TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 622.753 | Formula: C37H42N4O5
H donors: 3 H acceptors: 3 LogP: 5.3 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@@H](N1C[C@@H](C)[C@H](CN(Cc2ccc(cc2)Oc2ccccc2)C)Oc2c(CC1=O)cc(cc2)NC(=O)Nc1ccccc1)C
InChi: 1S/C37H42N4O5/c1-26-22-41(27(2)25-42)36(43)21-29-20-31(39-37(44)38-30-10-6-4-7-11-30)16-19-34(29)46-35(26)24-40(3)23-28-14-17-33(18-15-28)45-32-12-8-5-9-13-32/h4-20,26-27,35,42H,21-25H2,1-3H3,(H2,38,39,44)/t26-,27+,35+/m1/s1
InChiKey: DETSJJCDIRAXSN-RYOMNGFGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	paired box 8	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Brugia malayi	Pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Onchocerca volvulus		Get druggable targets OG5_139945	All targets in OG5_139945

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0132	0.0132
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Onchocerca volvulus		0.0042	0.0075	0.0072
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1359	0.5943	0.5924
Loa Loa (eye worm)	RGC/RGC protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	signal transduction protein lnk-related	0.1359	0.5943	0.5924
Onchocerca volvulus		0.1359	0.5943	0.5942
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1359	0.5943	0.5924
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0048	0.0122
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	expressed conserved protein	0.1359	0.5943	0.5924
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1359	0.5943	0.5943
Brugia malayi	Tyrosine-protein kinase abl-1	0.2269	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Brugia malayi	Variant SH3 domain containing protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0048	0.0122
Entamoeba histolytica	SH2 domain containing protein	0.1359	0.5943	0.5942
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0048	0.0487
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	serine/threonine RGC	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.091	0.3944	0.3915
Onchocerca volvulus		0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/CSK protein kinase	0.091	0.3944	0.3944
Trichomonas vaginalis	AGC family protein kinase	0.091	0.3944	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1359	0.5943	0.5924
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0048	0.0487
Brugia malayi	Protein kinase domain containing protein	0.1043	0.4538	0.4538
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.091	0.3944	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0048	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0042	0.0075	0.0027
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Echinococcus multilocularis	SH2 motif	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0004	0.001
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Brugia malayi	beta-lactamase	0.0036	0.0048	0.0048
Echinococcus multilocularis	tyrosine protein kinase HCK	0.091	0.3944	0.3915
Schistosoma mansoni	tyrosine kinase	0.006	0.0155	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2269	1	1
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1359	0.5943	0.5943
Echinococcus granulosus	ephrin type A receptor 4 A	0.091	0.3944	0.3915
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1359	0.5943	0.5924
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Schistosoma mansoni	ephrin receptor	0.091	0.3944	0.3915
Schistosoma mansoni	tyrosine kinase	0.097	0.4212	0.4184
Echinococcus granulosus	sodium:glucose cotransporter	0.0042	0.0075	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Brugia malayi	Sodium:solute symporter family protein	0.0042	0.0075	0.0075
Brugia malayi	hypothetical protein	0.091	0.3944	0.3944
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.0095	0.0047
Brugia malayi	Raf kinase	0.091	0.3944	0.3944
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1359	0.5943	0.5924
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus multilocularis	kinase suppressor of Ras 1	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK/FAK protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	geminin	0.0355	0.1472	0.1431
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1359	0.5943	0.5924
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Trypanosoma brucei	protein kinase, putative	0.091	0.3944	1
Brugia malayi	Receptor family ligand binding region containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0132	0.0132
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Brugia malayi	Protein kinase domain containing protein	0.2269	1	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0048	0.0048
Brugia malayi	Pax transcription factor protein 2	0.0291	0.1183	0.1183
Schistosoma mansoni	hypothetical protein	0.0037	0.0055	0.0007
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	N chimaerin	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0048	0.0048
Trypanosoma brucei	Pseudokinase, putative	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1359	0.5943	0.5924
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2269	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	tyrosine kinase	0.006	0.0155	0.0108
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2269	1	1
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0124	0.0076
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0048	0.0122
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	tyrosine kinase	0.2269	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	tyrosin kinase, putative	0.091	0.3944	0.3942
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0042	0.0075	0.0027
