Detailed information for compound 1755574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.547 | Formula: C25H33N3O4
  • H donors: 1 H acceptors: 1 LogP: 2.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1C(=O)NCCN1Cc1ccc2c(c1)CN(CCO2)Cc1ccc(cc1OC)OC
  • InChi: 1S/C25H33N3O4/c1-4-22-25(29)26-9-10-28(22)15-18-5-8-23-20(13-18)17-27(11-12-32-23)16-19-6-7-21(30-2)14-24(19)31-3/h5-8,13-14,22H,4,9-12,15-17H2,1-3H3,(H,26,29)
  • InChiKey: SWSISSHEQPNNTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0882 0.1839 0.7893
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0422 0.0856 0.0853
Echinococcus multilocularis notch 0.1053 0.2203 0.22
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0186 0.0352 0.132
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0023 0.002
Brugia malayi nuclear hormone receptor 0.0032 0.0023 0.0023
Entamoeba histolytica acetyltransferase, putative 0.008 0.0126 0.0254
Onchocerca volvulus 0.0232 0.0451 0.0448
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0023 0.002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0055 1
Loa Loa (eye worm) animal heme peroxidase 0.4705 1 1
Loa Loa (eye worm) animal heme peroxidase 0.4705 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0046 0.0053 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0023 0.002
Schistosoma mansoni notch 0.1053 0.2203 0.22
Trichomonas vaginalis AGC family protein kinase 0.0422 0.0856 0.225
Mycobacterium leprae Probable transmembrane transport protein 0.0268 0.0528 0.1751
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0772 0.1604 0.6855
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1242 0.2607 0.2604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0023 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0023 0.002
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0147 0.027 0.0969
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0046 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0031 0.0021 0.0018
Brugia malayi Muscle positioning protein 4 0.1053 0.2203 0.2203
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0023 0.0023
Plasmodium vivax sulfate transporter, putative 0.0037 0.0034 0.1523
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0065 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0023 0.0023
Echinococcus granulosus carbonic anhydrase 0.06 0.1237 0.1234
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0095
Echinococcus multilocularis protein jagged 2 0.1053 0.2203 0.22
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.0143 0.0261 0.0258
Loa Loa (eye worm) calcium channel 0.0046 0.0053 0.005
Brugia malayi Cadherin domain containing protein 0.1053 0.2203 0.2203
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0023 0.0023
Onchocerca volvulus Peroxidase homolog 0.4705 1 1
Echinococcus granulosus neural cadherin 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0134 0.0131
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0023 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0275 0.0542 0.0539
Plasmodium falciparum carbonic anhydrase 0.06 0.1237 1
Brugia malayi Animal haem peroxidase family protein 0.4705 1 1
Loa Loa (eye worm) serotonin transporter b 0.0275 0.0542 0.0539
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.06 0.1237 0.1237
Giardia lamblia High cysteine protein 0.1053 0.2203 0.5
Echinococcus multilocularis mitogen activated protein kinase 11 0.0147 0.027 0.0266
Echinococcus granulosus protein jagged 1 0.1053 0.2203 0.22
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0055 0.0052
Mycobacterium ulcerans hypothetical protein 0.0046 0.0053 0.0102
Echinococcus multilocularis mitogen activated protein kinase 14 0.0147 0.027 0.0266
Echinococcus multilocularis voltage dependent calcium channel 0.0046 0.0053 0.005
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0051 0.0065 0.014
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1387 0.2916 1
Loa Loa (eye worm) CYP4Cod1 0.003 0.0019 0.0015
Echinococcus granulosus notch 0.1053 0.2203 0.22
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0053 0.0134
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0065 0.0061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Onchocerca volvulus 0.1053 0.2203 0.22
Schistosoma mansoni voltage-gated cation channel 0.0046 0.0053 0.005
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.1076 0.2252 0.2249
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1242 0.2607 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0023 0.0023
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0046 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Echinococcus granulosus protein jagged 2 0.1053 0.2203 0.22
Echinococcus granulosus carbonic anhydrase 0.06 0.1237 0.1234
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0023 0.002
