Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0428 | 0.1149 | 0.1149 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Brugia malayi | protein-tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | Protein kinase domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | c src tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | SRC-1 | 0.0428 | 0.1149 | 0.1149 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | acetylcholinesterase | 0.162 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | hypothetical protein | 0.162 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | acetylcholinesterase | 0.162 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | hypothetical protein | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | amidase | 0.1176 | 0.67 | 0.67 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0428 | 0.1149 | 0.1149 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | hypothetical protein | 0.1176 | 0.67 | 0.67 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.162 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.162 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | acetylcholinesterase | 0.162 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | carboxylesterase | 0.162 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | Protein kinase domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | hypothetical protein | 0.162 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1176 | 0.67 | 0.67 |
Schistosoma mansoni | amidase | 0.1176 | 0.67 | 0.67 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0274 | 0 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | Protein kinase domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0428 | 0.1149 | 0.1149 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0274 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1176 | 0.67 | 0.67 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0428 | 0.1149 | 0.1149 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.162 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Loa Loa (eye worm) | SRC-1 | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1176 | 0.67 | 0.67 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.162 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1176 | 0.67 | 0.67 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1176 | 0.67 | 0.67 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0428 | 0.1149 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | Carboxylesterase family protein | 0.162 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.162 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | SH2 domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Brugia malayi | SH2 domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Onchocerca volvulus | 0.0428 | 0.1149 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0428 | 0.1149 | 0.1149 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0428 | 0.1149 | 0.1149 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.1149 | 0.1149 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0428 | 0.1149 | 0.1149 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.