TDR Targets

Basic information

Technical information

TDR Targets ID: 175155
Name: 7-benzyl-8-(cyclohexylamino)-1,3-dimethylpuri ne-2,6-dione
MW: 367.445 | Formula: C20H25N5O2
H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cn1c(=O)n(C)c(=O)c2c1nc(n2Cc1ccccc1)NC1CCCCC1
InChi: 1S/C20H25N5O2/c1-23-17-16(18(26)24(2)20(23)27)25(13-14-9-5-3-6-10-14)19(22-17)21-15-11-7-4-8-12-15/h3,5-6,9-10,15H,4,7-8,11-13H2,1-2H3,(H,21,22)
InChiKey: YFWOBBMPMHHNHB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-benzyl-8-(cyclohexylamino)-1,3-dimethyl-purine-2,6-dione
8-(cyclohexylamino)-1,3-dimethyl-7-(phenylmethyl)purine-2,6-dione
7-benzyl-8-(cyclohexylamino)-1,3-dimethyl-xanthine
7-(benzyl)-8-(cyclohexylamino)-1,3-dimethyl-xanthine
STOCK2S-19673
ZINC00638030
Oprea1_131275
EU-0077021
Oprea1_625816
MLS000102928
SMR000015562
7-Benzyl-8-cyclohexylamino-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
BAS 03008117

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0146	0.0152	0.1024
Brugia malayi	Pleckstrin Homology Domain	0.0703	0.1025	0.1199
Echinococcus multilocularis	jumonji domain containing protein	0.0093	0.0069	0.0059
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.6433	1	1
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0146	0.0152	0.0142
Trypanosoma brucei	predicted C2 domain protein	0.0146	0.0152	0.1004
Brugia malayi	TAR-binding protein	0.0076	0.0043	0.0039
Brugia malayi	calpain 5	0.0146	0.0152	0.0168
Brugia malayi	phospholipase C homolog	0.0146	0.0152	0.0168
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Echinococcus granulosus	lysine specific demethylase 5A	0.0081	0.005	0.004
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0146	0.0152	0.0142
Brugia malayi	C1-like domain containing protein	0.0725	0.1059	0.124
Plasmodium falciparum	ferlin, putative	0.0146	0.0152	0.313
Echinococcus multilocularis	protein kinase c epsilon type	0.1845	0.2813	0.2806
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.0022	0.038
Echinococcus granulosus	serine:threonine protein kinase N2	0.0995	0.1482	0.1474
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0995	0.1482	1
Leishmania major	copine i-like protein	0.0146	0.0152	0.1738
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Brugia malayi	RNA binding protein	0.0076	0.0043	0.0039
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0146	0.0152	0.3025
Echinococcus multilocularis	synaptotagmin protein 4	0.0146	0.0152	0.0142
Trypanosoma brucei	DNA polymerase IV, putative	0.0063	0.0022	0.0126
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0146	0.0152	0.3025
Trichomonas vaginalis	chromobox protein, putative	0.0082	0.0051	0.0342
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0146	0.0152	0.0142
Echinococcus granulosus	peregrin	0.0067	0.0028	0.0018
Schistosoma mansoni	glut4 vesicle protein-related	0.0146	0.0152	0.0142
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Schistosoma mansoni	unc-13 (munc13)	0.0849	0.1253	0.1245
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0081	0.005	0.004
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0995	0.1482	0.1795
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Echinococcus multilocularis	peregrin	0.0067	0.0028	0.0018
Echinococcus granulosus	RNA directed DNA polymerase	0.4588	0.711	0.7108
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Trypanosoma brucei	synaptotagmin, putative	0.0146	0.0152	0.1004
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0973	0.1448	0.9767
Schistosoma mansoni	rho gtpase activating protein	0.0146	0.0152	0.0142
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	protein piccolo	0.0146	0.0152	0.0142
Echinococcus granulosus	calpain 5	0.0146	0.0152	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	protein kinase C mu	0.0725	0.1059	0.1051
Trypanosoma brucei	predicted C2 domain protein	0.0146	0.0152	0.1004
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0021	0.0358
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0703	0.1025	0.1238
Trypanosoma brucei	DNA polymerase IV, putative	0.0063	0.0022	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0193	0.1285
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0995	0.1482	0.1795
Echinococcus multilocularis	chromobox protein 1	0.0082	0.0051	0.0041
Trichomonas vaginalis	copine, putative	0.0146	0.0152	0.1024
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0725	0.1059	0.128
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Brugia malayi	diacylglycerol kinase	0.0703	0.1025	0.1199
Loa Loa (eye worm)	heterochromatin protein 1	0.0082	0.0051	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.0725	0.1059	0.1051
Echinococcus multilocularis	myoferlin	0.0146	0.0152	0.0142
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0146	0.0152	0.3025