Onchocerca volvulus 0.1053 0.2203 0.22
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0023 0.002
Echinococcus multilocularis fibropellin Ia 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Echinococcus granulosus fibropellin Ia 0.1053 0.2203 0.22
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0542 0.0539
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Brugia malayi Animal haem peroxidase family protein 0.4705 1 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0037 0.0034 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0019 0.0015
Schistosoma mansoni carbonic anhydrase-related 0.06 0.1237 0.1234
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0065 0.0061
Brugia malayi Animal haem peroxidase family protein 0.4705 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.1053 0.2203 0.2203
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0268 0.0528 0.2097
Schistosoma mansoni thyroid hormone receptor 0.0175 0.0328 0.0325
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0246 0.0482 0.0479
Echinococcus multilocularis neurogenic locus protein delta 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0275 0.0542 0.0539
Toxoplasma gondii MAPEG family protein 0.0246 0.0482 0.2063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.0541 0.0537
Onchocerca volvulus Dual oxidase homolog 0.4705 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Brugia malayi nuclear receptor NHR-88 0.0032 0.0023 0.0023
Loa Loa (eye worm) blistered cuticle protein 3 0.4705 1 1
Echinococcus granulosus serotonin transporter 0.0275 0.0542 0.0539
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.1053 0.2203 0.22
Toxoplasma gondii hypothetical protein 0.004 0.0041 0.0032
Loa Loa (eye worm) notch protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0023 0.0023
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0046 0.0053 0.005
Onchocerca volvulus 0.1053 0.2203 0.22
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1242 0.2607 0.2607
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0023 0.002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Schistosoma mansoni cell polarity protein 0.1053 0.2203 0.22
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.06 0.1237 0.1237
Loa Loa (eye worm) solute carrier family 6 member 4 0.0275 0.0542 0.0539
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Brugia malayi Blistered cuticle protein 3 0.4705 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0023 0.002
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0422 0.0856 0.0853
Echinococcus multilocularis protein jagged 1 0.1053 0.2203 0.22
Echinococcus multilocularis mitogen activated protein kinase 14 0.0147 0.027 0.0266
Entamoeba histolytica protein kinase, putative 0.0422 0.0856 0.2804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0023 0.002
Onchocerca volvulus Chorion peroxidase homolog 0.4705 1 1
Plasmodium falciparum transporter, putative 0.0047 0.0055 0.042
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Toxoplasma gondii hypothetical protein 0.0047 0.0055 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0055 0.0052
Echinococcus multilocularis serotonin transporter 0.0275 0.0542 0.0539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0023 0.002
Brugia malayi Delta serrate ligand family protein 0.1053 0.2203 0.2203
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0037 0.0034 0.0046
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0023 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0023 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0023 0.002
Mycobacterium ulcerans transferase 0.0077 0.012 0.0299
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0134 0.0242 0.0238
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0051 0.0065 0.3006
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0046 0.0053 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0053 0.0134
Brugia malayi Calcium binding EGF domain containing protein 0.1053 0.2203 0.2203
Trichomonas vaginalis conserved hypothetical protein 0.161 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.1272 0.2672 0.267
Echinococcus granulosus slit 2 protein 0.1053 0.2203 0.22
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0023 0.002
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Echinococcus granulosus carbonic anhydrase II 0.1242 0.2607 0.2604
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0023 0.002
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0046 0.0053 0.005
Echinococcus multilocularis neurogenic locus notch protein 4 0.1053 0.2203 0.22
Leishmania major carbonic anhydrase family protein, putative 0.1387 0.2916 1
Echinococcus granulosus carbonic anhydrase 0.06 0.1237 0.1234
Schistosoma mansoni lipoxygenase 0.0134 0.0242 0.0238
