Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0463 | 0.0441 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0506 | 0.0415 |
Onchocerca volvulus | 0.03 | 0.9089 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0087 | 0.1843 | 0.1765 |
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 0.908 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0653 | 0.0396 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0069 | 0.1238 | 0.1062 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0514 | 0.0498 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0056 | 0.0806 | 0.057 |
Trichomonas vaginalis | A-type flavoprotein | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0305 | 0.0234 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0483 | 0.0202 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.03 | 0.9089 | 1 |
Treponema pallidum | ribonuclease Z | 0.03 | 0.9089 | 0.5 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.03 | 0.9089 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.3611 | 0.3549 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0463 | 0.0441 |
Mycobacterium leprae | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9089 | 1 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Possible hydrolase | 0.03 | 0.9089 | 1 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0463 | 0.0409 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Entamoeba histolytica | type A flavoprotein, putative | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Possible hydrolase | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.1992 | 0.1915 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0069 | 0.1238 | 0.1062 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.03 | 0.9089 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.1992 | 0.1915 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.2243 | 0.2389 |
Mycobacterium ulcerans | hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | hydrolase | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0653 | 0.0396 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.2192 | 0.2332 |
Mycobacterium ulcerans | hydrolase | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | zinc phosphodiesterase | 0.03 | 0.9089 | 0.908 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0463 | 0.0409 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0254 | 0.0177 |
Trypanosoma brucei | glyoxalase II | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0514 | 0.0466 |
Onchocerca volvulus | Putative hydrolase PNKD | 0.03 | 0.9089 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0041 | 0.0285 | 0.019 |
Entamoeba histolytica | type A flavoprotein, putative | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0625 | 0.0621 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.03 | 0.9089 | 0.908 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0254 | 0.0177 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0087 | 0.1843 | 0.16 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.2192 | 0.2332 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.2192 | 0.2118 |
Plasmodium vivax | unspecified product | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0305 | 0.0267 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 0.908 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0087 | 0.1843 | 0.1765 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4576 | 0.4982 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.03 | 0.9089 | 1 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 0.0463 | 0.0409 |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0653 | 0.0396 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.0463 | 0.0509 |
Leishmania major | hypothetical protein, conserved | 0.03 | 0.9089 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.0463 | 0.0441 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0305 | 0.0213 |
Leishmania major | metallo-beta-lactamase family-like protein | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.03 | 0.9089 | 1 |
Mycobacterium leprae | POSSIBLE HYDROLASE | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0087 | 0.1843 | 0.175 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.0463 | 0.0441 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0087 | 0.1843 | 0.175 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | zinc phosphodiesterase | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0305 | 0.0213 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0636 | 0.0376 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0087 | 0.1843 | 0.1926 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0069 | 0.124 | 0.1254 |
Echinococcus granulosus | ETHE1 protein | 0.03 | 0.9089 | 0.908 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0483 | 0.0202 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0074 | 0.1411 | 0.1258 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.0463 | 0.0441 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0069 | 0.124 | 0.0902 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0463 | 0.0441 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0064 | 0.0071 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0087 | 0.1843 | 0.0767 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0058 | 0.087 | 0.0642 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.2192 | 0.2118 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0087 | 0.1843 | 0.1926 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.03 | 0.9089 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0305 | 0.0213 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0087 | 0.1843 | 0.1943 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | hydrolase | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2192 | 0.2358 |
Mycobacterium leprae | Beta-lactamase-like protein | 0.03 | 0.9089 | 1 |
Echinococcus granulosus | zinc phosphodiesterase | 0.03 | 0.9089 | 0.908 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0305 | 0.0234 |
Trypanosoma brucei | cleavage and polyadenylation specificity factor subunit, putative | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.03 | 0.9089 | 0.908 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.03 | 0.9089 | 0.908 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0483 | 0.0202 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.03 | 0.9089 | 0.908 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0087 | 0.1843 | 0.1943 |
Mycobacterium leprae | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0481 | 0.0199 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.0463 | 0.0509 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0463 | 0.0409 |
Trypanosoma cruzi | glyoxalase II | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | zinc phosphodiesterase | 0.03 | 0.9089 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0463 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | ETHE1 protein | 0.03 | 0.9089 | 0.908 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0087 | 0.1843 | 0.16 |
Schistosoma mansoni | hypothetical protein | 0.03 | 0.9089 | 1 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.03 | 0.9089 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.03 | 0.9089 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0463 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0254 | 0.0177 |
Mycobacterium tuberculosis | Conserved protein | 0.03 | 0.9089 | 1 |
Leishmania major | cleavage and polyadenylation specificity factor, putative | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0463 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.03 | 0.9089 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.4576 | 0.4524 |
Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.4576 | 0.4524 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.03 | 0.9089 | 1 |
Leishmania major | metallo-beta-lactamase family protein-like protein | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Beta lactamase like protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0069 | 0.1238 | 0.1062 |
Brugia malayi | hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0087 | 0.1843 | 0.175 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.0463 | 0.0441 |
Trypanosoma brucei | metallo-beta-lactamase-like protein, putative | 0.03 | 0.9089 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0087 | 0.1843 | 0.1971 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0069 | 0.1238 | 0.1062 |
Mycobacterium ulcerans | hypothetical protein | 0.03 | 0.9089 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0636 | 0.0376 |
Brugia malayi | ethe1-prov protein | 0.03 | 0.9089 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.0463 | 0.0441 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0305 | 0.0267 |
Schistosoma mansoni | hypothetical protein | 0.03 | 0.9089 | 1 |
Trypanosoma cruzi | glyoxalase II | 0.03 | 0.9089 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0069 | 0.1238 | 0.1062 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0087 | 0.1843 | 0.1943 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.03 | 0.9089 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0481 | 0.0199 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.03 | 0.9089 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4576 | 0.4982 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0087 | 0.1843 | 0.1943 |
Trypanosoma cruzi | glyoxalase II | 0.03 | 0.9089 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0087 | 0.1843 | 0.0767 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.3611 | 0.3549 |
Trichomonas vaginalis | conserved hypothetical protein | 0.03 | 0.9089 | 1 |
Onchocerca volvulus | 0.0048 | 0.0514 | 0.0059 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0483 | 0.0202 |
Chlamydia trachomatis | ribonuclease Z | 0.03 | 0.9089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0463 | 0.0441 |
Onchocerca volvulus | 0.03 | 0.9089 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0254 | 0.0177 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0065 | 0.1085 | 0.0888 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0305 | 0.0213 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0481 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0463 | 0.0441 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (binding) | Binding constant of the compound towards Tachykinin receptor 2 using BANK as agonist on rabbit pulmonary artery tissues; NA is not active | ChEMBL. | 11591520 | |
pKB (binding) | = 6.98 | Binding constant towards tachykinin receptor 1 using ASMSP as agonist on rabbit pulmonary artery tissues. | ChEMBL. | 11591520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.