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Schistosoma mansoni	hypothetical protein	0.0146	0.0152	0.0142
Echinococcus multilocularis	synaptotagmin	0.0146	0.0152	0.0142
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Loa Loa (eye worm)	jmjC domain-containing protein	0.0081	0.005	0.0049
Trypanosoma brucei	DNA polymerase IV, putative	0.0063	0.0022	0.0126
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0146	0.0152	0.0932
Echinococcus multilocularis	synaptotagmin	0.0146	0.0152	0.0142
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0063	0.0022	0.0148
Onchocerca volvulus		0.0146	0.0152	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0586	0.0841	0.1014
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0146	0.0152	0.0142
Schistosoma mansoni	hypothetical protein	0.0146	0.0152	0.0142
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0146	0.0152	0.1024
Giardia lamblia	PHD finger protein 15	0.0067	0.0028	0.1838
Echinococcus multilocularis	protein kinase c iota type	0.1699	0.2584	0.2577
Echinococcus multilocularis	RNA directed DNA polymerase	0.4588	0.711	0.7108
Loa Loa (eye worm)	hypothetical protein	0.0849	0.1253	0.1517
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.032	0.0424	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Onchocerca volvulus		0.0703	0.1025	0.8174
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0146	0.0152	0.0142
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0083	0.0053	0.0415
Brugia malayi	protein kinase C II.	0.1845	0.2813	0.3311
Schistosoma mansoni	hypothetical protein	0.0205	0.0243	0.0234
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Trypanosoma cruzi	C2 domain containing protein, putative	0.0146	0.0152	0.3025
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	CMGC family protein kinase	0.0083	0.0053	0.0357
Echinococcus multilocularis	unc 13 (munc13)	0.0849	0.1253	0.1245
Brugia malayi	Heterochromatin protein 1	0.0082	0.0051	0.0049
Entamoeba histolytica	diacylglycerol kinase, putative	0.0703	0.1025	0.6868
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0995	0.1482	0.1474
Schistosoma mansoni	hypothetical protein	0.0067	0.0028	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0063	0.0022	0.0012
Schistosoma mansoni	synaptotagmin 12	0.0146	0.0152	0.0142
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0146	0.0152	0.0174
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0146	0.0152	0.1004
Echinococcus granulosus	myotubularin protein 13	0.0703	0.1025	0.1016
Echinococcus granulosus	sodium channel protein	0.054	0.0769	0.076
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	chromobox protein	0.0082	0.0051	0.0041
Brugia malayi	MH2 domain containing protein	0.014	0.0142	0.0156
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0083	0.0053	0.0053
Loa Loa (eye worm)	copine family protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus multilocularis	extended synaptotagmin 2	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.006	0.0016	0.0009
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0083	0.0053	0.0044
Schistosoma mansoni	otoferlin	0.0146	0.0152	0.0142
Plasmodium vivax	ferlin, putative	0.0146	0.0152	0.313
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trypanosoma brucei	C2 domain containing protein, putative	0.0146	0.0152	0.1004
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0703	0.1025	0.1016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0219	0.0266	0.0257
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0995	0.1482	0.1474
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.054	0.0769	0.076
Entamoeba histolytica	hypothetical protein, conserved	0.0146	0.0152	0.0889
Echinococcus granulosus	synaptotagmin	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.5292	0.8212	1
Echinococcus multilocularis	synaptotagmin 15	0.0146	0.0152	0.0142
Schistosoma mansoni	diacylglycerol kinase theta	0.0703	0.1025	0.1016
Trypanosoma cruzi	synaptotagmin, putative	0.0146	0.0152	0.3025
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0146	0.0152	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.1845	0.2813	0.3417
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Leishmania major	c2 domain protein, putative	0.0146	0.0152	0.1738
Trypanosoma brucei	DNA polymerase eta, putative	0.009	0.0064	0.041
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0146	0.0152	0.0142
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0146	0.0152	0.0142
Schistosoma mansoni	serine/threonine protein kinase	0.0995	0.1482	0.1474
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0063	0.0022	0.0015
Trichomonas vaginalis	Proline-rich protein, putative	0.0146	0.0152	0.1024
Brugia malayi	Protein kinase domain containing protein	0.0995	0.1482	0.1739
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0043	0.0033
