Detailed information for compound 1753798

Basic information

Technical information
  • TDR Targets ID: 1753798
  • Name: N-(4-bromo-2-methylphenyl)-3-[(2-chlorophenyl )methyl]-5-methyl-4-oxothieno[5,4-d]pyrimidin e-6-carboxamide
  • MW: 502.811 | Formula: C22H17BrClN3O2S
  • H donors: 1 H acceptors: 2 LogP: 5.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc(c(c1)C)NC(=O)c1sc2c(c1C)c(=O)n(cn2)Cc1ccccc1Cl
  • InChi: 1S/C22H17BrClN3O2S/c1-12-9-15(23)7-8-17(12)26-20(28)19-13(2)18-21(30-19)25-11-27(22(18)29)10-14-5-3-4-6-16(14)24/h3-9,11H,10H2,1-2H3,(H,26,28)
  • InChiKey: XAGNOSPEFGXKKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-methyl-phenyl)-3-[(2-chlorophenyl)methyl]-5-methyl-4-oxo-thieno[5,4-d]pyrimidine-6-carboxamide
  • N-(4-bromo-2-methylphenyl)-3-[(2-chlorophenyl)methyl]-5-methyl-4-oxo-6-thieno[5,4-d]pyrimidinecarboxamide
  • N-(4-bromo-2-methyl-phenyl)-3-(2-chlorobenzyl)-4-keto-5-methyl-thieno[5,4-d]pyrimidine-6-carboxamide
  • K821-0457
  • NCGC00140927-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni neuropeptide receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.5999 1
Schistosoma mansoni neuropeptide F-like receptor 0.0068 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.5999 0.5999
Brugia malayi Serotonin receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 1 1
Leishmania major cysteine peptidase A (CPA) 0.0052 0.5999 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus granulosus g protein coupled receptor 0.0068 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Brugia malayi Dopamine receptor protein 2 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus multilocularis fmrfamide receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 1 1
Echinococcus multilocularis serotonin receptor 0.0068 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0068 1 1
Schistosoma mansoni neuropeptide receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Onchocerca volvulus 0.0068 1 1
Loa Loa (eye worm) cysteine protease 0.0052 0.5999 0.5055
Brugia malayi putative neuropeptide receptor NPR1 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 1 1
Echinococcus multilocularis g protein coupled receptor 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Echinococcus granulosus sex peptide receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi follicle stimulating hormone receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus hypothetical protein 0.0068 1 1
Schistosoma mansoni amine GPCR 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Brugia malayi neuropeptide F receptor 0.0068 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0068 1 1
Brugia malayi ORL1-like opioid receptor 0.0068 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0068 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 1 1
Echinococcus granulosus cathepsin l1 0.0052 0.5999 0.5999
Onchocerca volvulus 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Echinococcus multilocularis orexin receptor type 2 0.0068 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 1 1
Plasmodium vivax vivapain-2 0.0052 0.5999 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.5999 0.5999
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus multilocularis fmrfamide receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Brugia malayi G-protein coupled receptor 0.0068 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 1 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Echinococcus multilocularis neuropeptide Y receptor 0.0068 1 1
Onchocerca volvulus Cathepsin L homolog 0.0052 0.5999 0.5055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Onchocerca volvulus 0.0068 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) G-protein coupled receptor 0.0068 1 1
Schistosoma mansoni biogenic amine receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Schistosoma mansoni biogenic amine receptor 0.0068 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.5999 1
Schistosoma mansoni hypothetical protein 0.0068 1 1
Brugia malayi neuropeptide F receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus fmrfamide receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Echinococcus multilocularis sex peptide receptor 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.5999 0.5999
Echinococcus granulosus somatostatin receptor 0.0068 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Echinococcus multilocularis cysteine protease 0.0052 0.5999 0.5999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Echinococcus granulosus orexin receptor type 2 0.0068 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.5999 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Loa Loa (eye worm) fibroinase 0.0052 0.5999 0.5055
Onchocerca volvulus 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 1 1
Schistosoma mansoni hypothetical protein 0.0068 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 1 1
Echinococcus granulosus g-protein coupled receptor 0.0068 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 1 1
Entamoeba histolytica cysteine protease, putative 0.0052 0.5999 1
Brugia malayi hypothetical protein 0.0068 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 1 1
Echinococcus multilocularis somatostatin receptor 0.0068 1 1
Schistosoma mansoni opsin-like receptor 0.0068 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.5999 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Echinococcus granulosus serotonin receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi GnHR receptor homolog 0.0068 1 1
Brugia malayi Serotonin receptor 0.0068 1 1
Echinococcus multilocularis serotonin receptor 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 1 1
Schistosoma mansoni biogenic amine receptor 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.1909 0.1909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.5999 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 1 1
Brugia malayi G protein-coupled receptor 0.0068 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.5999 1
Schistosoma mansoni amine GPCR 0.0068 1 1
