Detailed information for compound 1755713

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.655 | Formula: C26H38N2O5S
  • H donors: 1 H acceptors: 4 LogP: 3.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](N1C[C@H](C)[C@H](CN(C(=O)C2CCC2)C)Oc2c(S1(=O)=O)ccc(c2)C#CCC(C)C)C
  • InChi: 1S/C26H38N2O5S/c1-18(2)8-6-9-21-12-13-25-23(14-21)33-24(16-27(5)26(30)22-10-7-11-22)19(3)15-28(20(4)17-29)34(25,31)32/h12-14,18-20,22,24,29H,7-8,10-11,15-17H2,1-5H3/t19-,20+,24-/m0/s1
  • InChiKey: VCSDNDWRGCVVOZ-ROKPMTFOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0042 0.0056
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0019 0.0026
Brugia malayi PDZ domain containing protein 0.0025 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0865 0.114 0.1694
Echinococcus multilocularis 0.0045 0.0036 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0865 0.114 0.1524
Brugia malayi Calcitonin receptor-like protein seb-1 0.2734 0.3656 0.3656
Mycobacterium leprae Probable Holliday junction DNA helicase component RuvA 0.0032 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) neuropeptide F receptor 0.0196 0.024 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus multilocularis g protein coupled receptor 0.0196 0.024 0.0321
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0042 0.0062
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2389 0.3192 1
Trypanosoma brucei Heat shock protein 83, putative 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis serotonin receptor 0.0196 0.024 0.0321
Echinococcus multilocularis G protein coupled receptor 139 0.3556 0.4764 0.6365
Schistosoma mansoni biogenic amine receptor 0.0196 0.024 0.0356
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0196 0.024 0.024
Onchocerca volvulus 0.0196 0.024 1
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Echinococcus granulosus tm gpcr rhodopsin 0.0196 0.024 0.0321
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0196 0.024 0.0321
Echinococcus multilocularis neuropeptide Y receptor 0.0196 0.024 0.0321
Plasmodium vivax heat shock protein, putative 0.004 0.003 0.1743
Schistosoma mansoni amine GPCR 0.0196 0.024 0.0356
Toxoplasma gondii DNA repair protein rad10 subfamily protein 0.0032 0.002 0.1093
Toxoplasma gondii Hsp90 domain-containing protein 0.004 0.003 0.1743
Onchocerca volvulus 0.0196 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0019 0.0026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0196 0.024 0.024
Echinococcus granulosus G protein coupled receptor 139 0.0196 0.024 0.0321
Schistosoma mansoni neuropeptide receptor 0.0196 0.024 0.0356
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis insulin receptor 0.0046 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus glutamate NMDA receptor subunit 0.0273 0.0343 0.0459
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni opsin-like receptor 0.0196 0.024 0.0356
Plasmodium falciparum heat shock protein 90 0.0135 0.0158 1
Echinococcus granulosus g-protein coupled receptor 0.0196 0.024 0.0321
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0196 0.024 0.0356
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0196 0.024 0.0321
Echinococcus granulosus sex peptide receptor 0.0196 0.024 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0196 0.024 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Echinococcus multilocularis G-protein coupled receptor, putative 0.0196 0.024 0.0321
Echinococcus multilocularis serotonin receptor 0.0196 0.024 0.0321
Trichomonas vaginalis heat shock protein, putative 0.0135 0.0158 1
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Schistosoma mansoni hypothetical protein 0.0865 0.114 0.1694
Echinococcus multilocularis neuropeptides capa receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.0171 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0196 0.024 0.024
Echinococcus granulosus neuropeptide Y receptor 0.0196 0.024 0.0321
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0034 0.0022 0.0033
Mycobacterium tuberculosis Probable holliday junction DNA helicase RuvA 0.0032 0.002 0.0053
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0042 0.0056
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.0009 0.0012
Schistosoma mansoni endoplasmin 0.0135 0.0158 0.0235
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0196 0.024 0.0321
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.5577 0.7484 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Mycobacterium ulcerans Holliday junction DNA helicase RuvA 0.0032 0.002 0.0053
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0196 0.024 0.0321
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0131 0.0175
