Detailed information for compound 1753345

Basic information

Technical information
  • TDR Targets ID: 1753345
  • Name: [2-oxo-2-[(4-piperidin-1-ylphenyl)amino]ethyl ] 2-methoxybenzoate
  • MW: 368.426 | Formula: C21H24N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)OCC(=O)Nc1ccc(cc1)N1CCCCC1
  • InChi: 1S/C21H24N2O4/c1-26-19-8-4-3-7-18(19)21(25)27-15-20(24)22-16-9-11-17(12-10-16)23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-15H2,1H3,(H,22,24)
  • InChiKey: PHLUPYYINFPTJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-2-[[4-(1-piperidyl)phenyl]amino]ethyl] 2-methoxybenzoate
  • 2-methoxybenzoic acid [2-oxo-2-[[4-(1-piperidyl)phenyl]amino]ethyl] ester
  • 2-methoxybenzoic acid [2-keto-2-[(4-piperidinophenyl)amino]ethyl] ester
  • ZINC05710223

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0934 0.3741 0.0006
Onchocerca volvulus 0.1394 0.5805 0.3302
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Echinococcus multilocularis SH2 domain containing protein 7 0.1394 0.5805 0.5805
Brugia malayi Tyrosine-protein kinase PR2 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2327 0.9999 0.9999
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Loa Loa (eye worm) SH2 domain-containing protein 0.1394 0.5805 0.5805
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Schistosoma mansoni protein kinase 0.0934 0.3739 0.0002
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2327 0.9999 0.9999
Brugia malayi bone morphogenetic protein type 1 receptor 0.0933 0.3737 0.3738
Plasmodium vivax tyrosine kinase-like protein, putative 0.0933 0.3737 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2327 0.9999 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1394 0.5805 0.5805
Echinococcus multilocularis epidermal growth factor receptor 0.0933 0.3737 0.3738
Echinococcus granulosus activated cdc42 kinase 1 0.0933 0.3737 0.3735
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0933 0.3737 0.3735
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0933 0.3737 0.3735
Echinococcus granulosus epidermal growth factor receptor 0.0933 0.3737 0.3735
Echinococcus multilocularis tyrosine protein kinase HCK 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/EPH protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni SH2A 0.1394 0.5805 0.3302
Schistosoma mansoni shc transforming protein 0.1394 0.5805 0.3302
Loa Loa (eye worm) TK/Met protein kinase 0.0933 0.3737 0.3738
Giardia lamblia Protein 21.1 0.0933 0.3737 0.5
Echinococcus granulosus tyrosine protein kinase 0.0933 0.3737 0.3735
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase csk 0.0933 0.3737 0.3735
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2327 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus retinal guanylyl cyclase 2 0.0933 0.3737 0.3735
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2327 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0933 0.3737 0.3735
Echinococcus granulosus kinase suppressor of Ras 1 0.0933 0.3737 0.3735
Echinococcus multilocularis 0.1394 0.5805 0.5805
Onchocerca volvulus 0.2327 0.9999 1
Schistosoma mansoni signal transduction protein lnk-related 0.1394 0.5805 0.3302
Echinococcus multilocularis ephrin type A receptor 4 A 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.2327 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.2327 0.9999 1
Echinococcus granulosus SHC transforming protein 3 0.1394 0.5805 0.5803
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase ABL1 0.2327 0.9999 0.9999
Onchocerca volvulus 0.2327 0.9999 1
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase Src64B 0.2327 0.9999 0.9999
Brugia malayi Raf kinase 0.0933 0.3737 0.3738
Schistosoma mansoni suppressor of cytokine signaling 0.1394 0.5805 0.3302
Entamoeba histolytica SH2 domain containing protein 0.1394 0.5805 0.3302
Schistosoma mansoni vav2 0.1394 0.5805 0.3302
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Schistosoma mansoni adapter molecule crk 0.1394 0.5805 0.3302
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0934 0.3739 0.3739
Echinococcus multilocularis insulin receptor 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase Blk 0.2327 0.9999 0.9999
Echinococcus granulosus retinal guanylyl cyclase 2 0.0933 0.3737 0.3735
Loa Loa (eye worm) RGC/RGC protein kinase 0.0933 0.3737 0.3738
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0934 0.3738 0.0001
Trypanosoma brucei protein kinase, putative 0.0934 0.3739 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0933 0.3737 0.3738
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0933 0.3737 0.3738
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1394 0.5805 0.3302
Echinococcus multilocularis receptor type guanylyl cyclase 0.0933 0.3737 0.3738
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0934 0.3739 0.3737
Echinococcus granulosus c src tyrosine kinase 0.2327 0.9999 0.9999
Schistosoma mansoni GTPase activating protein 0.1394 0.5805 0.3302
Echinococcus granulosus tensin 0.1394 0.5805 0.5803
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2327 0.9999 0.9999
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Schistosoma mansoni nck2/grb4 0.1394 0.5805 0.3302
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2327 0.9999 1