Onchocerca volvulus Cathepsin L homolog 0.0052 0.5999 0.5055
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus cathepsin l1 0.0035 0.1909 0.1909
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi Dopamine receptor 0.0068 1 1
Schistosoma mansoni myosin xvIII 0.0068 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.5999 0.5999
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.5999 0.5999
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.1909 0.3182
Echinococcus multilocularis cysteine protease 0.0052 0.5999 0.5999
Loa Loa (eye worm) hypothetical protein 0.0052 0.5999 0.5055
Echinococcus granulosus neuropeptide receptor A26 0.0068 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Brugia malayi Dopamine receptor protein 1 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.1909 0.3182
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0068 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.5999 0.5999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Schistosoma mansoni neuropeptide receptor 0.0068 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Schistosoma mansoni adenoreceptor 0.0068 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0068 1 1
Echinococcus granulosus g protein coupled receptor 0.0068 1 1
Echinococcus multilocularis allatostatin A receptor 0.0068 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.5999 0.5999
Echinococcus multilocularis g protein coupled receptor 0.0068 1 1
Plasmodium vivax vivapain-2 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.1909 0.3182
Echinococcus granulosus neuropeptide s receptor 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Brugia malayi larval opioid receptor 0.0068 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni amine GPCR 0.0068 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.1909 0.1909
Brugia malayi putative neuropeptide receptor 0.0068 1 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.1909 0.1909
Brugia malayi RE15519p 0.0068 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0068 1 1
Schistosoma mansoni histamine h1 receptor 0.0068 1 1
Toxoplasma gondii cathepsin CPL 0.0052 0.5999 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.5999 0.5999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 1 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Echinococcus multilocularis neuropeptide receptor 0.0068 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 1 1
Brugia malayi Melatonin receptor type 1A 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.5999 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Brugia malayi hypothetical protein 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0068 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Schistosoma mansoni hypothetical protein 0.0068 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Echinococcus granulosus neuropeptide receptor 0.0068 1 1
Onchocerca volvulus Cathepsin F homolog 0.0052 0.5999 0.5055
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus allatostatin A receptor 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni opsin-like receptor 0.0068 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 1 1
Schistosoma mansoni opsin-like receptor 0.0068 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.5999 0.5055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Echinococcus multilocularis g protein coupled receptor 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Brugia malayi hypothetical protein 0.0068 1 1
Echinococcus multilocularis neuropeptide receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 1 1
Schistosoma mansoni hypothetical protein 0.0068 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.5999 0.5999
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.5999 0.5055
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0068 1 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Echinococcus multilocularis g-protein coupled receptor 0.0068 1 1
Brugia malayi cathepsin L-like precursor 0.0035 0.1909 0.1909
Loa Loa (eye worm) neuropeptide F receptor 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Onchocerca volvulus 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Onchocerca volvulus 0.0068 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 1 1
Schistosoma mansoni neuropeptide receptor 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.5999 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Schistosoma mansoni amine GPCR 0.0068 1 1
Echinococcus granulosus g protein coupled receptor 0.0068 1 1
Brugia malayi AKH receptor 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Echinococcus granulosus neuropeptide receptor 0.0068 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.5999 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0035 0.1909 0.3182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0068 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0068 1 1
Brugia malayi hypothetical protein 0.0068 1 1
Brugia malayi sulfakinin receptor protein 0.0068 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.5999 0.5999
Schistosoma mansoni amine GPCR 0.0068 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 1 1
Loa Loa (eye worm) ctsf protein 0.0052 0.5999 0.5055
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.5999 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.5999 1
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.1909 0.1909
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0068 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.5999 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.5999 1
Onchocerca volvulus 0.0052 0.5999 0.5055
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 1 1
Leishmania major cathepsin L-like protease 0.0052 0.5999 0.5
Onchocerca volvulus 0.0068 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 1 1
Brugia malayi G-protein coupled receptor 0.0068 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0068 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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