Detailed information for compound 1752972

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.543 | Formula: C23H28N2O6S
  • H donors: 1 H acceptors: 4 LogP: 2.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)S(=O)(=O)NC(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(c1)C
  • InChi: 1S/C23H28N2O6S/c1-15-10-16(2)12-17(11-15)13-21(26)25-9-8-23(25,3)22(27)24-32(28,29)18-6-7-19(30-4)20(14-18)31-5/h6-7,10-12,14H,8-9,13H2,1-5H3,(H,24,27)
  • InChiKey: BLIAMPIMLVDEQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis short transient receptor potential channel 6 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium large conductance calcium activated 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential channel 4 0.0184 0.9602 0.9602
Echinococcus granulosus calcium activated potassium channel 0.0184 0.9602 0.9602
Toxoplasma gondii transporter, cation channel family protein 0.0184 0.9602 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0184 0.9602 0.9602
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) voltage-gated calcium channel 0.0184 0.9602 0.9602
Echinococcus granulosus voltage gated hydrogen channel 1 0.0184 0.9602 0.9602
Echinococcus granulosus short transient receptor potential channel 6 0.0191 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0184 0.9602 0.9602
Echinococcus granulosus transient receptor potential cation channel 0.0184 0.9602 0.9602
Echinococcus granulosus voltage dependent calcium channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0184 0.9602 0.9602
Echinococcus granulosus two pore calcium channel protein 2 0.0184 0.9602 0.9602
Brugia malayi hypothetical protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis sodium channel protein 0.0184 0.9602 0.9602
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0184 0.9602 0.9602
Echinococcus granulosus transient receptor potential cation channel 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential gamma protein 0.0184 0.9602 0.9602
Echinococcus multilocularis conserved hypothetical protein 0.0184 0.9602 0.9602
Toxoplasma gondii transporter, cation channel family protein 0.0184 0.9602 1
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium large conductance calcium activated 0.0184 0.9602 0.9602
Toxoplasma gondii transporter, cation channel family protein 0.0184 0.9602 1
Brugia malayi voltage-dependent calcium channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0184 0.9602 0.9602
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3342 0.3342
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage dependent calcium channel 0.0184 0.9602 0.9602
Echinococcus granulosus short transient receptor potential channel 6 0.0184 0.9602 0.9602
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) ion channel NompC 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0184 0.9602 0.9602
Schistosoma mansoni vesicular amine transporter 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0191 1 1
Brugia malayi TAR-binding protein 0.0076 0.3342 0.3342
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3342 0.3342
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0184 0.9602 0.9602
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0184 0.9602 0.5
Brugia malayi ion channel NompC 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Echinococcus granulosus hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3342 0.3342
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus granulosus sodium leak channel non selective protein 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0184 0.9602 0.9602
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0184 0.9602 0.9602
Brugia malayi RNA binding protein 0.0076 0.3342 0.3342
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.9602 0.9602
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0184 0.9602 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis hyperpolarization activated cyclic 0.0184 0.9602 0.9602
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0184 0.9602 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0184 0.9602 0.9602
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0184 0.9602 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Echinococcus granulosus TRP transient receptor potential channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.9602 0.9602
Schistosoma mansoni 60S ribosomal protein L21 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0184 0.9602 1
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.9602 0.9602
Echinococcus multilocularis hyperpolarization activated cyclic 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0184 0.9602 0.9602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3342 0.3342
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0184 0.9602 0.9602
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0184 0.9602 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Echinococcus granulosus two pore calcium channel protein 1 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0184 0.9602 0.9602
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0184 0.9602 0.9602
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0184 0.9602 0.9602
Echinococcus granulosus voltage gated potassium channel 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0184 0.9602 0.9602
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0184 0.9602 0.5
Brugia malayi Cyclic-nucleotide gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential channel 0.0191 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0184 0.9602 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0184 0.9602 0.9602
Echinococcus granulosus hyperpolarization activated cyclic 0.0184 0.9602 0.9602
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0184 0.9602 0.9602
