Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0107 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.437 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.437 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.437 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.437 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.437 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.437 | 0.437 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.437 | 0.437 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.437 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0107 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.437 | 0.437 |
Giardia lamblia | Kinase, AGC AKT | 0.0092 | 0.8333 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0092 | 0.8333 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.437 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.437 | 0.437 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0092 | 0.8333 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.437 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.437 | 0.437 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.437 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.437 | 0.5244 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.437 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.437 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.437 | 0.437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.