Detailed information for compound 1753544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.539 | Formula: C27H29F3N4O3
  • H donors: 2 H acceptors: 3 LogP: 5.2 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)c1ccc(cc1)c1ccccc1C(F)(F)F)C(C)C
  • InChi: 1S/C27H29F3N4O3/c1-16(2)23(33-26(36)37-3)25(35)34-14-6-9-22(34)24-31-15-21(32-24)18-12-10-17(11-13-18)19-7-4-5-8-20(19)27(28,29)30/h4-5,7-8,10-13,15-16,22-23H,6,9,14H2,1-3H3,(H,31,32)(H,33,36)/t22-,23-/m0/s1
  • InChiKey: LRXRICXCJVCSDK-GOTSBHOMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sulfide quinone reductase 0.0125 0.0577 0.2957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.2066 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0936
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0049 0.0292
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0047
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0577 0.0469
Plasmodium vivax vivapain-2 0.0017 0.0049 0.0537
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0645
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0125 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0168 0.2775
Leishmania major hypothetical protein, conserved 0.0125 0.0577 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.0125 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0208 0.1514
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0049 0.0687
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0125 0.0577 0.0469
Echinococcus multilocularis musashi 0.0027 0.0098 0.0412
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0041
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0125 0.0577 0.261
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0047
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0041
Mycobacterium ulcerans glutaminase 0.027 0.1281 0.0747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0017 0.0049 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0125 0.0577 0.0577
Schistosoma mansoni cpg binding protein 0.0028 0.0107 0.0511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0188 0.1402
Echinococcus multilocularis GPCR, family 2 0.0016 0.0044 0.0166
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0188 0.0826
Mycobacterium tuberculosis Probable reductase 0.0125 0.0577 0.0469
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0158 0.0736 0.3335
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Echinococcus multilocularis geminin 0.0168 0.0782 0.355
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0125 0.0577 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0041
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0168 0.0054
Trypanosoma brucei NADH dehydrogenase 0.0125 0.0577 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0041
Echinococcus granulosus cathepsin l1 0.0011 0.0023 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0125 0.0577 0.7819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0005
Brugia malayi hypothetical protein 0.0234 0.1104 0.8606
Echinococcus granulosus cathepsin l1 0.0017 0.0049 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0768
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0158 0.0736 0.3335
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0047
Giardia lamblia Thioredoxin reductase 0.2066 1 1
Loa Loa (eye worm) fibroinase 0.0017 0.0049 0.0257
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0041
Onchocerca volvulus 0.0011 0.0023 0.0048
Loa Loa (eye worm) cysteine protease 0.0017 0.0049 0.0257
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0125 0.0577 0.0469
Onchocerca volvulus 0.0125 0.0577 0.513
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.0577 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0125 0.0577 0.4462
Trypanosoma brucei hypothetical protein, conserved 0.0125 0.0577 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0125 0.0577 0.0469
Toxoplasma gondii hypothetical protein 0.0041 0.0168 0.2242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0555
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1104 0.5025
Brugia malayi intermediate filament protein 0.0027 0.0098 0.0693
Echinococcus multilocularis thioredoxin glutathione reductase 0.0125 0.0577 0.261
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0125 0.0577 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0971 0.7547
Entamoeba histolytica disulphide oxidoreductase, putative 0.0125 0.0577 0.0568
Echinococcus granulosus geminin 0.0168 0.0782 0.355
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0208 0.1557
Echinococcus granulosus glutamate synthase 0.0125 0.0577 0.261
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0098 0.0645
Toxoplasma gondii NADPH-glutathione reductase 0.0125 0.0577 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0098 0.0645
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0168 0.2775
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0168 0.073
Trypanosoma cruzi NADH dehydrogenase, putative 0.0125 0.0577 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0125 0.0577 0.0577
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0125 0.0577 0.261
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.003 0.0114 0.0484
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0041
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0555
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0114 0.1828
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0115 0.049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0577 0.0469
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0275 0.467
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.011 0.0504 0.0504
Echinococcus granulosus GPCR family 2 0.0016 0.0044 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0049 0.0292
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.011 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0234 0.1104 0.8599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0936
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0257
Echinococcus granulosus dnaJ subfamily B 0.0405 0.1933 0.8824
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0125 0.0577 0.7819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0056
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0125 0.0577 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Plasmodium vivax conserved Plasmodium protein, unknown function 0.008 0.0359 0.4803
Plasmodium vivax SET domain protein, putative 0.003 0.0115 0.1447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Loa Loa (eye worm) glutaminase 0.027 0.1281 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.011 0.0504 0.0504
Echinococcus granulosus cysteine protease 0.0009 0.001 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0047
Plasmodium vivax thioredoxin reductase, putative 0.0125 0.0577 0.7819
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.003 0.0114 0.0816
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0936
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0098
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.003 0.0114 0.1828
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0125 0.0577 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0047
Plasmodium falciparum geranylgeranyltransferase, putative 0.003 0.0114 0.143
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0023 0.0012
