-7-6-8-13-20/h6-14H,5,15H2,1-4H3,(H,27,30)(H,28,29)
InChiKey: CKZKVTJXVGQRFB-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[2-[(2-ethyl-6-methyl-phenyl)amino]-2-oxo-ethyl]sulfanyl-4,6-dimethyl-N-phenyl-pyridine-3-carboxamide
2-[[2-[(2-ethyl-6-methylphenyl)amino]-2-oxoethyl]thio]-4,6-dimethyl-N-phenyl-3-pyridinecarboxamide
2-[[2-[(2-ethyl-6-methyl-phenyl)amino]-2-keto-ethyl]thio]-4,6-dimethyl-N-phenyl-nicotinamide
D276-0063
NCGC00117843-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0122	0.5855	0.7146
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0057	0.2513	0.2513
Echinococcus multilocularis	ecdysone induced protein 78C	0.0122	0.5855	0.7146
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.294	0.5021
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0044
Schistosoma mansoni	coup transcription factor	0.0122	0.5855	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0057	0.2513	0.2513
Onchocerca volvulus		0.0093	0.4351	0.4326
Loa Loa (eye worm)	hypothetical protein	0.0064	0.287	0.287
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0438	0.0535
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0885	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0122	0.5855	0.5855
Onchocerca volvulus		0.0057	0.2513	0.248
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0885	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0064	0.287	0.287
Schistosoma mansoni	phosphatidylserine receptor	0.0018	0.0438	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0057	0.2513	0.2513
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0044	0.0053
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0064	0.287	0.3503
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0122	0.5855	0.5837
Brugia malayi	Nuclear hormone receptor-like 1	0.0064	0.287	0.287
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0057	0.2513	0.3067
Brugia malayi	nuclear hormone receptor	0.0122	0.5855	0.5855
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0885	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.4351	0.4351
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8193	0.8193
Brugia malayi	jmjC domain containing protein	0.0066	0.294	0.294
Schistosoma mansoni	retinoic acid receptor RXR	0.0122	0.5855	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0057	0.2513	0.4291
Schistosoma mansoni	nuclear hormone receptor	0.0057	0.2513	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus granulosus	phd:f box containing protein	0.0018	0.0438	0.0535
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0122	0.5855	0.7146
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0885	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0438	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0057	0.2513	0.4291
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0093	0.4351	0.531
Onchocerca volvulus	Protein ultraspiracle homolog	0.0122	0.5855	0.5837
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0066	0.294	0.5021
Schistosoma mansoni	dishevelled	0.001	0.0044	0.0074
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0122	0.5855	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0122	0.5855	0.7146
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0066	0.294	0.3588
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0122	0.5855	0.5855
Echinococcus granulosus	ecdysone induced protein 78C	0.0122	0.5855	0.7146
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0044	0.0053
Echinococcus granulosus	muscleblind protein	0.0167	0.8193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0122	0.5855	0.5855
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.6453	0.6453
Brugia malayi	hypothetical protein	0.001	0.0044	0.0044
Schistosoma mansoni	jumonji domain containing protein	0.0066	0.294	0.5021
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus granulosus	L aminoadipate semialdehyde	0.0093	0.4351	0.531
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0122	0.5855	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0064	0.287	0.287
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Schistosoma mansoni	jumonji domain containing protein	0.0018	0.0438	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Brugia malayi	orphan nuclear receptor NR2E1	0.0057	0.2513	0.2513
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0122	0.5855	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0438	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0122	0.5855	0.7146
Entamoeba histolytica	hypothetical protein	0.0026	0.0885	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.6453	0.6453
Onchocerca volvulus	Bile acid receptor homolog	0.0122	0.5855	0.5837
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0057	0.2513	0.3067
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0044	0.0074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0122	0.5855	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0044	0.0053
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0122	0.5855	0.7146
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0044	0.0044
Brugia malayi	tailless protein	0.0057	0.2513	0.2513
Schistosoma mansoni	thyroid hormone receptor	0.0122	0.5855	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0057	0.2513	0.248
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0438	0.0438
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0018	0.0438	0.4689
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0122	0.5855	0.7146
Schistosoma mansoni	zinc finger protein	0.0057	0.2513	0.4291
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0122	0.5855	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0438	0.0438
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0044	0.0074
Brugia malayi	nuclear hormone receptor	0.0057	0.2513	0.2513
Echinococcus multilocularis	phd:f box containing protein	0.0018	0.0438	0.0535
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0122	0.5855	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.287	0.287
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.0885	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0057	0.2513	0.3067
Schistosoma mansoni	dep domain containing protein	0.001	0.0044	0.0074
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0057	0.2513	0.3067
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0122	0.5855	0.7146
Echinococcus granulosus	JmjC domain containing protein 4	0.0018	0.0438	0.0535
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.294	0.294
Onchocerca volvulus		0.0122	0.5855	0.5837
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0122	0.5855	0.5855
Echinococcus multilocularis	muscleblind protein 1	0.0167	0.8193	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0122	0.5855	0.5855
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0122	0.5855	0.7146
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0044	0.0053
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0202	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0438	0.0438
Brugia malayi	ecdysone receptor	0.0057	0.2513	0.2513
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0122	0.5855	0.7146
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0066	0.294	0.3588
Schistosoma mansoni	protein phosphatase 2C	0.0018	0.0438	0.0748
Brugia malayi	nuclear hormone receptor family member odr-7	0.0057	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0438	0.0438
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0044	0.0044
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0064	0.287	0.3503
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0122	0.5855	0.7146
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0057	0.2513	0.3067
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0057	0.2513	0.248