Entamoeba histolytica	ankyrin repeat protein	0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase csk	0.091	0.3944	0.3915
Schistosoma mansoni	patched 1	0.0046	0.0095	0.0047
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	SH2 domain containing protein 7	0.1359	0.5943	0.5924
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	natriuretic peptide receptor 1	0.091	0.3944	0.3915
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.0912	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1359	0.5943	0.5924
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.091	0.3944	0.3944
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0048	0.0487
Onchocerca volvulus		0.1359	0.5943	0.5942
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Onchocerca volvulus		0.0291	0.1183	0.118
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/RYK protein kinase	0.091	0.3944	0.3944
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Onchocerca volvulus		0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Leishmania major	hypothetical protein, conserved	0.091	0.3944	1
Brugia malayi	SH2 domain containing protein	0.2269	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.091	0.3944	0.3915
Plasmodium falciparum	protein kinase, putative	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Schistosoma mansoni	high-affinity choline transporter	0.0382	0.1589	0.1549
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Giardia lamblia	Kinase	0.091	0.3944	0.5
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0048	1
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1359	0.5943	0.5924
Echinococcus multilocularis	protein KINase family member (kin 25)	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Schistosoma mansoni	hypothetical protein	0.0355	0.1472	0.1431
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	high affinity choline transporter 1	0.0382	0.1589	0.1549
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	solute carrier family 5	0.0042	0.0075	0.0027
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.091	0.3944	0.3915
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Echinococcus multilocularis	NCK adaptor protein	0.1359	0.5943	0.5924
Echinococcus granulosus	SH2 motif	0.1359	0.5943	0.5924
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0042	0.0075	0.0191
Echinococcus granulosus	tyrosine protein kinase pr2	0.091	0.3944	0.3915
Plasmodium falciparum	tyrosine kinase-like protein	0.091	0.3944	1
Echinococcus granulosus	tumor protein p63	0.0371	0.1542	0.1501
Echinococcus granulosus	tyrosine protein kinase csk	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/DDR protein kinase	0.091	0.3944	0.3944
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0048	0.0487
Brugia malayi	SRC-1	0.2269	1	1
Schistosoma mansoni	hypothetical protein	0.0045	0.0087	0.0039
Onchocerca volvulus		0.091	0.3944	0.3942
Echinococcus granulosus	protein tyrosine kinase	0.091	0.3944	0.3915
Schistosoma mansoni	tyrosine kinase	0.006	0.0155	0.0108
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2269	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.0095	0.0047
Brugia malayi	Protein kinase domain containing protein	0.2269	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.091	0.3944	0.3944
Echinococcus multilocularis	FL cytokine receptor	0.091	0.3944	0.3915
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.091	0.3944	1
Entamoeba histolytica	hypothetical protein, conserved	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0054	0.013	0.013
Echinococcus multilocularis	solute carrier family 5	0.0042	0.0075	0.0027
Onchocerca volvulus		0.2269	1	1
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0048	0.0487
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0108	0.037	0.037
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Onchocerca volvulus		0.2269	1	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0095	0.0119
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Brugia malayi	Immunoglobulin I-set domain containing protein	0.091	0.3944	0.3944
Schistosoma mansoni	tensin-related	0.1359	0.5943	0.5924
Echinococcus granulosus	tyrosine protein kinase shark	0.2269	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.1043	0.4538	0.4538
Onchocerca volvulus		0.1359	0.5943	0.5942
Brugia malayi	protein-tyrosine kinase	0.2269	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Leishmania major	protein kinase, putative	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	SH2 motif	0.1359	0.5943	0.5924
Onchocerca volvulus		0.1359	0.5943	0.5942
Entamoeba histolytica	receptor protein kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	SRC-1	0.2269	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.091	0.3944	0.3915
Echinococcus granulosus	protein kinase	0.091	0.3944	0.3915
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Giardia lamblia	Kinase, NEK	0.091	0.3944	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1359	0.5943	0.5943
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.091	0.3944	0.3944
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2269	1	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0377	0.0331
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.1043	0.4538	0.4511
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	signal transduction protein lnk realted	0.1359	0.5943	0.5924
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.091	0.3944	0.3915
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0048	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	receptor protein kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.091	0.3944	0.3915