Brugia malayi Receptor family ligand binding region containing protein 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK protein kinase 0.2327 0.9999 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0933 0.3737 0.3738
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase csk 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Brugia malayi Variant SH3 domain containing protein 0.1394 0.5805 0.5805
Giardia lamblia Kinase, NEK 0.0933 0.3737 0.5
Brugia malayi RhoGAP domain containing protein 0.1394 0.5805 0.5805
Echinococcus granulosus SH2 motif 0.1394 0.5805 0.5803
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1394 0.5805 0.5803
Trichomonas vaginalis TKL family protein kinase 0.0934 0.3741 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0933 0.3737 0.3735
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0933 0.3737 0.3738
Schistosoma mansoni tensin-related 0.1394 0.5805 0.3302
Brugia malayi Immunoglobulin I-set domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1394 0.5805 0.5805
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi Variant SH3 domain containing protein 0.1394 0.5805 0.5805
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0933 0.3737 0.3735
Echinococcus multilocularis protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/EGFR protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0933 0.3737 0.3738
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1394 0.5805 0.3302
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0933 0.3737 0.3738
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Echinococcus granulosus SH2 domain containing adapter protein F 0.1394 0.5805 0.5803
Echinococcus multilocularis tensin 0.1394 0.5805 0.5805
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0933 0.3737 0.3735
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1394 0.5805 0.5805
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2327 0.9999 1
Loa Loa (eye worm) STAT protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) TK/ROR protein kinase 0.0933 0.3737 0.3738
Plasmodium vivax protein kinase, putative 0.0933 0.3737 0.5
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi Immunoglobulin I-set domain containing protein 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.2327 0.9999 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0933 0.3737 0.3735
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Brugia malayi STAT protein, DNA binding domain containing protein 0.1394 0.5805 0.5805
Schistosoma mansoni hypothetical protein 0.1394 0.5805 0.3302
Entamoeba histolytica protein kinase, putative 0.1394 0.5806 0.3304
Brugia malayi hypothetical protein 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.2327 0.9999 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0933 0.3737 0.3735
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0933 0.3737 0.3738
Echinococcus granulosus ephrin type A receptor 4 A 0.0933 0.3737 0.3735
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1394 0.5805 0.5805
Giardia lamblia Kinase 0.0933 0.3737 0.5
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0934 0.3739 1
Brugia malayi Furin-like cysteine rich region family protein 0.0933 0.3737 0.3738
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1394 0.5805 0.5805
Echinococcus multilocularis protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase shark 0.2327 0.9999 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1394 0.5805 0.3302
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0933 0.3737 0.3735
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Onchocerca volvulus 0.2327 0.9999 1
Onchocerca volvulus 0.2327 0.9999 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.1394 0.5805 0.5805
Brugia malayi tRNA modification GTPase TrmE family protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/DDR protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) RGC/RGC protein kinase 0.0933 0.3737 0.3738
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Echinococcus multilocularis kinase suppressor of Ras 1 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0933 0.3737 0.3738
Echinococcus multilocularis SH2 motif 0.1394 0.5805 0.5805
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0934 0.3739 1
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Brugia malayi Tensin 0.1394 0.5805 0.5805
Echinococcus granulosus natriuretic peptide receptor 1 0.0933 0.3737 0.3735
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1394 0.5805 0.5805
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1394 0.5805 0.5803
Schistosoma mansoni growth factor receptor-bound protein 0.1394 0.5805 0.3302
Echinococcus granulosus fibroblast growth factor receptor 4 0.0933 0.3737 0.3735
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis tensin 0.1394 0.5805 0.5805
Echinococcus granulosus tyrosine protein kinase Fyn 0.2327 0.9999 0.9999
Echinococcus granulosus retinal guanylyl cyclase 2 0.0933 0.3737 0.3735
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1394 0.5805 0.5803
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni tensin 0.1394 0.5805 0.3302
Schistosoma mansoni tensin 0.1394 0.5805 0.3302
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Brugia malayi Tyrosine-protein kinase abl-1 0.2327 0.9999 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0933 0.3737 0.3735
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0934 0.3739 1
Echinococcus granulosus protein tyrosine kinase 0.0933 0.3737 0.3735
