Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0588 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0.0347 | 0.0347 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 0.0513 | 0.047 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.0268 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 0.0513 | 0.0513 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 0.0513 | 0.0513 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0854 | 0.0854 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.0169 | 0.1335 |
Onchocerca volvulus | 0.0037 | 0.0347 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.002 | 0.0037 | 0.0037 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.0169 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.0169 | 0.0169 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0.0347 | 0.0347 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 0.0169 | 0.0124 |
Echinococcus multilocularis | geminin | 0.0177 | 0.2802 | 0.2802 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0854 | 0.0854 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0.0347 | 0.0347 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.0308 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0531 | 0.0531 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0153 | 0.0109 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0045 | 0.0045 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0169 | 0.0169 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0531 | 0.0531 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0153 | 0.0109 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0045 | 0.0045 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0351 | 0.0351 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0045 | 0.0045 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0351 | 0.0351 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.0268 | 0.0224 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0037 | 0.0037 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0531 | 0.0531 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0045 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0045 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.0513 | 0.0513 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.0308 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0169 | 0.0124 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0347 | 0.0347 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.0169 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0045 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0531 | 0.0531 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.0169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.0169 | 0.0169 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 0.0513 | 0.047 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0531 | 0.0531 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0153 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.0268 | 0.0224 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0588 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2802 | 0.2802 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | geminin | 0.0177 | 0.2802 | 0.2802 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | ecdysteroid receptor | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0045 | 0.0045 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0347 | 0.0347 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0045 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0153 | 0.0153 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.0308 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.002 | 0.0037 | 0.0037 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0531 | 0.0531 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.0308 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0351 | 0.0351 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0531 | 0.0531 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0524 | 0.8878 | 0.8878 |
Brugia malayi | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0854 | 0.0854 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0504 | 0.8532 | 0.8532 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.034 | 0.5658 | 0.5658 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.2802 | 0.2802 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0153 | 0.0153 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0531 | 0.0531 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0854 | 0.0854 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0.0347 | 0.0347 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0045 | 0.0045 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0045 | 0.0045 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0854 | 0.0854 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0351 | 0.0351 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | nuclear receptor RXR | 0.002 | 0.0037 | 0.0037 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0351 | 0.0351 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0037 | 0.0037 |
Echinococcus granulosus | transcription factor Dp 1 | 0.034 | 0.5658 | 0.5658 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0347 | 0.0347 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0169 | 0.0124 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0045 | 0.0045 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 0.0513 | 0.047 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0153 | 0.0109 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0.0347 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0037 | 0.0037 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0588 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0588 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0588 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0588 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0169 | 0.0169 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0854 | 0.0854 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0524 | 0.8878 | 0.8878 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.0123 | 0.0123 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0347 | 0.0347 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0037 | 0.0347 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0.0347 | 0.0347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0854 | 0.0854 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0531 | 0.0531 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0347 | 0.0347 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0347 | 0.0347 |
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0854 | 0.0854 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0347 | 0.0347 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.002 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0347 | 0.0347 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0854 | 0.0854 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.002 | 0.0037 | 0.0037 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0169 | 0.0124 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0037 | 0.0037 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0.0347 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.