Echinococcus granulosus	unc 13 munc13	0.0849	0.1253	0.1245
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0067	0.0028	0.0018
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	ion channel nompc, putative	0.0146	0.0152	0.1024
Leishmania major	c2 domain protein, putative	0.0146	0.0152	0.1738
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0494	1
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0146	0.0152	0.0168
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0725	0.1059	0.124
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Schistosoma mansoni	protein kinase C mu	0.0703	0.1025	0.1016
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	copine 9	0.0146	0.0152	0.0142
Echinococcus granulosus	synaptotagmin 2	0.0146	0.0152	0.0142
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0995	0.1482	0.1474
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0703	0.1025	0.1238
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0146	0.0152	0.0142
Brugia malayi	protein kinase C3,putative	0.0725	0.1059	0.124
Echinococcus granulosus	synaptotagmin	0.0146	0.0152	0.0142
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0146	0.0152	0.1211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Trichomonas vaginalis	chromobox protein, putative	0.0082	0.0051	0.0342
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Echinococcus granulosus	protein kinase c eta type	0.0703	0.1025	0.1016
Plasmodium vivax	double C2-like domain-containing protein, putative	0.0146	0.0152	0.313
Brugia malayi	Variant SH3 domain containing protein	0.0146	0.0152	0.0168
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0083	0.0053	0.1012
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Echinococcus granulosus	NDR protein kinase	0.0995	0.1482	0.1474
Trypanosoma brucei	C2 domain containing protein, putative	0.0146	0.0152	0.1004
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0725	0.1059	0.128
Onchocerca volvulus	Alhambra homolog	0.0067	0.0028	0.022
Trypanosoma brucei	predicted C2 domain protein	0.0146	0.0152	0.1004
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0725	0.1059	0.1051
Echinococcus multilocularis	tumor protein p63	0.0408	0.0562	0.0553
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0083	0.0053	0.0336
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0146	0.0152	0.1024
Brugia malayi	Copine VIII	0.0146	0.0152	0.0168
Trichomonas vaginalis	CMGC family protein kinase	0.0083	0.0053	0.0357
Schistosoma mansoni	vav2	0.0703	0.1025	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0995	0.1482	0.1795
Schistosoma mansoni	unc-13 (munc13)	0.0849	0.1253	0.1245
Brugia malayi	Protein kinase c protein 2	0.546	0.8475	1
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Echinococcus granulosus	protein kinase c epsilon type	0.1845	0.2813	0.2806
Echinococcus granulosus	synaptotagmin	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.4588	0.711	0.8657
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.032	0.0424	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0849	0.1253	0.1245
Echinococcus granulosus	jumonji domain containing protein	0.0093	0.0069	0.0059
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.032	0.0424	1
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0053	0.0044
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.032	0.0424	1
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0146	0.0152	0.0142
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0703	0.1025	0.1016
Onchocerca volvulus		0.0146	0.0152	0.1211
Schistosoma mansoni	serine/threonine protein kinase	0.0725	0.1059	0.1051
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0995	0.1482	0.1474
Brugia malayi	Protein kinase domain containing protein	0.0725	0.1059	0.124
Schistosoma mansoni	hypothetical protein	0.0703	0.1025	0.1016
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	extended synaptotagmin 2	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0028	0.0022
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0083	0.0053	0.1012
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.6433	1	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0193	0.2294
Loa Loa (eye worm)	hypothetical protein	0.009	0.0064	0.0066
Trypanosoma cruzi	DNA polymerase eta, putative	0.009	0.0064	0.1235
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0224	0.5018
Onchocerca volvulus		0.0703	0.1025	0.8174
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0043	0.0033
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0146	0.0152	0.0142
Brugia malayi	p70 ribosomal S6 kinase beta	0.0995	0.1482	0.1739
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0193	0.3871
Toxoplasma gondii	diacylglycerol kinase, putative	0.0703	0.1025	0.6882
Brugia malayi	Bromodomain containing protein	0.0067	0.0028	0.0021
Loa Loa (eye worm)	jmjC domain-containing protein	0.0138	0.0139	0.0158