Brugia malayi Protein kinase domain containing protein 0.0422 0.0856 0.0856
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0023 0.002
Echinococcus multilocularis geminin 0.0193 0.0367 0.0363
Onchocerca volvulus Putative sulfate transporter 0.0232 0.0451 0.0448
Echinococcus granulosus neurogenic locus notch protein 4 0.1053 0.2203 0.22
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0023 0.002
Echinococcus granulosus geminin 0.0193 0.0367 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0053 0.0134
Mycobacterium ulcerans epoxide hydrolase EphA 0.0186 0.0352 0.0988
Echinococcus granulosus neurogenic locus notch protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Schistosoma mansoni notch 0.1053 0.2203 0.22
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.06 0.1237 0.1234
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Mycobacterium ulcerans carbonic anhydrase 0.161 0.3393 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1242 0.2607 1
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.008 0.0126 0.0322
Onchocerca volvulus 0.4705 1 1
Brugia malayi Cytochrome P450 family protein 0.0083 0.0132 0.0132
Schistosoma mansoni notch 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Schistosoma mansoni septate junction protein 0.1053 0.2203 0.22
Onchocerca volvulus Neurogenic locus notch protein homolog 0.1053 0.2203 0.22
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0422 0.0856 0.0853
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0023 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0023 0.002
Echinococcus granulosus dynactin 5 p25 0.008 0.0126 0.0123
Onchocerca volvulus 0.1053 0.2203 0.22
Toxoplasma gondii hypothetical protein 0.06 0.1237 0.5544
Brugia malayi notch-like transmembrane receptor 0.1053 0.2203 0.2203
Schistosoma mansoni notch 0.1053 0.2203 0.22
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0037 0.0034 0.006
Echinococcus granulosus protein jagged 2 0.1053 0.2203 0.22
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0037 0.0034 0.0046
Onchocerca volvulus Peroxidasin homolog 0.4705 1 1
Mycobacterium ulcerans carbonic anhydrase 0.1387 0.2916 0.8587
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0055 0.0052
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0134 0.0131
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0051 0.0065 0.0136
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0055 0.0052
Brugia malayi GCC2 and GCC3 family protein 0.1053 0.2203 0.2203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0023 0.002
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0046 0.0053 0.0133
Schistosoma mansoni peroxidasin 0.4705 1 1
Echinococcus multilocularis carbonic anhydrase 0.06 0.1237 0.1234
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Treponema pallidum sodium- and chloride- dependent transporter 0.0275 0.0542 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0038
Onchocerca volvulus 0.0051 0.0065 0.0061
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0023 0.0023
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0095
Schistosoma mansoni notch 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.06 0.1237 0.1234
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0023 0.002
Onchocerca volvulus Putative cubilin 0.1053 0.2203 0.22
Echinococcus multilocularis carbonic anhydrase II 0.1242 0.2607 0.2604
Onchocerca volvulus Peroxidasin homolog 0.4705 1 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0095
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0023 0.0023
Schistosoma mansoni carbonic anhydrase 0.06 0.1237 0.1234
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0023 0.002
Brugia malayi Cytochrome P450 family protein 0.003 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Echinococcus granulosus mitogen activated protein kinase 11 0.0147 0.027 0.0266
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0055 0.2534
Loa Loa (eye worm) voltage-dependent calcium channel 0.0046 0.0053 0.005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.0261 0.0258
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.008 0.0126 0.2761
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0023 0.002
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0147 0.027 0.0969
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1242 0.2607 0.2607
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0046 0.0053 0.005
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0037 0.0034 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0023 0.0023
Echinococcus multilocularis fat cadherin tumor suppressor 0.1053 0.2203 0.22
Echinococcus multilocularis thyroid hormone receptor alpha 0.0175 0.0328 0.0325
Echinococcus multilocularis neural cadherin 0.1053 0.2203 0.22