Brugia malayi	Variant SH3 domain containing protein	0.1359	0.5943	0.5943
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	hypothetical protein	0.0045	0.0087	0.0039
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.0095	0.0095
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.0055
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Echinococcus granulosus	N chimaerin	0.1359	0.5943	0.5924
Schistosoma mansoni	shc transforming protein	0.1359	0.5943	0.5924
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0004	0.001
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/ROR protein kinase	0.091	0.3944	0.3944
Trichomonas vaginalis	STE family protein kinase	0.091	0.3944	1
Onchocerca volvulus		0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1359	0.5943	0.5942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0095	0.0095
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	activated cdc42 kinase 1	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.2269	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0155	0.0577	0.0531
Schistosoma mansoni	hypothetical protein	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.0382	0.1589	0.1589
Loa Loa (eye worm)	TK/EPH protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0048	1
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1359	0.5943	0.5924
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2269	1	1
Echinococcus granulosus	SHC transforming protein 3	0.1359	0.5943	0.5924
Plasmodium vivax	tyrosine kinase-like protein, putative	0.091	0.3944	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0891	0.3858	0.3828
Echinococcus multilocularis	tensin	0.1359	0.5943	0.5924
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK/EGFR protein kinase	0.097	0.4212	0.4212
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Brugia malayi	SH2 domain containing protein	0.2269	1	1
Plasmodium falciparum	protein kinase, putative	0.091	0.3944	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0048	0.0048
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	SH2A	0.1359	0.5943	0.5924
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0108	0.037	0.0366
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Brugia malayi	Protein kinase domain containing protein	0.0983	0.427	0.427
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.091	0.3944	0.3944
Onchocerca volvulus		0.2269	1	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Plasmodium falciparum	protein kinase, putative	0.091	0.3944	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.091	0.3944	0.3942
Brugia malayi	Tyrosine-protein kinase PR2	0.091	0.3944	0.3944
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.091	0.3944	0.3944
Onchocerca volvulus		0.2269	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.091	0.3944	0.3915
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.037	0.0323
Onchocerca volvulus		0.091	0.3944	0.3942
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	heat shock protein 70	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0004	0.001
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.091	0.3944	0.3944
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.091	0.3944	0.3915
Echinococcus granulosus	SH2 domain containing protein 7	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	serine/threonine protein kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	tensin	0.1359	0.5943	0.5924
Loa Loa (eye worm)	protein kinase domain-containing protein	0.091	0.3944	0.3944
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Echinococcus multilocularis		0.1359	0.5943	0.5924
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1359	0.5943	0.5943
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Brugia malayi	C-terminal src kinase protein 1	0.091	0.3944	0.3944
Echinococcus multilocularis	raf serine:threonine protein kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0004	0.0004
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Entamoeba histolytica	tyrosin kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2269	1	1
Schistosoma mansoni	tensin	0.1359	0.5943	0.5924
Brugia malayi	Tensin	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	c src tyrosine kinase	0.2269	1	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase pr2	0.091	0.3944	0.3915
Loa Loa (eye worm)	SH2 domain-containing protein	0.1359	0.5943	0.5943
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0004	0.0004
Brugia malayi	hypothetical protein	0.091	0.3944	0.3944
Brugia malayi	Sex muscle abnormal protein 5	0.1359	0.5943	0.5943
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/Met protein kinase	0.091	0.3944	0.3944
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TK protein kinase	0.2269	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1359	0.5943	0.5924
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.091	0.3944	1
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0132	0.0132
Schistosoma mansoni	adapter molecule crk	0.1359	0.5943	0.5924
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2269	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	vav2	0.1359	0.5943	0.5924
Entamoeba histolytica	tyrosin kinase, putative	0.091	0.3944	0.3942
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Schistosoma mansoni	serine/threonine protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.091	0.3944	0.3915
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0055	0.0055
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0048	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1359	0.5943	0.5924