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0125 0.0577 0.0469
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0158 0.0736 0.0736
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0047
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.003 0.0114 0.0549
Trypanosoma cruzi lanosterol synthase, putative 0.003 0.0114 0.1828
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0115 0.1248
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Giardia lamblia Glutamate synthase 0.0125 0.0577 0.0469
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0125 0.0577 1
Onchocerca volvulus 0.0017 0.0049 0.0292
Echinococcus granulosus neuropeptide s receptor 0.0457 0.2189 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0107 0.0759
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0168 0.2775
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0168 0.073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Giardia lamblia Prenyltransferase 0.011 0.0504 0.0394
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Echinococcus granulosus lamin 0.0027 0.0098 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0005
Brugia malayi glutaminase DH11.1 0.027 0.1281 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0208 0.1514
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.003 0.0114 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.011 0.0504 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0041
Brugia malayi glutamate synthase 0.0125 0.0577 0.4462
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0125 0.0577 0.261
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0275 0.467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0041
Plasmodium vivax vivapain-2 0.0017 0.0049 0.0537
Echinococcus multilocularis cathepsin L 0.0009 0.001 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0017 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0047
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0188
Schistosoma mansoni sulfide quinone reductase 0.0125 0.0577 0.2957
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0044 0.027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0188 0.0826
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0049 0.0212
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0049 0.0257
Trypanosoma brucei trypanothione reductase 0.0125 0.0577 1
Trichomonas vaginalis glutamate synthase, putative 0.0125 0.0577 0.0577
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0115 0.049
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.0114 0.0114
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0125 0.0577 0.7819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.001 0.001
Schistosoma mansoni lamin 0.0027 0.0098 0.0467
Trichomonas vaginalis disulfide oxidoreductase, putative 0.2066 1 1
Plasmodium falciparum thioredoxin reductase 0.0125 0.0577 0.7819
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0107 0.0711
Leishmania major hypothetical protein, conserved 0.0125 0.0577 1
Leishmania major NADH dehydrogenase, putative 0.0125 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0016 0.0047
Echinococcus granulosus cpg binding protein 0.003 0.0115 0.0487
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0168 0.1193
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0168 0.0828
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0158 0.0736 1
Plasmodium vivax glutathione reductase, putative 0.0125 0.0577 0.7819
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0125 0.0577 0.4434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0158 0.0736 0.5685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0188 0.0826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0577 0.0469
Echinococcus multilocularis cysteine protease 0.0017 0.0049 0.0187
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0115 0.049
Schistosoma mansoni hypothetical protein 0.0034 0.0132 0.0645
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.0168 0.2775
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.0168 0.217
Schistosoma mansoni disulfide oxidoreductase 0.0125 0.0577 0.2957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0577 0.0469
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0158 0.0736 0.0726
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0125 0.0577 1
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.011 0.0504 0.2272
Trichomonas vaginalis disulfide oxidoreductase, putative 0.2066 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.003 0.0114 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Onchocerca volvulus 0.0017 0.0049 0.0292
Toxoplasma gondii hypothetical protein 0.0117 0.0537 0.9231
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0125 0.0577 0.7819
Brugia malayi Pre-SET motif family protein 0.0206 0.0971 0.7559
Echinococcus multilocularis lamin dm0 0.0027 0.0098 0.0412
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0056
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.0168 0.073
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0125 0.0577 1
Echinococcus multilocularis cysteine protease 0.0017 0.0049 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0125 0.0577 0.7819
Leishmania major cathepsin L-like protease 0.0063 0.0275 0.4277
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0044 0.027
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.011 0.0504 0.0504
Schistosoma mansoni glutaminase 0.027 0.1281 0.6615
Plasmodium falciparum glutathione reductase 0.0125 0.0577 0.7819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0125 0.0577 0.0568
Leishmania major cathepsin L-like protease 0.0063 0.0275 0.4277
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0275 0.467
Loa Loa (eye worm) hypothetical protein 0.0158 0.0736 0.5685
Onchocerca volvulus 0.0017 0.0049 0.0292
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0125 0.0577 0.261
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0168 0.2775
Trypanosoma brucei lanosterol synthase 0.003 0.0114 0.1828
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0031 0.0105
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0125 0.0577 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0125 0.0577 1
Echinococcus multilocularis cpg binding protein 0.003 0.0115 0.0487
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0267 0.1342
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0049 0.0187
Onchocerca volvulus 0.0027 0.0098 0.0741
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.003 0.0114 0.0484
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0249 0.4202
Loa Loa (eye worm) hypothetical protein 0.0125 0.0577 0.4434
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.003 0.0114 0.0104
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0049 0.0187
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.011 0.0504 0.8605
Plasmodium falciparum thioredoxin reductase 0.0125 0.0577 0.7819
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0125 0.0577 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.001 0.001
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0125 0.0577 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0098 0.0693
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0125 0.0577 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Echinococcus multilocularis glutamate synthase 0.0125 0.0577 0.261