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis shaker cognate 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0184 0.9602 0.9602
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0184 0.9602 0.9602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3342 0.3342
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel protein 0.0184 0.9602 0.9602
Echinococcus multilocularis transient receptor potential cation channel 0.0191 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0184 0.9602 0.9602
Echinococcus granulosus ryanodine receptor 44f 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0184 0.9602 0.9602
Echinococcus multilocularis two pore calcium channel protein 1 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0184 0.9602 0.9602
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0184 0.9602 0.9602
Leishmania major hypothetical protein, conserved 0.0184 0.9602 1
Echinococcus granulosus potassium voltage gated channel protein 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0184 0.9602 0.9602
Loa Loa (eye worm) voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) voltage-dependent calcium channel 0.0184 0.9602 0.9602
Echinococcus granulosus tar DNA binding protein 0.0076 0.3342 0.3342
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0184 0.9602 1
Echinococcus granulosus sodium channel protein 0.0184 0.9602 0.9602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3342 0.3342
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0184 0.9602 0.9602
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential channel 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated ion channel 0.0184 0.9602 0.9602
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0184 0.9602 0.9602
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Brugia malayi cation channel family protein 0.0184 0.9602 0.9602
Echinococcus multilocularis calcium activated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) calcium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3342 0.3342
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus granulosus voltage dependent calcium channel 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel protein 0.0184 0.9602 0.9602
Brugia malayi Transient-receptor-potential like protein 0.0184 0.9602 0.9602
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3342 0.3342
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0184 0.9602 0.9602
Toxoplasma gondii hypothetical protein 0.0184 0.9602 1
Echinococcus granulosus transient receptor potential cation channel 0.0191 1 1
Echinococcus granulosus transient receptor potential gamma protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) voltage-gated potassium channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus multilocularis short transient receptor potential channel 6 0.0191 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-dependent calcium channel 0.0184 0.9602 0.9602
Echinococcus granulosus hyperpolarization activated cyclic 0.0184 0.9602 0.9602
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0184 0.9602 0.9602
Schistosoma mansoni calcium-activated potassium channel 0.0184 0.9602 0.9602
Echinococcus multilocularis ryanodine receptor 44f 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Echinococcus granulosus transient receptor potential cation channel 0.0184 0.9602 0.9602
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0184 0.9602 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0184 0.9602 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0184 0.9602 0.9602
Echinococcus granulosus voltage gated potassium channel 0.0184 0.9602 0.9602
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3342 0.3342
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0184 0.9602 0.9602
Toxoplasma gondii hypothetical protein 0.0184 0.9602 1
Schistosoma mansoni hypothetical protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0191 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602
Loa Loa (eye worm) RNA binding protein 0.0076 0.3342 0.3342
Loa Loa (eye worm) ryanodine receptor 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus granulosus transient receptor potential cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni ryanodine receptor related 0.0184 0.9602 0.9602
Echinococcus multilocularis transfer RNA-Gly 0.0184 0.9602 0.9602
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage gated potassium channel 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0184 0.9602 0.9602
Brugia malayi cation channel family protein 0.0184 0.9602 0.9602
Echinococcus granulosus shaker cognate 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0184 0.9602 0.9602
Echinococcus multilocularis sodium leak channel non selective protein 0.0184 0.9602 0.9602
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0184 0.9602 0.9602
Echinococcus multilocularis potassium voltage gated channel protein 0.0184 0.9602 0.9602
Echinococcus multilocularis two pore calcium channel protein 2 0.0184 0.9602 0.9602
Echinococcus multilocularis voltage dependent calcium channel 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated cation channel 0.0184 0.9602 0.9602
Leishmania major hypothetical protein, unknown function 0.0184 0.9602 1
Schistosoma mansoni transient receptor potential channel 0.0184 0.9602 0.9602
Onchocerca volvulus 0.0184 0.9602 0.5
Loa Loa (eye worm) hypothetical protein 0.0184 0.9602 0.9602
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0184 0.9602 0.9602
Schistosoma mansoni two-pore calcium channel 0.0184 0.9602 0.9602
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0184 0.9602 0.9602
Schistosoma mansoni voltage-gated potassium channel 0.0184 0.9602 0.9602

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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