Echinococcus multilocularis tyrosine protein kinase csk 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Echinococcus multilocularis protein tyrosine kinase 0.0933 0.3737 0.3738
Echinococcus granulosus expressed conserved protein 0.1394 0.5805 0.5803
Brugia malayi C-terminal src kinase protein 1 0.0933 0.3737 0.3738
Echinococcus multilocularis SH2 motif 0.1394 0.5805 0.5805
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus SH2 domain containing protein 7 0.1394 0.5805 0.5803
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1394 0.5805 0.5805
Echinococcus granulosus protein kinase 0.0933 0.3737 0.3735
Entamoeba histolytica hypothetical protein 0.0934 0.3738 0.0001
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1394 0.5805 0.5805
Echinococcus multilocularis NCK adaptor protein 0.1394 0.5805 0.5805
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus receptor type guanylyl cyclase 0.0933 0.3737 0.3735
Brugia malayi SRC-1 0.2327 0.9999 1
Brugia malayi protein-tyrosine kinase 0.2327 0.9999 1
Echinococcus multilocularis tyrosine kinase 0.0933 0.3737 0.3738
Echinococcus multilocularis epidermal growth factor receptor 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2327 0.9999 1
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni protein kinase 0.0934 0.3739 0.0002
Schistosoma mansoni tyrosine kinase 0.2327 0.9999 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1394 0.5805 0.3302
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase Blk 0.2327 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi Variant SH3 domain containing protein 0.1394 0.5805 0.5805
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1394 0.5805 0.5803
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1394 0.5805 0.5805
Plasmodium vivax tyrosine kinase-like protein, putative 0.0933 0.3737 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1394 0.5805 0.5803
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0933 0.3737 0.3738
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Schistosoma mansoni growth factor receptor-bound protein 0.1394 0.5805 0.3302
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/ACK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FAK protein kinase 0.0933 0.3737 0.3738
Entamoeba histolytica hypothetical protein 0.0934 0.3738 0.0001
Echinococcus multilocularis FL cytokine receptor 0.0933 0.3737 0.3738
Onchocerca volvulus 0.1394 0.5805 0.3302
Echinococcus multilocularis raf serine:threonine protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1394 0.5805 0.5805
Loa Loa (eye worm) RGC/RGC protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi cytokine inducible SH2-containing protein 5 0.1394 0.5805 0.5805
Loa Loa (eye worm) TK/RYK protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1394 0.5805 0.3302
Onchocerca volvulus 0.1394 0.5805 0.3302
Entamoeba histolytica protein kinase domain containing protein 0.0934 0.3739 0.0002
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1394 0.5806 0.3304
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2327 0.9999 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2327 0.9999 1
Echinococcus granulosus growth factor receptor bound protein 2 0.1394 0.5805 0.5803
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/INSR protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Onchocerca volvulus 0.1394 0.5805 0.3302
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Loa Loa (eye worm) SRC-1 0.2327 0.9999 1
Echinococcus multilocularis SHC transforming protein 3 0.1394 0.5805 0.5805
Echinococcus granulosus epidermal growth factor receptor 0.0933 0.3737 0.3735
Echinococcus granulosus SH2 motif 0.1394 0.5805 0.5803
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Brugia malayi Sex muscle abnormal protein 5 0.1394 0.5805 0.5805
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0933 0.3737 0.3735
Echinococcus multilocularis integrin linked protein kinase 0.0933 0.3737 0.3738
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Echinococcus multilocularis activin receptor type 0.0934 0.3739 0.3739
Brugia malayi SH2 domain containing protein 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni tensin 0.1394 0.5805 0.3302
Onchocerca volvulus 0.1394 0.5805 0.3302
Loa Loa (eye worm) protein kinase domain-containing protein 0.0933 0.3737 0.3738
Brugia malayi Guanylyl cyclase protein 23 0.0933 0.3737 0.3738
Brugia malayi Variant SH3 domain containing protein 0.1394 0.5805 0.5805
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0933 0.3737 0.3738
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1394 0.5805 0.3302
Echinococcus granulosus insulin receptor 0.0933 0.3737 0.3735
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1394 0.5805 0.5805
Brugia malayi integrin-linked kinase 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase csk 0.0933 0.3737 0.3735
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Entamoeba histolytica hypothetical protein 0.0934 0.3738 0.0001
Echinococcus granulosus activin receptor type 0.0934 0.3739 0.3737
Echinococcus multilocularis tyrosine protein kinase csk 0.0933 0.3737 0.3738
Echinococcus granulosus suppressor of cytokine signaling 7 0.1394 0.5805 0.5803
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Brugia malayi SH2 domain containing protein 0.1394 0.5805 0.5805