Brugia malayi Animal haem peroxidase family protein 0.4705 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0055 0.0052
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0422 0.0856 0.225
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0169 0.0317 1
Schistosoma mansoni coup transcription factor 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Echinococcus multilocularis carbonic anhydrase 0.06 0.1237 0.1234
Loa Loa (eye worm) norepinephrine transporter 0.0275 0.0542 0.0539
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0055 0.0052
Onchocerca volvulus 0.1053 0.2203 0.22
Onchocerca volvulus 0.0275 0.0542 0.0539
Schistosoma mansoni cytochrome c oxidase subunit II 0.0139 0.0251 0.0248
Brugia malayi Calcium binding EGF domain containing protein 0.1053 0.2203 0.2203
Brugia malayi hypothetical protein 0.0047 0.0055 0.0055
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0046 0.0053 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0023 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0023 0.002
Brugia malayi Peroxidasin 0.4705 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0046 0.0053 0.005
Entamoeba histolytica ankyrin, putative 0.008 0.0126 0.0255
Onchocerca volvulus 0.0047 0.0055 0.0052
Brugia malayi P38 map kinase family protein 2 0.0147 0.027 0.027
Brugia malayi Cadherin domain containing protein 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0051 0.0065 0.0498
Echinococcus multilocularis mitogen activated protein kinase 11 0.0147 0.027 0.0266
Brugia malayi hypothetical protein 0.0022 0.0003 0.0003
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0055 0.0052
Onchocerca volvulus Neurogenic locus notch homolog 0.1053 0.2203 0.22
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0046 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.005
Loa Loa (eye worm) carbonic anhydrase 3 0.1242 0.2607 0.2604
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0023 0.002
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0275 0.0542 0.0539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0023 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0023 0.002
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1106 0.2316 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0118 0.0208 1
Plasmodium vivax amine transporter, putative 0.0047 0.0055 0.2534
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Brugia malayi Animal haem peroxidase family protein 0.4705 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0019 0.0015
Loa Loa (eye worm) Notch2 0.1053 0.2203 0.22
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0055 0.0052
Schistosoma mansoni carbonic anhydrase-related 0.06 0.1237 0.1234
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0147 0.027 0.0866
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.06 0.1237 0.1237
Echinococcus granulosus voltage dependent calcium channel 0.0046 0.0053 0.005
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0147 0.027 0.0266
Schistosoma mansoni hypothetical protein 0.0193 0.0367 0.0363
Trypanosoma brucei carbonic anhydrase-like protein 0.1242 0.2607 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.06 0.1237 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0023 0.0023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0422 0.0856 0.225
Trichomonas vaginalis conserved hypothetical protein 0.161 0.3393 1
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0542 0.0539
Onchocerca volvulus 0.4705 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0046 0.0053 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0023 0.002
Toxoplasma gondii hypothetical protein 0.0047 0.0055 0.0095
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Schistosoma mansoni hypothetical protein 0.06 0.1237 0.1234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Schistosoma mansoni slit 0.1053 0.2203 0.22
Leishmania major carbonic anhydrase-like protein 0.1242 0.2607 0.8933
Echinococcus granulosus cytochrome c oxidase subunit II 0.0169 0.0317 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0023 0.0023
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.0261 0.0258
Schistosoma mansoni carbonic anhydrase 0.1387 0.2916 0.2913
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0023 0.0023
Onchocerca volvulus 0.0047 0.0055 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Toxoplasma gondii EGF family domain-containing protein 0.1053 0.2203 1
Loa Loa (eye worm) animal heme peroxidase 0.4705 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0053 0.005
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0422 0.0856 0.0853
Brugia malayi phosphoinositide-dependent protein kinase I 0.0422 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0038
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.1053 0.2203 0.22
