Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peroxidasin | 0.0185582 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0185582 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0185582 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0185582 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0185582 | 0.5 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0185582 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0185582 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antitrypanosomal activity against Trypanosoma brucei brucei CA427 infected in Swiss Webster mouse assessed as delayed detection of trypanosomes in blood at 10 mg/kg, ip bid after 24 hrs by hemocytometer | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against bloodstream Trypanosoma brucei assessed as DNA profile alteration after 7 hrs by propidium iodide staining-based flow cytometry | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma brucei brucei CA427 infected in Swiss Webster mouse assessed as reduction in replication rate at 10 mg/kg, ip bid measured on day 3 by hemocytometer | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma brucei brucei CA427 infected in Swiss Webster mouse assessed as mouse mortality at 10 mg/kg, po bid by hemocytometer | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against bloodstream Trypanosoma brucei assessed as increase in 1K2N cells after 7 hrs by DAPI staining-based fluorescence microscopy | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against bloodstream Trypanosoma brucei assessed as reduction in 1K1N cells after 7 hrs by DAPI staining-based fluorescence microscopy | ChEMBL. | 23597080 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma brucei brucei CA427 infected in mouse at 40 mg/kg, po qd measured for 3 days by hemocytometer | ChEMBL. | 23597080 | |
Activity (functional) | = 25 % | Antitrypanosomal activity against bloodstream Trypanosoma brucei assessed as increase in 4C equivalents of DNA after 7 hrs by DAPI staining-based fluorescence microscopy (Rvb = 25 %) | ChEMBL. | 23597080 |
Activity (functional) | = 40 % | Reduction of 2C to 4C equivalents of DNA in bloodstream Trypanosoma brucei after 7 hrs by DAPI staining-based fluorescence microscopy (Rvb = 40 %) | ChEMBL. | 23597080 |
EC50 (functional) | = 0.042 uM | Antiparasite activity against Trypanosoma brucei 427 assessed as growth inhibition incubated for 48 hrs by PrestoBlue based fluorescence assay | ChEMBL. | 26087257 |
EC50 (functional) | = 0.042 uM | Antiparasitic activity against Trypanosoma brucei after 48 hrs by cytometry | ChEMBL. | 25685309 |
EC50 (functional) | = 0.042 uM | Antitrypanosomal activity against bloodstream form Trypanosoma brucei brucei Lister 427 after 48 hrs by hemocytometer | ChEMBL. | 23597080 |
EC50 (functional) | = 0.042 uM | Antiparasitic activity against bloodstream Trypanosoma brucei bruei CA427 after 48 hrs by cytometry | ChEMBL. | 25685309 |
EC50 (functional) | = 0.23 uM | Antiparasite activity against Plasmodium falciparum D6 assessed as growth inhibition incubated for 72 hrs by SYBR green fluorescence assay | ChEMBL. | 26087257 |
EC50 (functional) | = 0.23 uM | Antiparasitic activity against Plasmodium falciparum D6 | ChEMBL. | 25685309 |
EC50 (functional) | = 1.8 uM | Antiparasite activity against Trypanosoma cruzi Tulahuen expressing beta-galactosidase assessed as growth inhibition incubated for 96 hrs by CPRG dye based assay | ChEMBL. | 26087257 |
EC50 (functional) | = 1.8 uM | Antiparasitic activity against Trypanosoma cruzi | ChEMBL. | 25685309 |
EC50 (functional) | = 3 uM | Antiparasite activity against Leishmania major promastigotes assessed as growth inhibition incubated for 44 hrs by alamar blue dye based fluorescence assay | ChEMBL. | 26087257 |
EC50 (functional) | = 7.98 uM | Antiparasitic activity against Leishmania major amastigotes | ChEMBL. | 25685309 |
IC50 (ADMET) | > 20 uM | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 23597080 |
PPB (ADMET) | > 99 % | Plasma protein binding in human | ChEMBL. | 25685309 |
PPB (ADMET) | = 99.6 % | Plasma protein binding in BALB/c mouse at 40 mg/kg, po | ChEMBL. | 23597080 |
Survival (functional) | = 9 day | Antitrypanosomal activity against Trypanosoma brucei brucei CA427 infected in Swiss Webster mouse assessed as mouse survival at 10 mg/kg, ip bid by hemocytometer (Rvb = 5 days) | ChEMBL. | 23597080 |
TC50 (ADMET) | > 15 uM | Toxicity against human HepG2 cells incubated for 48 hrs by MTT assay | ChEMBL. | 26087257 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 25685309 | |
Trypanosoma brucei | ChEMBL23 | 25685309 | |
Trypanosoma brucei gambiense | 23597080 | ||
Leishmania major | ChEMBL23 | 25685309 | |
Plasmodium falciparum | 25685309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.