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0048	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.091	0.3944	0.3915
Schistosoma mansoni	ephrin receptor	0.091	0.3944	0.3915
Brugia malayi	CHE-14 protein	0.0046	0.0095	0.0095
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2269	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0075	0.0075
Onchocerca volvulus		0.1359	0.5943	0.5942
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Onchocerca volvulus		0.1359	0.5943	0.5942
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0048	0.0122
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0004	0.0004
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2269	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.1359	0.5943	0.5924
Brugia malayi	Protein kinase domain containing protein	0.2269	1	1
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus granulosus	tyrosine protein kinase csk	0.091	0.3944	0.3915
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1359	0.5943	0.5943
Schistosoma mansoni	inositol transporter	0.0042	0.0075	0.0027
Echinococcus multilocularis	c src tyrosine kinase	0.2269	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2269	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.037	0.0323
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	activated cdc42 kinase 1	0.091	0.3944	0.3915
Onchocerca volvulus		0.091	0.3944	0.3942
Echinococcus granulosus	tyrosine kinase	0.2269	1	1
Echinococcus multilocularis	insulin receptor	0.1043	0.4538	0.4511
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Brugia malayi	beta-lactamase family protein	0.0036	0.0048	0.0048
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.091	0.3944	0.3944
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1359	0.5943	0.5942
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0048	0.0122
Schistosoma mansoni	sodium/solute symporter	0.0042	0.0075	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Onchocerca volvulus		0.091	0.3944	0.3942
Schistosoma mansoni	hypothetical protein	0.0045	0.0087	0.0039
Echinococcus granulosus	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.091	0.3944	0.3915
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1359	0.5943	0.5943
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0048	1
Loa Loa (eye worm)	hypothetical protein	0.2269	1	1
Plasmodium vivax	protein kinase, putative	0.091	0.3944	1
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.091	0.3944	0.3915
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1359	0.5943	0.5943
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase	0.091	0.3944	0.3915
Onchocerca volvulus		0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2269	1	1
Loa Loa (eye worm)	STAT protein	0.1359	0.5943	0.5943
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.091	0.3944	0.3942
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	SH2 motif	0.1359	0.5943	0.5924
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.091	0.3944	1
Echinococcus granulosus	tyrosine protein kinase csk	0.091	0.3944	0.3915
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0048	0.0487
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Giardia lamblia	Protein 21.1	0.091	0.3944	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1359	0.5943	0.5942
Plasmodium falciparum	tyrosine kinase-like protein	0.091	0.3944	1
Schistosoma mansoni	tyrosine protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2269	1	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trichomonas vaginalis	CAMK family protein kinase	0.091	0.3944	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	tyrosine kinase	0.097	0.4212	0.4184
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Echinococcus multilocularis	tyrosine protein kinase shark	0.2269	1	1
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Echinococcus granulosus	tyrosine protein kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	SH2 domain-containing protein	0.1359	0.5943	0.5943
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	NCK adaptor protein	0.1359	0.5943	0.5924
Loa Loa (eye worm)	TK/ABL protein kinase	0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.097	0.4212	0.4184
Echinococcus granulosus	kinase suppressor of Ras 1	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase csk	0.091	0.3944	0.3915
Echinococcus multilocularis	expressed conserved protein	0.0102	0.0341	0.0294
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2269	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0214	0.0214
Echinococcus granulosus	epidermal growth factor receptor	0.097	0.4212	0.4184
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Echinococcus multilocularis	activin receptor type	0.091	0.3944	0.3915
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Schistosoma mansoni	growth factor receptor-bound protein	0.1359	0.5943	0.5924
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2269	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.091	0.3944	0.3915
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus granulosus	SH2 motif	0.1359	0.5943	0.5924
Brugia malayi	Furin-like cysteine rich region family protein	0.097	0.4212	0.4212
Echinococcus granulosus	integrin linked protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	tyrosine protein kinase Blk	0.2269	1	1
Brugia malayi	RhoGAP domain containing protein	0.1359	0.5943	0.5943
Brugia malayi	hypothetical protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	protein tyrosine kinase, putative	0.091	0.3944	1
