TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.533 | Formula: C25H32N2O4
H donors: 0 H acceptors: 3 LogP: 2.62 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)[C@@]12CCCC=C2N(C(=O)[C@@H](C1)CC(=O)N1CCCC1)Cc1ccccc1
InChi: 1S/C25H32N2O4/c1-2-31-24(30)25-13-7-6-12-21(25)27(18-19-10-4-3-5-11-19)23(29)20(17-25)16-22(28)26-14-8-9-15-26/h3-5,10-12,20H,2,6-9,13-18H2,1H3/t20-,25+/m1/s1
InChiKey: KPNAJVRPHFRICY-NLFFAJNJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0221	0.1738	0.4928
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0129	0.1452
Toxoplasma gondii	PHD-finger domain-containing protein	0.0126	0.0886	1
Echinococcus granulosus	peregrin	0.013	0.0923	0.2508
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0095	0.0611	0.1584
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0221	0.1738	0.4928
Echinococcus granulosus	jumonji domain containing 1A	0.0041	0.0124	0.0138
Echinococcus granulosus	phd:f box containing protein	0.0041	0.0124	0.0138
Plasmodium vivax	hypothetical protein, conserved	0.0126	0.0886	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Toxoplasma gondii	PHD-finger domain-containing protein	0.0041	0.0129	0.1452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	hypothetical protein	0.0221	0.1738	0.4928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	neuropeptides capa receptor	0.0221	0.1738	0.4928
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0041	0.0129	0.1452
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Toxoplasma gondii	PHD-finger domain-containing protein	0.0126	0.0886	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	neuropeptide receptor	0.0221	0.1738	0.6357
Brugia malayi	Serotonin receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0221	0.1738	0.6357
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0221	0.1738	0.4928
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.1738	0.4928
Echinococcus multilocularis	neuropeptide receptor A26	0.0221	0.1738	0.4928
Echinococcus granulosus	somatostatin receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	g protein coupled receptor	0.0221	0.1738	0.4928
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0041	0.0129	0.1452
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0152	0.1123	0.4003
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.1738	0.4928
Schistosoma mansoni	neuropeptide receptor	0.0221	0.1738	0.6357
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0221	0.1738	0.6357
Brugia malayi	Bromodomain containing protein	0.013	0.0923	0.2508
Plasmodium vivax	JmjC domain containing protein	0.0041	0.0124	0.14
Brugia malayi	neuropeptide F receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	neuropeptide Y receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0221	0.1738	0.8231
Echinococcus granulosus	neuropeptide s receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	neuropeptide Y receptor	0.0221	0.1738	0.4928
Brugia malayi	Melatonin receptor type 1A	0.0221	0.1738	0.4928
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Echinococcus granulosus	biogenic amine 5HT receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.0197	0.0354
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0303	0.247	0.247
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0221	0.1738	0.4928
Schistosoma mansoni	opsin-like receptor	0.0221	0.1738	0.6357
Echinococcus granulosus	allatostatin A receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0221	0.1738	0.8231
Brugia malayi	jmjC domain containing protein	0.0412	0.3447	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	biogenic amine receptor	0.0221	0.1738	0.6357
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0303	0.247	0.247
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	jumonji domain containing protein	0.0175	0.1327	0.3708
Onchocerca volvulus		0.0221	0.1738	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	orexin receptor type 2	0.0221	0.1738	0.4928
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0221	0.1738	0.6357
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0412	0.3447	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0221	0.1738	0.4928
Schistosoma mansoni	amine GPCR	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	neuropeptide receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Brugia malayi	Serotonin receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	jumonji domain containing protein	0.0175	0.1327	0.3708
Echinococcus granulosus	dro:myosuppressin receptor	0.0221	0.1738	0.4928
Onchocerca volvulus		0.0221	0.1738	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.062	0.5307	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Schistosoma mansoni	biogenic amine receptor	0.0221	0.1738	0.6357
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0041	0.0124	0.0138
Schistosoma mansoni	myosin xvIII	0.0221	0.1738	0.6357
Echinococcus granulosus	7TM GPCR rhodopsin	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	biogenic amine 5HT receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	g-protein coupled receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	fmrfamide receptor	0.0221	0.1738	0.4928
Brugia malayi	neuropeptide F receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	hypothetical protein	0.0041	0.0129	0.0196
Schistosoma mansoni	hypothetical protein	0.0221	0.1738	0.6357
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0221	0.1738	0.4928
Brugia malayi	ORL1-like opioid receptor	0.0221	0.1738	0.4928
Mycobacterium ulcerans	3-dehydroquinate dehydratase	0.1145	1	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.016	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	jumonji domain containing protein	0.0041	0.0124	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Brugia malayi	G protein-coupled receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	neuropeptide F receptor	0.0221	0.1738	0.8231
Brugia malayi	jmjC domain containing protein	0.0041	0.0124	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0221	0.1738	0.4928
Onchocerca volvulus		0.0221	0.1738	1
Loa Loa (eye worm)	PHD-finger family protein	0.0126	0.0886	0.3888
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0221	0.1738	0.4928
Schistosoma mansoni	neuropeptide receptor	0.0221	0.1738	0.6357
Echinococcus multilocularis	peregrin	0.013	0.0923	0.2508
Echinococcus granulosus	g-protein coupled receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	dro:myosuppressin receptor	0.0221	0.1738	0.4928
