Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0902 | 0.3116 | 0.4504 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1824 | 0.6633 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0902 | 0.3116 | 0.2873 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.173 | 0.6276 | 0.9442 |
Echinococcus granulosus | protein kinase c iota type | 0.0902 | 0.3116 | 0.4504 |
Trichomonas vaginalis | AGC family protein kinase | 0.0902 | 0.3116 | 0.3094 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.175 | 0.635 | 0.9558 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0883 | 0.3042 | 0.3019 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0094 | 0.0032 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.175 | 0.635 | 0.9558 |
Schistosoma mansoni | serine/threonine kinase | 0.0902 | 0.3116 | 0.4698 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0902 | 0.3116 | 0.4504 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Entamoeba histolytica | protein kinase, putative | 0.2632 | 0.9717 | 0.9716 |
Trichomonas vaginalis | AGC family protein kinase | 0.0976 | 0.3399 | 0.3378 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.175 | 0.635 | 0.9571 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0902 | 0.3116 | 0.4504 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0175 | 0.0342 | 0.0342 |
Trichomonas vaginalis | AGC family protein kinase | 0.0902 | 0.3116 | 0.3094 |
Leishmania major | protein kinase, putative | 0.0094 | 0.0032 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Entamoeba histolytica | protein kinase, putative | 0.0902 | 0.3116 | 0.3094 |
Echinococcus granulosus | nervana 2 | 0.173 | 0.6276 | 0.9442 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.2632 | 0.9717 | 0.9717 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.175 | 0.635 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1824 | 0.6633 | 0.6622 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0902 | 0.3116 | 0.4504 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0902 | 0.3116 | 0.2873 |
Trichomonas vaginalis | AGC family protein kinase | 0.0902 | 0.3116 | 0.3094 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0902 | 0.3116 | 0.2873 |
Echinococcus multilocularis | nervana 2 | 0.173 | 0.6276 | 0.9442 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0902 | 0.3116 | 0.4504 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0902 | 0.3116 | 0.2873 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0902 | 0.3116 | 0.2873 |
Leishmania major | protein kinase, putative | 0.0094 | 0.0032 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.2706 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1824 | 0.6633 | 0.6622 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0902 | 0.3116 | 0.4504 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.2632 | 0.9717 | 0.9707 |
Giardia lamblia | Kinase, AGC PKA | 0.175 | 0.635 | 0.5 |
Echinococcus granulosus | NDR protein kinase | 0.0902 | 0.3116 | 0.4504 |
Toxoplasma gondii | AGC kinase | 0.2632 | 0.9717 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.175 | 0.635 | 0.6338 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0215 | 0.0496 | 0.041 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.173 | 0.6276 | 0.9442 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0902 | 0.3116 | 0.4504 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0902 | 0.3116 | 0.4504 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0902 | 0.3116 | 0.4504 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0215 | 0.0496 | 0.041 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1824 | 0.6633 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1824 | 0.6633 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0902 | 0.3116 | 0.3116 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0902 | 0.3116 | 0.4698 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1824 | 0.6633 | 1 |
Brugia malayi | protein kinase C II. | 0.0902 | 0.3116 | 0.3116 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.2706 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0902 | 0.3116 | 0.3116 |
Echinococcus granulosus | protein kinase C gamma type | 0.0902 | 0.3116 | 0.4504 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.173 | 0.6276 | 0.9442 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0902 | 0.3116 | 0.4504 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.173 | 0.6276 | 0.9442 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1824 | 0.6633 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0902 | 0.3116 | 0.3116 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.175 | 0.635 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.175 | 0.635 | 0.9558 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0902 | 0.3116 | 0.4504 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0094 | 0.0032 | 0.5 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0094 | 0.0032 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0199 | 0.0433 | 0.0653 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0902 | 0.3116 | 0.4504 |
Leishmania major | folate/biopterin transporter, putative | 0.0094 | 0.0032 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.173 | 0.6276 | 0.9442 |
Trypanosoma cruzi | Protein kinase B | 0.1824 | 0.6633 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.2706 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.3116 | 0.2873 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0146 | 0.0234 | 0.0352 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.173 | 0.6276 | 0.9442 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0158 | 0.0279 | 0.0279 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0902 | 0.3116 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0496 | 0.016 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0902 | 0.3116 | 0.4504 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0902 | 0.3116 | 0.4504 |
Schistosoma mansoni | atypical protein kinase C | 0.0902 | 0.3116 | 0.4698 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0902 | 0.3116 | 0.2873 |
Echinococcus multilocularis | protein kinase c iota type | 0.0902 | 0.3116 | 0.4504 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.2706 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.