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.091	0.3944	0.3915
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.091	0.3944	0.3915
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2269	1	1
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Brugia malayi	SH2 domain containing protein	0.1359	0.5943	0.5943
Schistosoma mansoni	tensin-related	0.1359	0.5943	0.5924
Schistosoma mansoni	tyrosine kinase	0.1043	0.4538	0.4511
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Brugia malayi	Immunoglobulin I-set domain containing protein	0.091	0.3944	0.3944
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Schistosoma mansoni	hypothetical protein	0.1359	0.5943	0.5924
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.091	0.3944	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2269	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.091	0.3944	1
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	tumor protein p63	0.0371	0.1542	0.1501
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1359	0.5943	0.5943
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	serine/threonine kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	RGC/RGC protein kinase	0.091	0.3944	0.3944
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Schistosoma mansoni	GTPase activating protein	0.1359	0.5943	0.5924
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0004	0.0004
Onchocerca volvulus		0.091	0.3944	0.3942
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.091	0.3944	1
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Onchocerca volvulus		0.0036	0.0048	0.0044
Schistosoma mansoni	suppressor of cytokine signaling	0.1359	0.5943	0.5924
Brugia malayi	Niemann-Pick C1 protein precursor	0.0108	0.037	0.037
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Echinococcus multilocularis	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2269	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.091	0.3944	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.091	0.3944	0.3915
Echinococcus granulosus	growth factor receptor bound protein 2	0.1359	0.5943	0.5924
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Brugia malayi	Variant SH3 domain containing protein	0.1359	0.5943	0.5943
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Trichomonas vaginalis	protein kinase atn1, putative	0.091	0.3944	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2269	1	1
Entamoeba histolytica	ankyrin repeat protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/ACK protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2269	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.091	0.3944	0.3915
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2269	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1359	0.5943	0.5943
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0042	0.0075	0.0027
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0042	0.0075	0.0027
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus granulosus	tyrosine kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2269	1	1
Brugia malayi	integrin-linked kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/FER protein kinase	0.2269	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.097	0.4212	0.4184
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Plasmodium vivax	tyrosine kinase-like protein, putative	0.091	0.3944	1
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.013	0.0082
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	cysteine surface protein, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0141	0.0141
Mycobacterium ulcerans	lipase LipD	0.0036	0.0048	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Onchocerca volvulus		0.0036	0.0048	0.0044
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.1359	0.5943	0.5943
Echinococcus multilocularis	integrin linked protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	natriuretic peptide receptor 1	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	geminin	0.0355	0.1472	0.1431
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.091	0.3944	0.3944
Trypanosoma cruzi	protein kinase, putative	0.091	0.3944	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2269	1	1
Echinococcus multilocularis	protein patched	0.0046	0.0095	0.0047
Entamoeba histolytica	tyrosin kinase, putative	0.091	0.3944	0.3942
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1359	0.5943	0.5943
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.091	0.3944	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0004	0.0004
Echinococcus multilocularis	transfer RNA-Thr	0.091	0.3944	0.3915
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.091	0.3944	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0004	0.0004
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.091	0.3944	1
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Schistosoma mansoni	nck2/grb4	0.1359	0.5943	0.5924
Echinococcus granulosus	tyrosine protein kinase Srms	0.2269	1	1
Onchocerca volvulus		0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	activin receptor type	0.091	0.3944	0.3915
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0048	0.0487
Echinococcus multilocularis	epidermal growth factor receptor	0.097	0.4212	0.4184
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.091	0.3944	0.3942
Brugia malayi	GH02984p	0.0382	0.1589	0.1589
Onchocerca volvulus		0.2269	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.091	0.3944	0.3944
Brugia malayi	bone morphogenetic protein type 1 receptor	0.091	0.3944	0.3944
Echinococcus granulosus	insulin receptor	0.1043	0.4538	0.4511