Onchocerca volvulus	Alhambra homolog	0.0126	0.0886	0.2441
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0126	0.0886	0.3096
Brugia malayi	PHD-finger family protein	0.0126	0.0886	0.24
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus multilocularis	neuropeptide s receptor	0.0221	0.1738	0.4928
Brugia malayi	putative neuropeptide receptor NPR1	0.0221	0.1738	0.4928
Schistosoma mansoni	biogenic amine receptor	0.0221	0.1738	0.6357
Echinococcus granulosus	neuropeptide receptor	0.0221	0.1738	0.4928
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0221	0.1738	0.4928
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Schistosoma mansoni	opsin-like receptor	0.0221	0.1738	0.6357
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	0.0146
Echinococcus multilocularis	JmjC domain containing protein 4	0.0041	0.0124	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0886	0.3888
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	neuropeptide Y receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0126	0.0886	0.24
Schistosoma mansoni	neuropeptide F-like receptor	0.0221	0.1738	0.6357
Brugia malayi	GnHR receptor homolog	0.0221	0.1738	0.4928
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0221	0.1738	0.4928
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	0.0146
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	acetyltransferase	0.0166	0.1243	0.5709
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0166	0.1243	0.346
Echinococcus granulosus	sex peptide receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	hypothetical protein	0.0221	0.1738	0.6357
Schistosoma mansoni	adenoreceptor	0.0221	0.1738	0.6357
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0095	0.0611	0.1584
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0221	0.1738	0.6357
Echinococcus multilocularis	G protein coupled receptor 139	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0041	0.0124	0.14
Brugia malayi	AKH receptor	0.0221	0.1738	0.4928
Brugia malayi	acetyltransferase, GNAT family protein	0.0166	0.1243	0.346
Echinococcus granulosus	neuropeptide receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	serotonin receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	lysine specific demethylase 5A	0.0152	0.1123	0.3103
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0303	0.247	0.247
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.1738	0.4928
Brugia malayi	G-protein coupled receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	orexin receptor type 2	0.0221	0.1738	0.4928
Echinococcus granulosus	neuropeptides capa receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	phosphatidylserine receptor	0.0041	0.0124	0.0178
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0041	0.0124	0.14
Echinococcus multilocularis	lysine specific demethylase 6a	0.0041	0.0124	0.0138
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0221	0.1738	0.4928
Loa Loa (eye worm)	neuropeptide F receptor	0.0221	0.1738	0.8231
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus granulosus	L aminoadipate semialdehyde	0.0095	0.0611	0.1584
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0221	0.1738	0.8231
Echinococcus granulosus	G protein coupled receptor 139	0.0221	0.1738	0.4928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0221	0.1738	0.6357
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.1738	0.6357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Brugia malayi	AF-10 protein	0.0041	0.0129	0.0152
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0221	0.1738	0.4928
Brugia malayi	jmjC domain containing protein	0.0041	0.0124	0.0138
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0221	0.1738	0.4928
Echinococcus granulosus	serotonin receptor	0.0221	0.1738	0.4928
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Brugia malayi	Dopamine receptor protein 1	0.0221	0.1738	0.4928
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.016	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	neuropeptide FF receptor 2	0.0221	0.1738	0.4928
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0221	0.1738	0.4928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Onchocerca volvulus		0.0221	0.1738	1
Schistosoma mansoni	hypothetical protein	0.0221	0.1738	0.6357
Schistosoma mansoni	protein phosphatase 2C	0.0041	0.0124	0.0178
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	fmrfamide receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	amine GPCR	0.0221	0.1738	0.6357
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.1738	0.4928
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0412	0.3447	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0041	0.0124	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Loa Loa (eye worm)	melatonin receptor type 1A	0.0221	0.1738	0.8231
Brugia malayi	jmjC domain containing protein	0.0041	0.0124	0.0138
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0221	0.1738	0.4928
Brugia malayi	sulfakinin receptor protein	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0095	0.0611	0.2043
Echinococcus granulosus	7tm_1 domain containing protein	0.0221	0.1738	0.4928
Schistosoma mansoni	amine GPCR	0.0221	0.1738	0.6357
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0041	0.0129	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0221	0.1738	0.6357
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	jumonji domain containing protein	0.0328	0.269	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.0197	0.222
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0	0.5
Schistosoma mansoni	hypothetical protein	0.0221	0.1738	0.6357
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0221	0.1738	0.4928
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0041	0.0129	0.0196
Onchocerca volvulus		0.0221	0.1738	1
Treponema pallidum	fructose-bisphosphate aldolase	0.062	0.5307	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0221	0.1738	0.6357
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.0197	0.222
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Giardia lamblia	Fructose-bisphosphate aldolase	0.062	0.5307	1
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Brugia malayi	jmjC domain containing protein	0.0041	0.0124	0.0138
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus granulosus	lysine specific demethylase 6a	0.0041	0.0124	0.0138
