TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.646 | Formula: C17H11BrClN3O
H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)[nH]c(=O)c1c2nc(n1C)c1ccccc1Cl
InChi: 1S/C17H11BrClN3O/c1-22-15-14(21-16(22)10-4-2-3-5-12(10)19)11-7-6-9(18)8-13(11)20-17(15)23/h2-8H,1H3,(H,20,23)
InChiKey: RBBQWKNNQXUMHW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin E synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K00799 glutathione S-transferase [EC2.5.1.18], putative	Get druggable targets OG5_131112	All targets in OG5_131112
Schistosoma japonicum	ko:K00799 glutathione S-transferase [EC2.5.1.18], putative	Get druggable targets OG5_131112	All targets in OG5_131112
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	Get druggable targets OG5_131112	All targets in OG5_131112

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Toxoplasma gondii	protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1536	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	ephrin receptor	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/INSR protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	tyrosine kinase	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1536	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0882	0.2591	0.2591
Trypanosoma brucei	Pseudokinase, putative	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0882	0.2591	0.2591
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0882	0.2591	0.2591
Echinococcus multilocularis	FL cytokine receptor	0.0882	0.2591	0.2591
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Brugia malayi	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	c src tyrosine kinase	0.1536	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0882	0.2591	0.2591
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	insulin receptor	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosin kinase, putative	0.0882	0.2591	0.2591
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0882	0.2591	0.5
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.1536	1	1
Echinococcus multilocularis	protein kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.1536	1	1
Trypanosoma brucei	protein kinase, putative	0.0882	0.2591	0.5
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1536	1	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1536	1	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Brugia malayi	hypothetical protein	0.1536	1	1
Echinococcus granulosus	activin receptor type	0.0882	0.2591	0.2591
Brugia malayi	Receptor family ligand binding region containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1536	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0882	0.2591	0.2591
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Onchocerca volvulus		0.1536	1	1
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Entamoeba histolytica	ankyrin repeat protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Plasmodium falciparum	protein kinase, putative	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Leishmania major	protein kinase, putative	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0882	0.2591	0.5
Echinococcus granulosus	insulin receptor	0.0882	0.2591	0.2591
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	epidermal growth factor receptor	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1536	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase shark	0.1536	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Trypanosoma cruzi	protein kinase, putative	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.1536	1	1
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1536	1	1
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1536	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase shark	0.1536	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Brugia malayi	Furin-like cysteine rich region family protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0882	0.2591	0.2591
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	SRC-1	0.1536	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	heat shock protein 70	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0882	0.2591	0.2591
Onchocerca volvulus		0.1536	1	1
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase	0.0882	0.2591	0.2591
Onchocerca volvulus		0.1536	1	1
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Giardia lamblia	Protein 21.1	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1536	1	1
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine kinase	0.1536	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Echinococcus multilocularis	protein tyrosine kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	serine/threonine protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	CAMK family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	serine/threonine RGC	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	protein tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/CSK protein kinase	0.0882	0.2591	0.2591
Brugia malayi	C-terminal src kinase protein 1	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/EPH protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	serine/threonine protein kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	hypothetical protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1536	1	1
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1536	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Toxoplasma gondii	protein kinase domain-containing protein	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	epidermal growth factor receptor	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/DDR protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0882	0.2591	0.2591
Onchocerca volvulus		0.1536	1	1
Entamoeba histolytica	cysteine surface protein, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Srms	0.1536	1	1
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	tyrosine kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.1536	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0882	0.2591	0.2591
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	receptor protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	ankyrin repeat protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	ephrin type A receptor 4 A	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0882	0.2591	0.2591
Schistosoma mansoni	serine/threonine protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1536	1	1
Brugia malayi	SH2 domain containing protein	0.1536	1	1
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0882	0.2591	0.2591
Echinococcus multilocularis	c src tyrosine kinase	0.1536	1	1
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Giardia lamblia	Kinase	0.0882	0.2591	0.5
Brugia malayi	protein-tyrosine kinase	0.1536	1	1
