Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0405 | 0.2795 | 0.2948 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0405 | 0.2795 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0405 | 0.2795 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0405 | 0.2795 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0405 | 0.2795 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0405 | 0.2795 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0814 | 0.9478 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0405 | 0.2795 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0405 | 0.2795 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0405 | 0.2795 | 0.2795 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0845 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC90 (functional) | = 0.12 uM | Drug dose required to kill 90% of cells(EMT-6 mammary tumor cell line) after 24 hr incubation with a fixed fluence of 2.4 J cm-2. | ChEMBL. | 9599230 |
LC90 (functional) | = 0.25 uM | Drug dose required to kill 90% of cells(EMT-6 mammary tumor cell line) after 1 hr incubation with a fixed fluence of 2.4 J cm-2. | ChEMBL. | 9599230 |
LD90 (functional) | = 0.15 J cm**-2 | Light dose required to kill 90% of cells(EMT-6 mammary tumor cell line) after 24 hr incubation with 1 uM concentration | ChEMBL. | 9599230 |
LD90 (functional) | = 0.4 J cm**-2 | Light dose required to kill 90% of cells(EMT-6 mammary tumor cell line) after 1 hr incubation with 1 uM concentration | ChEMBL. | 9599230 |
Tumor response (functional) | = 12 % | % EMT-6 tumor regression response induced in BALB/c mice after ZnPc and Photofrin-mediated photodynamic therapy (PDT) at a concentration of 1 uM/kg | ChEMBL. | 9599230 |
Tumor response (functional) | = 25 % | % EMT-6 tumor necrosis response induced in BALB/c mice after ZnPc and Photofrin-mediated photodynamic therapy (PDT) at a concentration of 2 umol/kg | ChEMBL. | 9599230 |
Tumor response (functional) | = 25 % | % EMT-6 tumor regression response induced in BALB/c mice after ZnPc and Photofrin-mediated photodynamic therapy (PDT) at a concentration of 2 umol/kg | ChEMBL. | 9599230 |
Tumor response (functional) | = 100 % | % EMT-6 tumor necrosis response induced in BALB/c mice after ZnPc and Photofrin-mediated photodynamic therapy (PDT) at a concentration of 1 uM/kg | ChEMBL. | 9599230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.