Echinococcus multilocularis	dna polymerase eta	0.009	0.0064	0.0055
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0995	0.1482	0.1474
Onchocerca volvulus		0.0146	0.0152	0.1211
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0146	0.0152	0.1004
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Trichomonas vaginalis	copine, putative	0.0146	0.0152	0.1024
Echinococcus multilocularis	active breakpoint cluster region	0.0146	0.0152	0.0142
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Schistosoma mansoni	protein kinase C	0.0849	0.1253	0.1245
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Echinococcus multilocularis	myotubularin protein 13	0.0703	0.1025	0.1016
Entamoeba histolytica	calcium-binding protein, putative	0.0146	0.0152	0.0889
Onchocerca volvulus		0.006	0.0016	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Brugia malayi	WW domain containing protein	0.0146	0.0152	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Entamoeba histolytica	protein kinase, putative	0.0995	0.1482	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0146	0.0152	0.0142
Echinococcus granulosus	Rac GTPase activating protein 1	0.0703	0.1025	0.1016
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0703	0.1025	0.1016
Brugia malayi	Copine family protein	0.0146	0.0152	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Echinococcus multilocularis	dna polymerase kappa	0.0063	0.0022	0.0012
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0146	0.0152	0.3025
Brugia malayi	Synaptotagmin protein 3	0.0146	0.0152	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0067	0.0028	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0703	0.1025	0.1238
Schistosoma mansoni	serine/threonine protein kinase	0.6433	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus multilocularis	copine 9	0.0146	0.0152	0.0142
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0703	0.1025	0.1016
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0146	0.0152	0.1024
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0995	0.1482	0.1474
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Trypanosoma brucei	hypothetical protein, conserved	0.0146	0.0152	0.1004
Entamoeba histolytica	DENN domain protein	0.0146	0.0152	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Toxoplasma gondii	PHD-finger domain-containing protein	0.0067	0.0028	0.0086
Entamoeba histolytica	hypothetical protein, conserved	0.0146	0.0152	0.0889
Trypanosoma brucei	protein kinase, putative	0.0083	0.0053	0.0336
Echinococcus multilocularis	serotonin receptor	0.0586	0.0841	0.0832
Trypanosoma cruzi	cAMP binding protein, putative	0.0146	0.0152	0.3025
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0494	1
Loa Loa (eye worm)	Nedd4-PD	0.0146	0.0152	0.0174
Onchocerca volvulus		0.0146	0.0152	0.1211
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0995	0.1482	0.1795
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0083	0.0053	0.0415
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0146	0.0152	0.0142
Brugia malayi	LD23056p	0.0146	0.0152	0.0168
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0146	0.0152	0.1004
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0016	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0995	0.1482	0.1474
Schistosoma mansoni	unc-13 (munc13)	0.0146	0.0152	0.0142
Schistosoma mansoni	serine/threonine protein kinase	0.1845	0.2813	0.2806
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0146	0.0152	0.0142
Brugia malayi	RhoGAP domain containing protein	0.0703	0.1025	0.1199
Echinococcus granulosus	N chimaerin	0.0703	0.1025	0.1016
Echinococcus granulosus	synaptotagmin 15	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0102	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	serine/threonine kinase	0.0995	0.1482	0.1474
Trichomonas vaginalis	copine, putative	0.0146	0.0152	0.1024
Echinococcus multilocularis	copine 9	0.0146	0.0152	0.0142
Echinococcus multilocularis	synaptotagmin 2	0.0146	0.0152	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Schistosoma mansoni	serine/threonine protein kinase	0.0995	0.1482	0.1474
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Plasmodium vivax	hypothetical protein, conserved	0.0146	0.0152	0.313
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0703	0.1025	0.1016
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0849	0.1253	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0586	0.0841	0.1014
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Echinococcus granulosus	copine 9	0.0146	0.0152	0.0142
Onchocerca volvulus	Putative cc2d1b protein	0.0146	0.0152	0.1211
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Echinococcus granulosus	chromobox protein 1	0.0082	0.0051	0.0041
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.0494	0.332