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0158 0.0736 0.0736
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.0168 0.073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0056
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.011 0.0504 0.3851
Schistosoma mansoni lamin 0.0027 0.0098 0.0467
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1109 0.1109
Echinococcus granulosus protein farnesyltransferase subunit beta 0.011 0.0504 0.2272
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0096
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0049 0.0039
Trichomonas vaginalis glutamate synthase, putative 0.0125 0.0577 0.0577
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0041
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0047
Loa Loa (eye worm) programmed cell death 8 0.0125 0.0577 0.4434
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.2189 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0125 0.0577 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.011 0.0504 0.8701
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0125 0.0577 0.0469
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0158 0.0736 0.3779
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.0577 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0168 0.1238
Treponema pallidum thioredoxin reductase (trxB) 0.2066 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0166
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0125 0.0577 1
Loa Loa (eye worm) thioredoxin reductase 0.0125 0.0577 0.4434
Plasmodium vivax farnesyltransferase beta subunit, putative 0.011 0.0504 0.6803
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0125 0.0577 0.0577
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.0114 0.1225
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0049 0.0537
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0132 0.0961
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0125 0.0577 0.2957
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.003 0.0114 0.1828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0005
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.0307
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0125 0.0577 0.7819
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0056
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0168 0.2775
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0031 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.003 0.0115 0.0552
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0125 0.0577 0.0568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.003 0.0115 0.0552
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0044 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.0114 0.0114
Trichomonas vaginalis glutathione reductase, putative 0.0125 0.0577 0.0577
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0235 0.3524
Schistosoma mansoni glutamate synthase 0.0125 0.0577 0.2957
Onchocerca volvulus 0.0041 0.0168 0.1376
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0168 0.2775
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0125 0.0577 0.0577
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0125 0.0577 1
Giardia lamblia Rab geranylgeranyltransferase 0.0158 0.0736 0.0629
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0049 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis apoptosis inducing factor, putative 0.0125 0.0577 0.0577
Trypanosoma cruzi trypanothione reductase, putative 0.0125 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0041
Trichomonas vaginalis disulfide oxidoreductase, putative 0.2066 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0125 0.0577 1
Onchocerca volvulus 0.0028 0.0107 0.0819
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.001 0.0009
Leishmania major geranylgeranyltransferase, putative 0.003 0.0114 0.1225
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0125 0.0577 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0125 0.0577 0.261
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0125 0.0577 1
Schistosoma mansoni glutamate synthase 0.0125 0.0577 0.2957
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0125 0.0577 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.0168 0.217
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0049 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0125 0.0577 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0023
Loa Loa (eye worm) glutathione reductase 0.0125 0.0577 0.4434
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0166
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.2189 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0125 0.0577 0.0469
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0117 0.0537 0.0537
Entamoeba histolytica thioredoxin reductase, putative 0.2066 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0125 0.0577 1
Schistosoma mansoni hypothetical protein 0.0125 0.0577 0.2957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0005
Trichomonas vaginalis glutaminase, putative 0.027 0.1281 0.1281
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0125 0.0577 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0577 0.0469
Leishmania major trypanothione reductase 0.0125 0.0577 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.2066 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.2066 1 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.011 0.0504 0.3882
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0125 0.0577 0.261
Schistosoma mansoni survival motor neuron protein 0.0048 0.02 0.0998
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0114 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.003 0.0114 0.0114
Onchocerca volvulus 0.0048 0.02 0.1677
Plasmodium falciparum glutathione reductase 0.0125 0.0577 0.7819
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0114 0.143
Onchocerca volvulus 0.003 0.0115 0.0896
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0125 0.0577 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0188 0.0826
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.003 0.0114 0.0104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0208 0.1557
Echinococcus multilocularis lamin 0.0027 0.0098 0.0412
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0125 0.0577 0.261
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0125 0.0577 0.0469
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0038 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0056
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1104 0.5025
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.003 0.0114 0.1225
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0125 0.0577 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0049 0.0257
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0125 0.0577 0.4462
Onchocerca volvulus 0.0017 0.0049 0.0292
Echinococcus granulosus thioredoxin glutathione reductase 0.0125 0.0577 0.261
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0023 0.0098
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0125 0.0577 0.261
Plasmodium falciparum ferrodoxin reductase-like protein 0.0125 0.0577 0.7819
