Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3318 | 0.3318 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.6339 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.6339 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.545 | 0.8342 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0976 | 0.294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3318 | 0.3318 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3318 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.6339 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3318 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.545 | 0.8342 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1165 | 0.3512 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1165 | 0.3512 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3318 | 0.2596 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0976 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.545 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1165 | 0.3512 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3318 | 0.3318 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1165 | 0.3512 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0976 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.545 | 0.8342 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0976 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0976 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3318 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.6339 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0976 | 0.294 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0976 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3318 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3318 | 0.2596 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3318 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0976 | 0.294 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3318 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.545 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0976 | 0.294 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0976 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3318 | 0.3318 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0976 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.545 | 0.8342 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0976 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3318 | 0.3318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.