Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0503 | 0.336 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0085 | 0.0393 | 0.1169 |
Schistosoma mansoni | lamin | 0.0056 | 0.0189 | 0.0563 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0101 | 0.0506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Onchocerca volvulus | 0.0085 | 0.0393 | 0.306 | |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0189 | 0.0563 |
Onchocerca volvulus | 0.0211 | 0.1284 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0503 | 0.336 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0189 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0189 | 0.0563 |
Echinococcus granulosus | acetylcholinesterase | 0.0503 | 0.336 | 0.336 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0503 | 0.336 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0101 | 0.0506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0325 | 0.0967 |
Echinococcus granulosus | acetylcholinesterase | 0.0503 | 0.336 | 0.336 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0325 | 0.0967 |
Brugia malayi | Carboxylesterase family protein | 0.0085 | 0.0393 | 0.1169 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0101 | 0.0506 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0101 | 0.0506 | 1 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0189 | 0.0189 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0101 | 0.0506 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0085 | 0.0393 | 0.1169 |
Onchocerca volvulus | 0.0085 | 0.0393 | 0.306 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0085 | 0.0393 | 0.0393 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0085 | 0.0393 | 0.0393 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0085 | 0.0393 | 0.7764 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0325 | 0.0967 |
Brugia malayi | Carboxylesterase family protein | 0.0085 | 0.0393 | 0.1169 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0101 | 0.0506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0506 | 0.1506 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0172 | 0.0511 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0085 | 0.0393 | 0.7764 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0325 | 0.0967 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0101 | 0.0506 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0503 | 0.336 | 0.336 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0085 | 0.0393 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0312 | 0.0929 |
Brugia malayi | Carboxylesterase family protein | 0.0085 | 0.0393 | 0.1169 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0189 | 0.0563 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0101 | 0.0506 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0296 | 0.5844 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0051 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0182 | 0.0541 |
Echinococcus multilocularis | acetylcholinesterase | 0.0503 | 0.336 | 0.336 |
Brugia malayi | Carboxylesterase family protein | 0.0503 | 0.336 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0503 | 0.336 | 0.336 |
Echinococcus multilocularis | acetylcholinesterase | 0.0503 | 0.336 | 0.336 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0075 | 0.0325 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0085 | 0.0393 | 0.1169 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0312 | 0.0312 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0085 | 0.0393 | 0.0393 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0085 | 0.0393 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.336 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0085 | 0.0393 | 0.1169 |
Brugia malayi | AMP-binding enzyme family protein | 0.0101 | 0.0506 | 0.1506 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0189 | 0.0563 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0085 | 0.0393 | 0.7764 |
Onchocerca volvulus | 0.0101 | 0.0506 | 0.3941 | |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0101 | 0.0506 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0189 | 0.0189 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0189 | 0.0189 |
Onchocerca volvulus | 0.0085 | 0.0393 | 0.306 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0101 | 0.0506 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0101 | 0.0506 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0085 | 0.0393 | 0.1169 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0296 | 0.5844 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0075 | 0.0325 | 0.6421 |
Onchocerca volvulus | 0.0085 | 0.0393 | 0.306 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0296 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.336 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0312 | 0.0929 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0172 | 0.0511 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0312 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0085 | 0.0393 | 1 |
Schistosoma mansoni | gliotactin | 0.0085 | 0.0393 | 0.1169 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0101 | 0.0506 | 1 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0312 | 0.0929 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0085 | 0.0393 | 0.0393 |
Echinococcus granulosus | neuroligin | 0.0085 | 0.0393 | 0.0393 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0312 | 0.0929 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0085 | 0.0393 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0101 | 0.0506 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0312 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0506 | 0.1506 |
Schistosoma mansoni | lamin | 0.0056 | 0.0189 | 0.0563 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0211 | 0.1284 | 0.3822 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0075 | 0.0325 | 0.6421 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0051 | 0.0151 |
Echinococcus granulosus | lamin | 0.0056 | 0.0189 | 0.0189 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0085 | 0.0393 | 0.0393 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0085 | 0.0393 | 0.0393 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0004 | 0.0011 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0101 | 0.0506 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0101 | 0.0506 | 0.1506 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0189 | 0.0563 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0101 | 0.0506 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0101 | 0.0506 | 1 |
Onchocerca volvulus | 0.0056 | 0.0189 | 0.1473 | |
Brugia malayi | Carboxylesterase family protein | 0.0503 | 0.336 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0172 | 0.0511 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0296 | 0.5844 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.003 | 0 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0075 | 0.0325 | 1 |
Onchocerca volvulus | 0.0056 | 0.0189 | 0.1473 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0004 | 0.0011 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0101 | 0.0506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0325 | 0.0967 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Toxoplasma gondii | propionate-CoA ligase | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0393 | 0.1169 |
Onchocerca volvulus | 0.0085 | 0.0393 | 0.306 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0101 | 0.0506 | 0.1506 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0085 | 0.0393 | 0.7764 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.1284 | 0.3822 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0172 | 0.0511 |
Schistosoma mansoni | acetylcholinesterase | 0.0085 | 0.0393 | 0.1169 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0085 | 0.0393 | 0.0393 |
Echinococcus multilocularis | tumor protein p63 | 0.144 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0085 | 0.0393 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0051 | 0.0151 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0101 | 0.0506 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0312 | 0.0929 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0312 | 0.0929 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0312 | 0.0929 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0189 | 0.0189 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0075 | 0.0325 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0312 | 0.0929 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0189 | 0.0189 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0312 | 0.0929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.