Schistosoma mansoni hypothetical protein 0.0168 0.0782 0.4022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0047
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.0168 0.2242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0125 0.0577 0.7819
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.0168 0.0158
Onchocerca volvulus 0.0235 0.1109 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0041
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0056
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0125 0.0577 0.4462
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0114 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Giardia lamblia NADH oxidase lateral transfer candidate 0.0125 0.0577 0.0469
Loa Loa (eye worm) glutaminase 2 0.027 0.1281 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0041
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.011 0.0504 0.0504
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0275 0.467
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0049 0.0537
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0049 0.0187
Echinococcus granulosus cathepsin L 0.0009 0.001 0.0009
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.003 0.0114 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Onchocerca volvulus 0.0017 0.0049 0.0292
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.1933 0.8824
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0125 0.0577 0.7819
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0626
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0049 0.0187
Toxoplasma gondii selenide, water dikinase 0.0125 0.0577 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0158 0.0736 0.5707
Trichomonas vaginalis disulfide oxidoreductase, putative 0.2066 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0041
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.011 0.0504 0.0494
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0125 0.0577 0.261
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0166
Schistosoma mansoni glutamate synthase 0.0125 0.0577 0.2957
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0577 0.0469
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0017 0.0039
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0125 0.0577 0.0568
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0115 0.0555
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Plasmodium vivax ferrodoxin reductase, putative 0.0125 0.0577 0.7819
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0125 0.0577 0.0568
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0132 0.0915
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0125 0.0577 0.261
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0125 0.0577 0.261
Trichomonas vaginalis mercuric reductase, putative 0.0125 0.0577 0.0577
Plasmodium falciparum protein farnesyltransferase subunit beta 0.011 0.0504 0.6803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0275 0.467
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0115
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.003 0.0114 0.0816
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0577 0.0469
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.003 0.0114 0.0768
Leishmania major farnesyltransferase beta subunit 0.011 0.0504 0.8605
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0023 0.0074
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0049 0.0537
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.2066 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.0049
Toxoplasma gondii thioredoxin reductase 0.0125 0.0577 1
Onchocerca volvulus 0.0017 0.0049 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.022
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0125 0.0577 0.0577
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.02 0.1496
Leishmania major hypothetical protein, conserved 0.0125 0.0577 1
Brugia malayi Thioredoxin reductase 0.0125 0.0577 0.4462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.0049
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0158 0.0736 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0125 0.0577 1
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.2189 1
Brugia malayi cathepsin L-like precursor 0.0011 0.0023 0.0098
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0125 0.0577 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.2066 1 1
Schistosoma mansoni hypothetical protein 0.0405 0.1933 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.011 0.0504 0.8701
Echinococcus granulosus intermediate filament protein 0.0027 0.0098 0.0412
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0038 0.0169
Loa Loa (eye worm) ctsf protein 0.0017 0.0049 0.0257
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0168 0.2775
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0168 0.2775
Echinococcus granulosus lamin dm0 0.0027 0.0098 0.0412
Brugia malayi Pre-SET motif family protein 0.003 0.0115 0.0825
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0049 0.0292
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0125 0.0577 0.261
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0188 0.1358
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0768
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.021 0.3514
Trypanosoma cruzi lanosterol synthase, putative 0.003 0.0114 0.1828
Schistosoma mansoni intermediate filament proteins 0.0027 0.0098 0.0467
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0049 0.0187
Schistosoma mansoni hypothetical protein 0.0168 0.0782 0.4022
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0125 0.0577 0.0568
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0107 0.0452
Onchocerca volvulus 0.0017 0.0049 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0115 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0056
Leishmania major cathepsin L-like protease 0.0063 0.0275 0.4277
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0577 0.0469
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0158 0.0736 0.0736
Schistosoma mansoni hypothetical protein 0.0048 0.02 0.0998
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0049 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0056
Trypanosoma cruzi protein farnesyltransferase, putative 0.011 0.0504 0.8701
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0125 0.0577 0.4462
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0041
Schistosoma mansoni protein farnesyltransferase subunit beta 0.011 0.0504 0.2574
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0125 0.0577 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0125 0.0577 0.261
Plasmodium vivax geranylgeranyltransferase, putative 0.003 0.0114 0.143
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0049 0.0212
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0047
Onchocerca volvulus 0.0027 0.0098 0.0741
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0125 0.0577 0.261
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0005
Brugia malayi glutathione reductase 0.0125 0.0577 0.4462
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0056

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 1 uM Cytotoxicity against human HuH7 cells ChEMBL. 23466233

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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