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1359	0.5943	0.5924
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0048	0.0487
Echinococcus multilocularis	tensin	0.1359	0.5943	0.5924
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Onchocerca volvulus		0.0054	0.013	0.0126
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Loa Loa (eye worm)	RGC/RGC protein kinase	0.091	0.3944	0.3944
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2269	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.091	0.3944	0.3944
Schistosoma mansoni	tensin	0.1359	0.5943	0.5924
Leishmania major	protein kinase, putative	0.091	0.3944	1
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0155	0.0577	0.0531
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2269	1	1
Echinococcus granulosus	expressed conserved protein	0.0102	0.0341	0.0294
Echinococcus granulosus	tensin	0.1359	0.5943	0.5924
Toxoplasma gondii	STE kinase	0.091	0.3944	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.1043	0.4538	0.4511
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.091	0.3944	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.0095	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	hypothetical protein	0.0355	0.1472	0.1431
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0048
Echinococcus multilocularis	protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0042	0.0075	0.0027
Echinococcus multilocularis	protein kinase	0.091	0.3944	0.3915
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Onchocerca volvulus		0.0036	0.0048	0.0044
Brugia malayi	ephrin receptor 1 precursor	0.091	0.3944	0.3944
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2269	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.091	0.3944	0.3942
Echinococcus granulosus	tyrosine protein kinase HCK	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	hypothetical protein	0.1359	0.5943	0.5924
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2269	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2269	1	1
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Brugia malayi	hypothetical protein	0.2269	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1359	0.5943	0.5924
Echinococcus granulosus	epidermal growth factor receptor	0.097	0.4212	0.4184
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Loa Loa (eye worm)	TK/FER protein kinase	0.091	0.3944	0.3944
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.091	0.3944	0.3915
Toxoplasma gondii	protein kinase	0.091	0.3944	1
Entamoeba histolytica	protein kinase domain containing protein	0.091	0.3944	0.3942
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.091	0.3944	0.3944
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0042	0.0075	0.0027
Schistosoma mansoni	serine/threonine protein kinase	0.091	0.3944	0.3915
Echinococcus granulosus	retinal guanylyl cyclase 2	0.091	0.3944	0.3915
Echinococcus granulosus	tyrosine kinase	0.2269	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1359	0.5943	0.5943
Brugia malayi	Protein kinase domain containing protein	0.091	0.3944	0.3944
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1359	0.5943	0.5924
Trypanosoma cruzi	protein kinase, putative	0.091	0.3944	1
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1359	0.5943	0.5943
Schistosoma mansoni	protein tyrosine kinase	0.091	0.3944	0.3915
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0132	0.0132
Entamoeba histolytica	protein kinase, putative	0.1359	0.5943	0.5942
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Giardia lamblia	Kinase, NEK	0.091	0.3944	0.5
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.1183	0.1183
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1359	0.5943	0.5924
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0048	0.0487
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1359	0.5943	0.5924
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.097	0.4212	0.4184
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Echinococcus granulosus	hypothetical protein	0.1359	0.5943	0.5924
Entamoeba histolytica	hypothetical protein	0.091	0.3944	0.3942
Trichomonas vaginalis	TK family protein kinase	0.091	0.3944	1
Echinococcus granulosus	high affinity choline transporter 1	0.0382	0.1589	0.1549
Schistosoma mansoni	hypothetical protein	0.0045	0.0087	0.0039
Schistosoma mansoni	tyrosine kinase	0.091	0.3944	0.3915
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Schistosoma mansoni	inositol transporter	0.0042	0.0075	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Echinococcus multilocularis	SHC transforming protein 3	0.1359	0.5943	0.5924
Echinococcus granulosus	receptor type guanylyl cyclase	0.091	0.3944	0.3915
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.1043	0.4538	0.4511
Schistosoma mansoni	protein kinase	0.091	0.3944	0.3915
Echinococcus multilocularis	tyrosine protein kinase csk	0.091	0.3944	0.3915
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0048	0.0487
Entamoeba histolytica	protein kinase, putative	0.091	0.3944	0.3942
Schistosoma mansoni	tyrosine kinase	0.2269	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.091	0.3944	0.3942
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2269	1	1
Loa Loa (eye worm)	hypothetical protein	0.091	0.3944	0.3944
Trichomonas vaginalis	TKL family protein kinase	0.091	0.3944	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0048	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 9.84 uM	PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2358640

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1752293