TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 423.53 | Formula: C17H17N3O4S3
H donors: 3 H acceptors: 4 LogP: 2.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)Nc1cc(ccc1NS(=O)(=O)c1cccs1)c1csc(=O)[nH]1
InChi: 1S/C17H17N3O4S3/c1-2-4-15(21)18-13-9-11(14-10-26-17(22)19-14)6-7-12(13)20-27(23,24)16-5-3-8-25-16/h3,5-10,20H,2,4H2,1H3,(H,18,21)(H,19,22)
InChiKey: HPBVUAIMXNPJTN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	bromodomain containing 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Toxoplasma gondii	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma japonicum	ko:K08871 bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Schistosoma mansoni	bromodomain-containing protein 3 brd3	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Neospora caninum	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Entamoeba histolytica	bromodomain-containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Giardia lamblia	Kinase, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus granulosus	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Candida albicans	two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1	Get druggable targets OG5_126719	All targets in OG5_126719
Onchocerca volvulus		Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Echinococcus multilocularis	bromodomain containing 2	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Loa Loa (eye worm)	bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_126719	All targets in OG5_126719
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_126719	All targets in OG5_126719
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_126719	All targets in OG5_126719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0174	0.3169	0.5
Brugia malayi	SH2 domain containing protein	0.0447	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0447	1	1
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0447	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/RYK protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/CSK protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	SH2 domain containing protein 7	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0447	1	1
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	SH2 motif	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	nck2/grb4	0.0273	0.5637	0.5175
Loa Loa (eye worm)	serine/threonine protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0273	0.5637	0.5175
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0174	0.3169	0.2445
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Schistosoma mansoni	suppressor of cytokine signaling	0.0273	0.5637	0.5175
Brugia malayi	Variant SH3 domain containing protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0273	0.5637	0.3613
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0273	0.5637	0.3613
Echinococcus granulosus	raf serine:threonine protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	activin receptor type	0.0174	0.3169	0.2445
Loa Loa (eye worm)	SH2 domain-containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0273	0.5637	0.5175
Echinococcus multilocularis	SHC transforming protein 3	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Plasmodium falciparum	protein kinase, putative	0.0174	0.3169	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	tensin	0.0273	0.5637	0.5175
Echinococcus multilocularis	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0143	0.0451
Echinococcus granulosus	activated cdc42 kinase 1	0.0174	0.3169	0.2445
Loa Loa (eye worm)	SH2 domain-containing protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	c src tyrosine kinase	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Giardia lamblia	Kinase, NEK	0.0174	0.3169	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Onchocerca volvulus		0.0273	0.5637	0.3613
Onchocerca volvulus		0.0447	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0447	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0273	0.5637	0.3613
Echinococcus granulosus	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	N chimaerin	0.0273	0.5637	0.5175
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0174	0.3169	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0174	0.3169	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0447	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0174	0.3169	0.2445
Echinococcus granulosus	protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0273	0.5637	0.3613
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0447	1	1
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0273	0.5637	0.5175
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0447	1	1
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Toxoplasma gondii	STE kinase	0.0174	0.3169	0.5
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0174	0.3169	0.2445
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	epidermal growth factor receptor	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0447	1	1
Onchocerca volvulus		0.0447	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0447	1	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	integrin linked protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Variant SH3 domain containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	ephrin type A receptor 4 A	0.0174	0.3169	0.2445
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine kinase	0.0447	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TK family protein kinase	0.0174	0.3169	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0273	0.5637	0.5175
Trichomonas vaginalis	AGC family protein kinase	0.0174	0.3169	1
Brugia malayi	Guanylyl cyclase protein 23	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0273	0.5637	0.5175
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	protein tyrosine kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	ephrin receptor	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine kinase	0.0447	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0447	1	1
Brugia malayi	Protein kinase domain containing protein	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0174	0.3169	0.2445
Brugia malayi	hypothetical protein	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tensin	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0447	1	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/ACK protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	receptor type guanylyl cyclase	0.0174	0.3169	0.2445
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine kinase	0.0447	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0447	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0174	0.3169	0.2445
Giardia lamblia	Kinase	0.0174	0.3169	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0447	1	1
Echinococcus granulosus	insulin receptor	0.0174	0.3169	0.2445