Echinococcus granulosus	tyrosine protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1536	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1536	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	receptor protein kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine kinase	0.1536	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0882	0.2591	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0882	0.2591	0.2591
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1536	1	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0882	0.2591	0.2591
Brugia malayi	ephrin receptor 1 precursor	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1536	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/ROR protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1536	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Onchocerca volvulus		0.1536	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0882	0.2591	0.2591
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	STE family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Onchocerca volvulus		0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Blk	0.1536	1	1
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0882	0.2591	0.2591
Onchocerca volvulus	Tyrosine kinase homolog	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1536	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0882	0.2591	0.2591
Leishmania major	hypothetical protein, conserved	0.0882	0.2591	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.1536	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Brugia malayi	Guanylyl cyclase protein 23	0.0882	0.2591	0.2591
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Giardia lamblia	Kinase, NEK	0.0882	0.2591	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0882	0.2591	0.2591
Echinococcus multilocularis	epidermal growth factor receptor	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	protein tyrosine kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Onchocerca volvulus		0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Leishmania major	protein kinase, putative	0.0882	0.2591	0.5
Onchocerca volvulus		0.1536	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0882	0.2591	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0882	0.2591	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/RYK protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine protein kinase	0.0882	0.2591	0.2591
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0882	0.2591	0.2591
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.2591	0.5
Schistosoma mansoni	ephrin receptor	0.0882	0.2591	0.2591
Trypanosoma cruzi	protein kinase, putative	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Toxoplasma gondii	STE kinase	0.0882	0.2591	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Schistosoma mansoni	tyrosine kinase	0.1536	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1536	1	1
Giardia lamblia	Kinase, NEK	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	activated cdc42 kinase 1	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1536	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	AGC family protein kinase	0.0882	0.2591	0.5
Loa Loa (eye worm)	hypothetical protein	0.0882	0.2591	0.2591
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0882	0.2591	0.2591
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/FAK protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	kinase suppressor of Ras 1	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase pr2	0.0882	0.2591	0.2591
Schistosoma mansoni	serine/threonine protein kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.1536	1	1
Echinococcus multilocularis	activin receptor type	0.0882	0.2591	0.2591
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1536	1	1
Brugia malayi	Raf kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	protein kinase	0.0882	0.2591	0.2591
Plasmodium falciparum	tyrosine kinase-like protein	0.0882	0.2591	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1536	1	1
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1536	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK/Met protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Plasmodium vivax	protein kinase, putative	0.0882	0.2591	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0882	0.2591	0.2591
Brugia malayi	integrin-linked kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Schistosoma mansoni	tyrosine kinase	0.0882	0.2591	0.2591
Brugia malayi	SH2 domain containing protein	0.1536	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0882	0.2591	0.2591
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Onchocerca volvulus		0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1536	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase domain containing protein	0.0882	0.2591	0.2591
Plasmodium falciparum	tyrosine kinase-like protein	0.0882	0.2591	0.5
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Echinococcus granulosus	tyrosine protein kinase csk	0.0882	0.2591	0.2591
Brugia malayi	hypothetical protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Plasmodium falciparum	protein kinase, putative	0.0882	0.2591	0.5
Brugia malayi	SRC-1	0.1536	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1536	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0882	0.2591	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1536	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0882	0.2591	0.2591
Onchocerca volvulus		0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Trichomonas vaginalis	TK family protein kinase	0.0882	0.2591	0.5
Brugia malayi	Protein kinase domain containing protein	0.1536	1	1
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Schistosoma mansoni	protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	protein kinase, putative	0.0882	0.2591	0.2591
Entamoeba histolytica	tyrosine kinase, putative	0.0882	0.2591	0.2591
Trichomonas vaginalis	TKL family protein kinase	0.0882	0.2591	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.1536	1	1
Brugia malayi	Protein kinase domain containing protein	0.0882	0.2591	0.2591
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0882	0.2591	0.2591
Brugia malayi	Tyrosine-protein kinase abl-1	0.1536	1	1
Plasmodium falciparum	protein kinase, putative	0.0882	0.2591	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0882	0.2591	0.2591
Loa Loa (eye worm)	TK protein kinase	0.0882	0.2591	0.2591
Schistosoma mansoni	serine/threonine protein kinase	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein	0.0882	0.2591	0.2591
Entamoeba histolytica	hypothetical protein, conserved	0.0882	0.2591	0.2591
Echinococcus multilocularis	integrin linked protein kinase	0.0882	0.2591	0.2591

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9810 nM	Inhibition of mPGES1 (unknown origin) transfected in HEK293 cells co-expressing COX1 using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 30 mins prior to arachidonic acid addition measured after 60 mins by HTRF assay	ChEMBL.	23394863

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2348046

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1754437