Brugia malayi	nuclear receptor RXR	0.0064	0.287	0.287
Schistosoma mansoni	phd/f-box containing protein	0.0018	0.0438	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0202	1	1
Loa Loa (eye worm)	DR-78	0.0057	0.2513	0.2513
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0057	0.2513	0.3067
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0122	0.5855	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0044	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Brugia malayi	Nuclear hormone receptor-like 1	0.0064	0.287	0.287
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Schistosoma mansoni	dishevelled	0.001	0.0044	0.0074
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0885	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0122	0.5855	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Brugia malayi	hypothetical protein	0.0057	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus multilocularis	jumonji domain containing 1A	0.0018	0.0438	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Brugia malayi	DIX domain containing protein	0.001	0.0044	0.0044
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0044	0.0053
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0064	0.287	0.4903
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0044	0.0074
Brugia malayi	jmjC domain containing protein	0.0018	0.0438	0.0438
Brugia malayi	conserved hypotetical protein	0.0057	0.2513	0.2513
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0885	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0057	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0057	0.2513	0.3067
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Brugia malayi	nuclear receptor NHR-88	0.0122	0.5855	0.5855
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0018	0.0438	0.0748
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0122	0.5855	0.7146
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0122	0.5855	0.5855
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0093	0.4351	0.4351
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0044	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0122	0.5855	0.5855
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0885	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0044
Brugia malayi	hypothetical protein	0.0064	0.287	0.287
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0122	0.5855	0.5855
Echinococcus multilocularis	JmjC domain containing protein 4	0.0018	0.0438	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0885	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0122	0.5855	0.5855
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0438	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0122	0.5855	0.5855
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0885	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0057	0.2513	0.3067
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0885	1
Brugia malayi	nuclear receptor NHR-88	0.0057	0.2513	0.2513
Schistosoma mansoni	thyroid hormone receptor	0.0122	0.5855	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0122	0.5855	0.7146
Brugia malayi	jmjC domain containing protein	0.0066	0.294	0.294
Brugia malayi	hypothetical protein	0.0064	0.287	0.287
Brugia malayi	Nuclear hormone receptor E75	0.0057	0.2513	0.2513
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0122	0.5855	0.5855
Schistosoma mansoni	nuclear receptor	0.0057	0.2513	0.4291
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0885	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.0885	0.5
Brugia malayi	Muscleblind-like protein	0.0167	0.8193	0.8193
Onchocerca volvulus		0.0057	0.2513	0.248
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0122	0.5855	0.7146
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0122	0.5855	0.5855
Schistosoma mansoni	RAR-like nuclear receptor	0.0122	0.5855	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0122	0.5855	0.5855
Schistosoma mansoni	nuclear hormone receptor	0.0057	0.2513	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus granulosus	lysine specific demethylase 6a	0.0018	0.0438	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0122	0.5855	0.5855
Echinococcus multilocularis	muscleblind protein	0.0167	0.8193	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0122	0.5855	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0044	0.0053
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0438	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0064	0.287	0.287
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0044	0.0053
Brugia malayi	ecdysteroid receptor	0.0122	0.5855	0.5855
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus multilocularis	FTZ F1 alpha	0.0122	0.5855	0.7146
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0122	0.5855	0.5855
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0122	0.5855	0.5855
Brugia malayi	photoreceptor-specific nuclear receptor	0.0122	0.5855	0.5855
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0122	0.5855	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2513	0.2513
Echinococcus multilocularis	nuclear receptor nhr 48	0.0057	0.2513	0.3067
Brugia malayi	nuclear receptor RXR	0.0057	0.2513	0.2513
Loa Loa (eye worm)	nuclear hormone receptor	0.0057	0.2513	0.2513
Loa Loa (eye worm)	hypothetical protein	0.0064	0.287	0.287
Echinococcus granulosus	lysine specific demethylase 5A	0.0066	0.294	0.3588
Echinococcus multilocularis	lysine specific demethylase 5A	0.0066	0.294	0.3588
Echinococcus granulosus	nuclear receptor nhr 48	0.0057	0.2513	0.3067
Brugia malayi	jmjC domain containing protein	0.0018	0.0438	0.0438
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0057	0.2513	0.4291
Brugia malayi	nuclear receptor NHR-67	0.0057	0.2513	0.2513
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0438	0.0535
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0122	0.5855	0.5855
Schistosoma mansoni	nuclear receptor	0.0057	0.2513	0.4291
Brugia malayi	Steroid receptor seven-up type 2	0.0122	0.5855	0.5855
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0044	0.0044
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0122	0.5855	0.7146
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0018	0.0438	0.4689
Brugia malayi	steroid hormone receptor	0.0122	0.5855	0.5855
Brugia malayi	jmjC domain containing protein	0.0018	0.0438	0.0438
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0044
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0064	0.287	0.4903
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0057	0.2513	0.3067
Brugia malayi	MH2 domain containing protein	0.0133	0.6453	0.6453
Schistosoma mansoni	nuclear hormone receptor	0.0122	0.5855	1
Brugia malayi	Nuclear hormone receptor E75	0.0057	0.2513	0.2513
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0122	0.5855	1
Brugia malayi	jmjC domain containing protein	0.0018	0.0438	0.0438
Echinococcus multilocularis	lysine specific demethylase 6a	0.0018	0.0438	0.0535
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0057	0.2513	0.3067
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0122	0.5855	0.5855
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0044	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0167	0.8193	0.8193
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0093	0.4351	0.7431
Echinococcus granulosus	jumonji domain containing 1A	0.0018	0.0438	0.0535
Brugia malayi	Nuclear hormone receptor-like 1	0.0122	0.5855	0.5855
Echinococcus granulosus	FTZ F1 alpha	0.0122	0.5855	0.7146
Brugia malayi	hypothetical protein	0.001	0.0044	0.0044

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2362749

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1751503