Schistosoma mansoni	growth factor receptor-bound protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/Met protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	activated cdc42 kinase 1	0.0174	0.3169	0.2445
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0143	0.0451
Echinococcus granulosus	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Echinococcus granulosus	activated cdc42 kinase 1	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0174	0.3169	0.2445
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0174	0.3169	1
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Plasmodium falciparum	tyrosine kinase-like protein	0.0174	0.3169	0.5
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	Variant SH3 domain containing protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	tensin	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	Furin-like cysteine rich region family protein	0.0174	0.3169	0.2445
Echinococcus granulosus	c src tyrosine kinase	0.0447	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0174	0.3169	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Brugia malayi	hypothetical protein	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0447	1	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0174	0.3169	0.2445
Trypanosoma cruzi	protein kinase, putative	0.0174	0.3169	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0447	1	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0273	0.5637	0.5175
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0273	0.5637	0.5175
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0447	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Onchocerca volvulus		0.0273	0.5637	0.3613
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	integrin linked protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/ABL protein kinase	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0143	0.0451
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	hypothetical protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	SH2 domain containing protein 7	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	SH2 motif	0.0273	0.5637	0.5175
Brugia malayi	Variant SH3 domain containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Blk	0.0447	1	1
Onchocerca volvulus		0.0447	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0273	0.5637	0.5175
Echinococcus multilocularis	tyrosine protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0447	1	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	SRC-1	0.0447	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Schistosoma mansoni	tensin-related	0.0273	0.5637	0.5175
Echinococcus multilocularis	SH2 motif	0.0273	0.5637	0.5175
Loa Loa (eye worm)	STAT protein	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0447	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	hypothetical protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0174	0.3169	0.2445
Echinococcus granulosus	kinase suppressor of Ras 1	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK protein kinase	0.0447	1	1
Echinococcus granulosus	SH2 motif	0.0273	0.5637	0.5175
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0174	0.3169	0.2445
Echinococcus granulosus	signal transduction protein lnk realted	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	expressed conserved protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Plasmodium falciparum	protein kinase, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0447	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0273	0.5637	0.5175
Echinococcus multilocularis		0.0273	0.5637	0.5175
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0447	1	1
Trichomonas vaginalis	STE family protein kinase	0.0174	0.3169	1
Entamoeba histolytica	SH2 domain containing protein	0.0273	0.5637	0.3613
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Trypanosoma brucei	Pseudokinase, putative	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Plasmodium falciparum	protein kinase, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0174	0.3169	0.2445
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0174	0.3169	0.2445
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	suppressor of cytokine signaling	0.0273	0.5637	0.5175
Brugia malayi	ephrin receptor 1 precursor	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	Sex muscle abnormal protein 5	0.0273	0.5637	0.5175
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0174	0.3169	0.2445
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0273	0.5637	0.5175
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	SH2 motif	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0174	0.3169	0.2445
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0273	0.5637	0.5175
Trypanosoma brucei	protein kinase, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Schistosoma mansoni	protein tyrosine kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	epidermal growth factor receptor	0.0174	0.3169	0.2445
Trichomonas vaginalis	CAMK family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0174	0.3169	0.2445
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Schistosoma mansoni	adapter molecule crk	0.0273	0.5637	0.5175
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	SH2A	0.0273	0.5637	0.5175
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0447	1	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0174	0.3169	0.2445
Leishmania major	hypothetical protein, conserved	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	serine/threonine RGC	0.0174	0.3169	0.2445
Toxoplasma gondii	protein kinase domain-containing protein	0.0174	0.3169	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0273	0.5637	0.5175
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0447	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Plasmodium vivax	protein kinase, putative	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tensin	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	protein kinase atn1, putative	0.0174	0.3169	1
Brugia malayi	SH2 domain containing protein	0.0447	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0273	0.5637	0.3613
Brugia malayi	SH2 domain containing protein	0.0273	0.5637	0.5175
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Toxoplasma gondii	protein kinase	0.0174	0.3169	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	SH2 domain-containing protein	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0447	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	tensin	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0447	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0273	0.5637	0.3613
Giardia lamblia	Kinase, NEK	0.0174	0.3169	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0174	0.3169	0.2445