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.0494	0.6322
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Brugia malayi	diacylglycerol kinase	0.0703	0.1025	0.1199
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0043	0.0041
Schistosoma mansoni	fer-1-related	0.0146	0.0152	0.0142
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.4756	0.7374	0.8978
Toxoplasma gondii	Sma protein	0.0146	0.0152	0.0932
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0146	0.0152	0.0142
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0146	0.0152	0.0142
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0146	0.0152	0.0168
Echinococcus multilocularis	N chimaerin	0.0703	0.1025	0.1016
Entamoeba histolytica	diacylglycerol kinase, putative	0.0703	0.1025	0.6868
Brugia malayi	ImpB/MucB/SamB family protein	0.0063	0.0022	0.0015
Plasmodium falciparum	ferlin, putative	0.0146	0.0152	0.313
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0995	0.1482	0.1474
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0146	0.0152	0.0142
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.0142	0.0162
Schistosoma mansoni	chromobox protein	0.0082	0.0051	0.0041
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0043	0.0041
Echinococcus granulosus	Immunoglobulin E set	0.0146	0.0152	0.0142
Trichomonas vaginalis	DNA polymerase eta, putative	0.0063	0.0022	0.0148
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0043	0.0039
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0995	0.1482	0.1795
Toxoplasma gondii	hypothetical protein	0.0146	0.0152	0.0932
Echinococcus granulosus	tumor protein p63	0.0408	0.0562	0.0553
Plasmodium vivax	ferlin, putative	0.0146	0.0152	0.313
Loa Loa (eye worm)	PHD-finger family protein	0.0067	0.0028	0.0022
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0703	0.1025	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0995	0.1482	0.1795
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	neural cell expressed developmentally	0.0146	0.0152	0.0142
Entamoeba histolytica	protein kinase, putative	0.0995	0.1482	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0146	0.0152	0.313
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus multilocularis	neural cell expressed, developmentally	0.0146	0.0152	0.0142
Echinococcus multilocularis	geminin	0.0205	0.0243	0.0234
Schistosoma mansoni	synaptotagmin 12	0.0146	0.0152	0.0142
Brugia malayi	Synaptotagmin I	0.0146	0.0152	0.0168
Brugia malayi	Ras association domain family 1 isoform A	0.0703	0.1025	0.1199
Echinococcus granulosus	calcium activated potassium channel	0.0057	0.0012	0.0003
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0083	0.0053	0.1012
Entamoeba histolytica	protein kinase, putative	0.0995	0.1482	1
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0146	0.0152	0.0142
Trypanosoma brucei	C2 domain containing protein, putative	0.0146	0.0152	0.1004
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Brugia malayi	PHD-finger family protein	0.0067	0.0028	0.0021
Giardia lamblia	Kinase, CMGC MAPK	0.0083	0.0053	1
Echinococcus multilocularis	serine threonine protein kinase	0.573	0.8898	0.8897
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0146	0.0152	0.1024
Treponema pallidum	hypothetical protein	0.032	0.0424	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Toxoplasma gondii	ferlin family protein	0.0146	0.0152	0.0932
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0067	0.0028	0.0086
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0146	0.0152	0.1024
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.0022	0.038
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0043	0.0033
Trypanosoma brucei	hypothetical protein, conserved	0.0146	0.0152	0.1004
Echinococcus granulosus	dna polymerase kappa	0.0063	0.0022	0.0012
Brugia malayi	Synapse defective protein 1	0.0146	0.0152	0.0168
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Entamoeba histolytica	hypothetical protein	0.0703	0.1025	0.6868
Echinococcus multilocularis	synaptotagmin	0.0146	0.0152	0.0142
Loa Loa (eye worm)	synaptotagmin-1	0.0146	0.0152	0.0174
Brugia malayi	RhoGAP domain containing protein	0.0703	0.1025	0.1199
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0703	0.1025	0.1016
Echinococcus granulosus	active breakpoint cluster region	0.0146	0.0152	0.0142
Toxoplasma gondii	hypothetical protein	0.0146	0.0152	0.0932
Echinococcus multilocularis	protein piccolo	0.0146	0.0152	0.0142
Plasmodium falciparum	double C2-like domain-containing protein	0.0146	0.0152	0.313
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0146	0.0152	0.0174
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.0022	0.038
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0043	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0063	0.0022	0.0012
