Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1286 | 0.1504 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3073 | 0.3973 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1286 | 0.1504 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.1861 | 0.2502 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.0533 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0128 | 0.7436 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1924 | 0.2385 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1924 | 0.1761 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0074 | 0.3857 | 0.3733 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0026 | 0.0638 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0638 | 0.0608 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.1861 | 0.2298 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3073 | 0.3973 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1924 | 0.1761 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3073 | 0.4133 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0992 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1286 | 0.1111 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0198 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1924 | 0.1761 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0638 | 0.0608 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0.0638 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3073 | 0.4133 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1286 | 0.173 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.0533 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3073 | 0.2934 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.7436 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.1861 | 0.2298 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.0638 | 0.0608 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1924 | 0.1761 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.1861 | 0.1697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3073 | 0.2934 |
Echinococcus granulosus | flap endonuclease 1 | 0.0026 | 0.0638 | 0.0449 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0198 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0583 | 0.0533 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0074 | 0.3857 | 0.3733 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3073 | 0.3973 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.7436 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0992 | 0.1097 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.1861 | 0.1697 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1286 | 0.1111 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.1861 | 0.2298 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0026 | 0.0638 | 0.0608 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0026 | 0.0638 | 0.0858 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0128 | 0.7436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1861 | 0.2298 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1286 | 0.1111 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0198 | 0.5 |
Entamoeba histolytica | Flap nuclease, putative | 0.0026 | 0.0638 | 0.0608 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3073 | 0.2934 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1924 | 0.1761 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0583 | 0.0533 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0198 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1924 | 0.2587 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1286 | 0.1504 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3073 | 0.4133 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.1861 | 0.1697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3073 | 0.2934 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3073 | 0.2934 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0026 | 0.0638 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3073 | 0.2934 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0026 | 0.0638 | 0.1335 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0.0638 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0583 | 0.0784 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0474 | 0.0282 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0026 | 0.0638 | 0.0449 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1286 | 0.1111 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0128 | 0.7436 | 0.7384 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1286 | 0.1504 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1924 | 0.1761 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0198 | 0.0266 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0128 | 0.7436 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0128 | 0.7436 | 0.7384 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0128 | 0.7436 | 0.7384 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0128 | 0.7436 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0128 | 0.7436 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.0992 | 0.1097 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0583 | 0.0533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3073 | 0.2934 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1924 | 0.1761 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.