Echinococcus multilocularis	signal transduction protein lnk realted	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0447	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0174	0.3169	0.5
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0447	1	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0174	0.3169	0.2445
Echinococcus multilocularis	epidermal growth factor receptor	0.0174	0.3169	0.2445
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0447	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Schistosoma mansoni	tensin	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/FAK protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	vav2	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Brugia malayi	integrin-linked kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0174	0.3169	0.5
Trichomonas vaginalis	bromodomain containing protein, putative	0.0053	0.0143	0.0451
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	heat shock protein 70	0.0174	0.3169	0.2445
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0273	0.5637	0.5175
Echinococcus granulosus	natriuretic peptide receptor 1	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Onchocerca volvulus		0.0447	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Brugia malayi	RhoGAP domain containing protein	0.0273	0.5637	0.5175
Entamoeba histolytica	protein kinase, putative	0.0273	0.5637	0.3613
Schistosoma mansoni	shc transforming protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	activin receptor type	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0174	0.3169	0.2445
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0273	0.5637	0.3613
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0273	0.5637	0.5175
Brugia malayi	hypothetical protein	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0174	0.3169	0.2445
Brugia malayi	C-terminal src kinase protein 1	0.0174	0.3169	0.2445
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0273	0.5637	0.5175
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0174	0.3169	0.2445
Leishmania major	protein kinase, putative	0.0174	0.3169	0.5
Schistosoma mansoni	hypothetical protein	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	serine/threonine protein kinase	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Echinococcus multilocularis	insulin receptor	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0447	1	1
Brugia malayi	protein-tyrosine kinase	0.0447	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0174	0.3169	0.2445
Schistosoma mansoni	tyrosine kinase	0.0447	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0447	1	1
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Echinococcus granulosus	protein tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0273	0.5637	0.5175
Loa Loa (eye worm)	SRC-1	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Brugia malayi	Raf kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase shark	0.0447	1	1
Schistosoma mansoni	tensin-related	0.0273	0.5637	0.5175
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Leishmania major	protein kinase, putative	0.0174	0.3169	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK/FER protein kinase	0.0447	1	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0273	0.5637	0.5175
Echinococcus granulosus	epidermal growth factor receptor	0.0174	0.3169	0.2445
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0174	0.3169	0.5
Brugia malayi	hypothetical protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0174	0.3169	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0174	0.3169	0.2445
Echinococcus granulosus	SHC transforming protein 3	0.0273	0.5637	0.5175
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0273	0.5637	0.5175
Echinococcus multilocularis	protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Echinococcus granulosus	hypothetical protein	0.0273	0.5637	0.5175
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0174	0.3169	0.2445
Schistosoma mansoni	ephrin receptor	0.0174	0.3169	0.2445
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0174	0.3169	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0174	0.3169	0.2445
Echinococcus multilocularis	NCK adaptor protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	GTPase activating protein	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0447	1	1
Echinococcus granulosus	N chimaerin	0.0273	0.5637	0.5175
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.0959	0.3025
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Echinococcus multilocularis	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Echinococcus granulosus	growth factor receptor bound protein 2	0.0273	0.5637	0.5175
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0174	0.3169	0.2445
Echinococcus granulosus	tyrosine protein kinase csk	0.0174	0.3169	0.2445
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0053	0.0143	0.0451
Brugia malayi	Tensin	0.0273	0.5637	0.5175
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0447	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0174	0.3169	1
Echinococcus granulosus	NCK adaptor protein	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Loa Loa (eye worm)	TK protein kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0273	0.5637	0.5175
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0273	0.5637	0.5175
Brugia malayi	Protein kinase domain containing protein	0.0447	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0174	0.3169	0.2445
Giardia lamblia	Protein 21.1	0.0174	0.3169	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0273	0.5637	0.5175
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0273	0.5637	0.5175
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0174	0.3169	0.2445
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3169	0.2445
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0086	0.0959	0.3025
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445
Trypanosoma cruzi	protein kinase, putative	0.0174	0.3169	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.5637	0.5175
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0273	0.5637	0.5175
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0174	0.3169	1
Trichomonas vaginalis	TKL family protein kinase	0.0174	0.3169	1
Schistosoma mansoni	tyrosine protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0447	1	1
Schistosoma mansoni	tyrosine kinase	0.0174	0.3169	0.2445
Schistosoma mansoni	protein kinase	0.0174	0.3169	0.2445
Brugia malayi	Protein kinase domain containing protein	0.0174	0.3169	0.2445

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 uM	Displacement of FITC-labeled (+)-JQ1 from bromodomain BRD4(1) (unknown origin) expressed in Escherichia coli BL21(DE3) after 4 hrs by fluorescence anisotropy assay	ChEMBL.	23530754

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2349358

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1755420