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.032	0.0424	0.5
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0146	0.0152	0.0889
Echinococcus multilocularis	calpain 5	0.0146	0.0152	0.0142
Loa Loa (eye worm)	raf kinase	0.0703	0.1025	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Schistosoma mansoni	mctp-related	0.0146	0.0152	0.0142
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0995	0.1482	0.1795
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0043	0.0033
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Brugia malayi	Hr1 repeat family protein	0.0995	0.1482	0.1739
Schistosoma mansoni	DNA polymerase eta	0.009	0.0064	0.0055
Brugia malayi	ImpB/MucB/SamB family protein	0.009	0.0064	0.0064
Trypanosoma brucei	unspecified product	0.0063	0.0022	0.0126
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Schistosoma mansoni	hypothetical protein	0.0146	0.0152	0.0142
Echinococcus granulosus	mitogen activated protein kinase	0.0083	0.0053	0.0044
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0043	0.0033
Echinococcus multilocularis	chromobox protein 1	0.0082	0.0051	0.0041
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Echinococcus granulosus	geminin	0.0205	0.0243	0.0234
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0063	0.0022	0.0012
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0146	0.0152	0.0174
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Echinococcus multilocularis	sodium channel protein	0.054	0.0769	0.076
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0063	0.0022	0.038
Schistosoma mansoni	copine	0.0146	0.0152	0.0142
Toxoplasma gondii	hypothetical protein	0.0146	0.0152	0.0932
Toxoplasma gondii	AGC kinase	0.0995	0.1482	1
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	synaptotagmin-like protein	0.0146	0.0152	0.0142
Brugia malayi	jmjC domain containing protein	0.0081	0.005	0.0047
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0081	0.005	0.004
Schistosoma mansoni	hypothetical protein	0.0205	0.0243	0.0234
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.4588	0.711	0.7108
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0146	0.0152	0.0142
Entamoeba histolytica	protein kinase, putative	0.0995	0.1482	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0083	0.0053	0.0044
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0146	0.0152	0.3025
Echinococcus multilocularis	synaptotagmin	0.0146	0.0152	0.0142
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0043	0.0041
Trypanosoma brucei	C2 domain containing protein, putative	0.0146	0.0152	0.1004
Echinococcus granulosus	protein kinase C gamma type	0.573	0.8898	0.8897
Echinococcus multilocularis	mitogen activated protein kinase	0.0083	0.0053	0.0044
Echinococcus multilocularis	lysine specific demethylase 5A	0.0081	0.005	0.004
Schistosoma mansoni	rabphilin-3a	0.0146	0.0152	0.0142
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0995	0.1482	0.1474
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0995	0.1482	0.1474
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0146	0.0152	0.0142
Schistosoma mansoni	jumonji domain containing protein	0.0174	0.0195	0.0186
Onchocerca volvulus		0.0146	0.0152	0.1211
Trypanosoma brucei	cAMP binding protein, putative	0.0146	0.0152	0.1004
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.0142	0.0162
Brugia malayi	jmjC domain containing protein	0.0219	0.0266	0.0303
Trichomonas vaginalis	CMGC family protein kinase	0.0083	0.0053	0.0357
Echinococcus multilocularis	serotonin receptor	0.0586	0.0841	0.0832
Entamoeba histolytica	protein kinase, putative	0.0168	0.0186	0.1125
Leishmania major	DNA polymerase eta, putative	0.009	0.0064	0.0562
Toxoplasma gondii	C2 domain-containing protein	0.0146	0.0152	0.0932
Onchocerca volvulus		0.0146	0.0152	0.1211
Brugia malayi	NEDD4.2	0.0146	0.0152	0.0168
Brugia malayi	Variant SH3 domain containing protein	0.0703	0.1025	0.1199
Brugia malayi	MAP kinase sur-1	0.0083	0.0053	0.0051
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0146	0.0152	0.0142
Brugia malayi	Protein kinase domain containing protein	0.0995	0.1482	0.1739
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Echinococcus multilocularis	intersectin 2	0.0146	0.0152	0.0142
Echinococcus granulosus	biogenic amine 5HT receptor	0.0586	0.0841	0.0832
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Entamoeba histolytica	hypothetical protein	0.0146	0.0152	0.0889
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0586	0.0841	0.0832
Trypanosoma cruzi	synaptotagmin, putative	0.0146	0.0152	0.3025
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Echinococcus multilocularis	calcium activated potassium channel	0.0057	0.0012	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Trichomonas vaginalis	synaptotagmin, putative	0.0146	0.0152	0.1024