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0055 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0023 0.0023
Schistosoma mansoni peroxidasin 0.4705 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0046 0.0053 0.005
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.06 0.1237 0.1234
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1242 0.2607 0.2604
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0051 0.0065 0.0061
Brugia malayi Doublecortin family protein 0.0022 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0193 0.0367 0.0363
Schistosoma mansoni sodium/chloride dependent transporter 0.0051 0.0065 0.0061
Onchocerca volvulus 0.0047 0.0055 0.0052
Brugia malayi hypothetical protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Mycobacterium ulcerans integral membrane transporter 0.0037 0.0034 0.0046
Echinococcus multilocularis neurogenic locus protein delta 0.1053 0.2203 0.22
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0023 0.002
Schistosoma mansoni thyroid hormone receptor 0.0175 0.0328 0.0325
Onchocerca volvulus 0.0032 0.0023 0.002
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0051 0.0065 0.005
Onchocerca volvulus Slit protein homolog 0.1053 0.2203 0.22
Schistosoma mansoni notch 0.1053 0.2203 0.22
Echinococcus multilocularis slit 2 protein 0.1053 0.2203 0.22
Onchocerca volvulus 0.4705 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Echinococcus granulosus delta-like protein 1 0.1053 0.2203 0.22
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0055 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0422 0.0856 0.0853
Brugia malayi steroid hormone receptor 0.0032 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.1053 0.2203 0.22
Onchocerca volvulus 0.0077 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Echinococcus granulosus neurogenic locus protein delta 0.1053 0.2203 0.22
Echinococcus multilocularis carbonic anhydrase 0.06 0.1237 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0023 0.0023
Entamoeba histolytica carbonic anhydrase, putative 0.1387 0.2916 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0055 0.0052
Echinococcus granulosus protein jagged 1 0.1053 0.2203 0.22
Echinococcus multilocularis neurogenic locus notch protein 0.1053 0.2203 0.22
Echinococcus multilocularis protein jagged 1 0.1053 0.2203 0.22
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0055 0.0052
Onchocerca volvulus Peroxidase homolog 0.4705 1 1
Brugia malayi follicle stimulating hormone receptor 0.0274 0.0541 0.0541
Echinococcus multilocularis peroxidasin 0.4705 1 1
Mycobacterium leprae PROBABLE TRANSFERASE 0.0077 0.012 0.0341
Echinococcus granulosus microsomal glutathione S transferase 3 0.0246 0.0482 0.0479
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.008 0.0126 0.2761
Leishmania major hypothetical protein, conserved 0.0046 0.0053 0.0119
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0134 0.0242 0.0238
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0055 0.0052
Schistosoma mansoni cytochrome-c oxidase 0.0051 0.0065 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0023 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0132 0.0128
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0046 0.0053 0.0133
Brugia malayi EGF-like domain containing protein 0.1053 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.002
Schistosoma mansoni microsomal glutathione s-transferase 0.0246 0.0482 0.0479
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0147 0.027 0.0969
Loa Loa (eye worm) hypothetical protein 0.4705 1 1
Echinococcus granulosus neurogenic locus notch protein 0.1053 0.2203 0.22
Brugia malayi Cytochrome P450 family protein 0.003 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Schistosoma mansoni laminin gamma-3 chain 0.1053 0.2203 0.22
Echinococcus granulosus mitogen activated protein kinase 14 0.0147 0.027 0.0266
Schistosoma mansoni lipoxygenase 0.0094 0.0156 0.0152
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0055 0.042
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0037 0.0034 0.006
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0055 0.0052
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1242 0.2607 0.2604
Schistosoma mansoni carbonic anhydrase-related 0.06 0.1237 0.1234
Loa Loa (eye worm) hypothetical protein 0.1053 0.2203 0.22
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0046 0.0053 0.0053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.06 0.1237 0.1237
Brugia malayi ecdysteroid receptor 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0055 0.0052
Echinococcus granulosus peroxidasin 0.4705 1 1
Loa Loa (eye worm) animal heme peroxidase 0.4705 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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