Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.861 | 0.8606 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0041 | 0.161 | 0.1584 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.861 | 0.8606 |
Echinococcus multilocularis | serine threonine protein kinase | 0.006 | 0.2969 | 0.7495 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0074 | 0.3952 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0034 | 0.1103 | 0.2736 |
Echinococcus granulosus | protein kinase c iota type | 0.0033 | 0.1012 | 0.2505 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.3952 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0034 | 0.1103 | 0.1076 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.006 | 0.2969 | 0.7495 |
Toxoplasma gondii | AGC kinase | 0.0019 | 0.003 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.003 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.004 | 0.1489 | 0.372 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.003 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.3952 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.004 | 0.1489 | 0.372 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.003 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0019 | 0.003 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0055 | 0.2592 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.004 | 0.1489 | 0.372 |
Onchocerca volvulus | 0.0139 | 0.861 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.003 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0033 | 0.1012 | 0.2505 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0034 | 0.1103 | 0.2736 |
Echinococcus multilocularis | protein kinase c iota type | 0.0033 | 0.1012 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.9593 | 0.9592 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0034 | 0.1103 | 0.2736 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.861 | 0.8606 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0074 | 0.3952 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Brugia malayi | protein kinase C II. | 0.0034 | 0.1103 | 0.4188 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2471 | 0.2449 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1489 | 0.1463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.