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Echinococcus granulosus	synaptotagmin protein 4	0.0146	0.0152	0.0142
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.054	0.0769	1
Echinococcus multilocularis	synaptotagmin	0.0146	0.0152	0.0142
Echinococcus granulosus	myoferlin	0.0146	0.0152	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus granulosus	otoferlin	0.0146	0.0152	0.0142
Brugia malayi	Synapse defective protein 1	0.0146	0.0152	0.0168
Schistosoma mansoni	diacylglycerol kinase theta	0.0703	0.1025	0.1016
Schistosoma mansoni	rac gtpase activating protein	0.0703	0.1025	0.1016
Echinococcus granulosus	Diacylglycerol kinase theta	0.0703	0.1025	0.1016
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0063	0.0022	0.0012
Echinococcus multilocularis	protein kinase c eta type	0.0703	0.1025	0.1016
Toxoplasma gondii	Elicitor-responsive protein, putative	0.0146	0.0152	0.0932
Loa Loa (eye worm)	C2 domain-containing protein	0.0146	0.0152	0.0174
Brugia malayi	Protein kinase domain containing protein	0.0995	0.1482	0.1739
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	annexin VII, putative	0.0146	0.0152	0.1024
Schistosoma mansoni	hypothetical protein	0.0146	0.0152	0.0142
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0725	0.1059	0.1051
Brugia malayi	C2 domain containing protein	0.0146	0.0152	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0703	0.1025	0.1016
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0146	0.0152	0.0142
Schistosoma mansoni	serine/threonine protein kinase	0.0995	0.1482	0.1474
Brugia malayi	RhoGEF domain containing protein	0.0703	0.1025	0.1199
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0995	0.1482	0.1795
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0703	0.1025	0.1016
Onchocerca volvulus		0.0849	0.1253	1
Entamoeba histolytica	protein kinase, putative	0.0168	0.0186	0.1125
Leishmania major	phospholipase c-like protein	0.0146	0.0152	0.1738
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Schistosoma mansoni	hypothetical protein	0.0146	0.0152	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0219	0.0266	0.0257
Trichomonas vaginalis	copine, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	copine, putative	0.0146	0.0152	0.1024
Echinococcus granulosus	synaptotagmin	0.0146	0.0152	0.0142
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0083	0.0053	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0995	0.1482	1
Trichomonas vaginalis	CMGC family protein kinase	0.0083	0.0053	0.0357
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0043	0.0033
Echinococcus granulosus	chromobox protein 1	0.0082	0.0051	0.0041
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0224	0.5018
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0152	0.0174
Echinococcus granulosus	synaptotagmin	0.0146	0.0152	0.0142
Onchocerca volvulus		0.0146	0.0152	0.1211
Entamoeba histolytica	C2 domain protein, putative	0.0146	0.0152	0.0889
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0146	0.0152	0.1024
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Trichomonas vaginalis	conserved hypothetical protein	0.0146	0.0152	0.1024
Schistosoma mansoni	atypical protein kinase C	0.1699	0.2584	0.2577
Schistosoma mansoni	synaptotagmin	0.0146	0.0152	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Echinococcus granulosus	UNCoordinated family member unc 13	0.0146	0.0152	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0152	0.3025
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Echinococcus granulosus	PHD finger protein rhinoceros	0.0067	0.0028	0.0018
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0083	0.0053	0.1012
Echinococcus granulosus	protein kinase c iota type	0.1699	0.2584	0.2577
Leishmania major	hypothetical protein, conserved	0.0146	0.0152	0.1738
Echinococcus multilocularis		0.0146	0.0152	0.0142
Trypanosoma brucei	DNA polymerase kappa, putative	0.0063	0.0022	0.0126
Echinococcus granulosus	intersectin 2	0.0146	0.0152	0.0142
Echinococcus granulosus	dna polymerase eta	0.009	0.0064	0.0055
Entamoeba histolytica	C2 domain containing protein	0.0146	0.0152	0.0889
Echinococcus granulosus	raf serine:threonine protein kinase	0.0703	0.1025	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0703	0.1025	0.1238

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 54 %	Percentage inhibition against human phosphodiesterase type 5 isolated from corpus cavernosum at 100 nM.	ChEMBL.	12372521
Inhibition (binding)	= 54 %	Percentage inhibition against human phosphodiesterase type 5 isolated from corpus cavernosum at 100 nM.	ChEMBL.	12372521
Potency (functional)	0.3548 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.0418 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL320247
PubChem: 1146989

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 175155