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Schistosoma mansoni	amine GPCR	0.0221	0.1738	0.6357
Plasmodium falciparum	phd finger protein, putative	0.0126	0.0886	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0152	0.1123	0.3103
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0221	0.1738	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0221	0.1738	0.6357
Brugia malayi	follicle stimulating hormone receptor	0.0221	0.1738	0.4928
Echinococcus multilocularis	somatostatin receptor	0.0221	0.1738	0.4928
Brugia malayi	Dopamine receptor	0.0221	0.1738	0.4928
Brugia malayi	RE15519p	0.0221	0.1738	0.4928
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0221	0.1738	0.4928
Mycobacterium tuberculosis	3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase)	0.1145	1	1
Onchocerca volvulus		0.0221	0.1738	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	amine GPCR	0.0221	0.1738	0.6357
Loa Loa (eye worm)	jmjC domain-containing protein	0.026	0.2085	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0041	0.0124	0.14
Echinococcus multilocularis	phd:f box containing protein	0.0041	0.0124	0.0138
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0221	0.1738	0.4928
Loa Loa (eye worm)	G-protein coupled receptor	0.0221	0.1738	0.8231
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0221	0.1738	0.8231
Loa Loa (eye worm)	TYRA-2 protein	0.0221	0.1738	0.8231
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0221	0.1738	0.4928
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0	0.5
Schistosoma mansoni	hypothetical protein	0.0126	0.0886	0.3096
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0611	0.2485
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0221	0.1738	0.6357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Echinococcus multilocularis	jumonji domain containing 1A	0.0041	0.0124	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0152	0.1123	0.4003
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.062	0.5307	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0221	0.1738	0.6357
Brugia malayi	G protein-coupled receptor F59B2.13	0.0221	0.1738	0.4928
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.0197	0.222
Echinococcus granulosus	tm gpcr rhodopsin	0.0221	0.1738	0.4928
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0041	0.0124	0.0138
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	0.0146
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0221	0.1738	1
Onchocerca volvulus		0.0221	0.1738	1
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus multilocularis	sex peptide receptor	0.0221	0.1738	0.4928
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Loa Loa (eye worm)	jmjC domain-containing protein	0.0152	0.1123	0.5095
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0221	0.1738	0.6357
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0221	0.1738	0.6357
Schistosoma mansoni	opsin-like receptor	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Giardia lamblia	PHD finger protein 15	0.0126	0.0886	0.141
Schistosoma mansoni	neuropeptide receptor	0.0221	0.1738	0.6357
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Echinococcus multilocularis	neuropeptide receptor	0.0221	0.1738	0.4928
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0041	0.0129	1
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0216	0.169	0.7989
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0221	0.1738	0.6357
Brugia malayi	jmjC domain containing protein	0.0152	0.1123	0.3103
Schistosoma mansoni	phd/f-box containing protein	0.0041	0.0124	0.0178
Loa Loa (eye worm)	G-protein coupled receptor	0.0221	0.1738	0.8231
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0221	0.1738	0.8231
Onchocerca volvulus		0.0221	0.1738	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0166	0.1243	0.4464
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0129	0.0023
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.0409	0.0984
Brugia malayi	putative neuropeptide receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	g protein coupled receptor	0.0221	0.1738	0.4928
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0221	0.1738	0.6357
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0161	0.1202	0.3337
Echinococcus granulosus	PHD finger protein rhinoceros	0.0126	0.0886	0.24
Brugia malayi	larval opioid receptor	0.0221	0.1738	0.4928
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.062	0.5307	1
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.1738	0.4928
Brugia malayi	Dopamine receptor protein 2	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Echinococcus multilocularis	allatostatin A receptor	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	growth hormone secretagogue receptor	0.0221	0.1738	0.6357
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	g protein coupled receptor	0.0221	0.1738	0.4928
Brugia malayi	PHD-finger family protein	0.0041	0.0129	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0041	0.0124	0.9644
Brugia malayi	G-protein coupled receptor	0.0221	0.1738	0.4928
Onchocerca volvulus		0.0221	0.1738	1
Echinococcus granulosus	JmjC domain containing protein 4	0.0041	0.0124	0.0138
Echinococcus granulosus	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Echinococcus granulosus	g protein coupled receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0221	0.1738	0.4928
Brugia malayi	hypothetical protein	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0041	0.0124	0.0178
Echinococcus multilocularis	serotonin receptor	0.0221	0.1738	0.4928
Onchocerca volvulus		0.0221	0.1738	1
Leishmania major	hypothetical protein, conserved	0.0041	0.0124	1
Schistosoma mansoni	histamine h1 receptor	0.0221	0.1738	0.6357
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.0409	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Echinococcus multilocularis	fmrfamide receptor	0.0221	0.1738	0.4928
Echinococcus granulosus	neuropeptide receptor A26	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0221	0.1738	0.4928
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1738	0.8231
Onchocerca volvulus		0.0221	0.1738	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0221	0.1738	0.6357
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0041	0.0124	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0041	0.0129	0.0152

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2356119

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1754770