Brugia malayi hypothetical protein 0.2327 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.1394 0.5805 0.5805
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2327 0.9999 1
Echinococcus granulosus tyrosine kinase 0.2327 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2327 0.9999 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1394 0.5805 0.5805
Loa Loa (eye worm) SH2 domain-containing protein 0.1394 0.5805 0.5805
Giardia lamblia Kinase, NEK 0.0933 0.3737 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.2327 0.9999 0.9999
Onchocerca volvulus 0.2327 0.9999 1
Onchocerca volvulus 0.2327 0.9999 1
Schistosoma mansoni hypothetical protein 0.1394 0.5805 0.3302
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2327 0.9999 1
Echinococcus multilocularis N chimaerin 0.1394 0.5805 0.5805
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1394 0.5805 0.5805
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0933 0.3737 0.3735
Echinococcus granulosus tyrosine protein kinase shark 0.2327 0.9999 0.9999
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0933 0.3737 0.3738
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1394 0.5805 0.3302
Echinococcus granulosus activated cdc42 kinase 1 0.0933 0.3737 0.3735
Echinococcus multilocularis signal transduction protein lnk realted 0.1394 0.5805 0.5805
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1394 0.5805 0.5805
Echinococcus multilocularis SH2 motif 0.1394 0.5805 0.5805
Echinococcus granulosus tyrosine protein kinase Srms 0.2327 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase Fyn 0.2327 0.9999 0.9999
Echinococcus granulosus N chimaerin 0.1394 0.5805 0.5803
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0934 0.3739 1
Brugia malayi Protein kinase domain containing protein 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis tyrosine kinase 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus multilocularis heat shock protein 70 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine kinase 0.2327 0.9999 0.9999
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Schistosoma mansoni suppressor of cytokine signaling 0.1394 0.5805 0.3302
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0933 0.3737 0.3738
Brugia malayi hypothetical protein 0.1394 0.5805 0.5805
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0933 0.3737 0.3738
Echinococcus granulosus hypothetical protein 0.1394 0.5805 0.5803
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0933 0.3737 0.3738
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0933 0.3737 0.3735
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/ABL protein kinase 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.2327 0.9999 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0933 0.3737 0.3735
Echinococcus granulosus tyrosine protein kinase csk 0.0933 0.3737 0.3735
Echinococcus multilocularis c src tyrosine kinase 0.2327 0.9999 1
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2327 0.9999 1
Entamoeba histolytica protein kinase, putative 0.0934 0.3738 0.0001
Loa Loa (eye worm) SH2 domain-containing protein 0.1394 0.5805 0.5805
Onchocerca volvulus 0.1394 0.5805 0.3302
Echinococcus granulosus NCK adaptor protein 0.1394 0.5805 0.5803
Schistosoma mansoni tensin-related 0.1394 0.5805 0.3302
Echinococcus granulosus signal transduction protein lnk realted 0.1394 0.5805 0.5803
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase HCK 0.0933 0.3737 0.3735
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2327 0.9999 0.9999
Brugia malayi ephrin receptor 1 precursor 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase Src42A 0.1394 0.5805 0.5803
Schistosoma mansoni protein kinase 0.0934 0.3739 0.0002
Loa Loa (eye worm) TK protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/CSK protein kinase 0.0933 0.3737 0.3738
Echinococcus granulosus suppressor of cytokine signaling 6 0.1394 0.5805 0.5803
Echinococcus multilocularis tyrosine protein kinase pr2 0.0933 0.3737 0.3738
Echinococcus multilocularis transfer RNA-Thr 0.0933 0.3737 0.3738
Loa Loa (eye worm) RGC/RGC protein kinase 0.0933 0.3737 0.3738
Leishmania major protein kinase, putative 0.0934 0.3739 1
Echinococcus multilocularis activated cdc42 kinase 1 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1394 0.5805 0.5805
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine protein kinase Src42A 0.2327 0.9999 0.9999
Echinococcus multilocularis tyrosine protein kinase 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Plasmodium falciparum protein kinase, putative 0.0934 0.3739 1
Brugia malayi SH2 domain containing protein 0.2327 0.9999 1
Echinococcus granulosus integrin linked protein kinase 0.0933 0.3737 0.3735
Loa Loa (eye worm) hypothetical protein 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Echinococcus granulosus tyrosine kinase 0.0933 0.3737 0.3735
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738
Brugia malayi hypothetical protein 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.0933 0.3737 0.3738
Loa Loa (eye worm) TK/FER protein kinase 0.2327 0.9999 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2327 0.9999 1
Brugia malayi Protein kinase domain containing protein 0.0933 0.3737 0.3738

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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