Schistosoma mansoni cpg binding protein 0.003 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0196 0.024 0.0356
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0003 0.011
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0028
Schistosoma mansoni hypothetical protein 0.0865 0.114 0.1694
Echinococcus multilocularis somatostatin receptor 0.0196 0.024 0.0321
Schistosoma mansoni neuropeptide F-like receptor 0.0196 0.024 0.0356
Plasmodium falciparum endoplasmin, putative 0.006 0.0056 0.3465
Schistosoma mansoni excision repair cross-complementing 1 ercc1 0.0032 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0196 0.024 0.0321
Giardia lamblia hypothetical protein 0.0032 0.002 0.1093
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0273 0.0343 0.0459
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus DNA excision repair protein ERCC 1 0.0032 0.002 0.0026
Brugia malayi follicle stimulating hormone receptor 0.0196 0.024 0.024
Loa Loa (eye worm) G-protein coupled receptor 0.0196 0.024 0.024
Loa Loa (eye worm) TOPoisomerase family member 0.002 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0019 0.0029
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0034 0.0022 0.003
Brugia malayi kinase, mitochondrial precursor 0.002 0.0003 0.0003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0196 0.024 0.0321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0042 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Trypanosoma cruzi heat shock protein 90, putative 0.0095 0.0104 0.6535
Schistosoma mansoni histamine h1 receptor 0.0196 0.024 0.0356
Echinococcus granulosus dnaJ subfamily B 0.043 0.0555 0.0742
Echinococcus multilocularis g protein coupled receptor 0.0196 0.024 0.0321
Chlamydia trachomatis DNA ligase 0.0032 0.002 0.1998
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.004 0.003 0.1238
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0196 0.024 0.0321
Echinococcus granulosus neuropeptide FF receptor 2 0.0196 0.024 0.0321
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.0009 0.0013
Echinococcus multilocularis GPCR, family 2 0.0865 0.114 0.1524
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0048 0.004 0.2427
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0042 0.0056
Chlamydia trachomatis exodeoxyribonuclease V subunit alpha 0.0032 0.002 0.1998
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0019 0.0029
Loa Loa (eye worm) heat shock protein 90 0.0135 0.0158 0.0158
Brugia malayi Dopamine receptor 0.0196 0.024 0.024
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0196 0.024 0.0356
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0196 0.024 0.0356
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Schistosoma mansoni cpg binding protein 0.0032 0.0019 0.0028
Echinococcus multilocularis orexin receptor type 2 0.0196 0.024 0.0321
Schistosoma mansoni tyrosine kinase 0.0145 0.0171 0.0254
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Echinococcus granulosus somatostatin receptor 0.0196 0.024 0.0321
Echinococcus multilocularis neuropeptide Y receptor 0.0196 0.024 0.0321
Echinococcus granulosus heat shock protein 90 0.0135 0.0158 0.0211
Chlamydia trachomatis Holliday junction ATP-dependent DNA helicase RuvA 0.0032 0.002 0.1998
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0017 0.0017
Onchocerca volvulus 0.0196 0.024 1
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0048 0.004 0.2427
Chlamydia trachomatis glutamine binding protein 0.0083 0.0088 1
Brugia malayi Dopamine receptor protein 1 0.0196 0.024 0.024
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.7446 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0196 0.024 0.0321
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) endoplasmin 0.0135 0.0158 0.0158
Brugia malayi Serotonin receptor 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0865 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Onchocerca volvulus 0.003 0.0017 0.069
Echinococcus multilocularis NMDA receptor 0.0032 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Trichomonas vaginalis heat shock protein, putative 0.006 0.0056 0.3465
Schistosoma mansoni hypothetical protein 0.0865 0.114 0.1694
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0019 0.0026
Plasmodium vivax heat shock protein 90, putative 0.004 0.003 0.1743
Echinococcus multilocularis neuropeptide receptor 0.3556 0.4764 0.6365
Brugia malayi putative neuropeptide receptor 0.0196 0.024 0.024
Schistosoma mansoni heat shock protein 0.0135 0.0158 0.0235
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi GnHR receptor homolog 0.0196 0.024 0.024
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0083 0.0088 0.6608
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0019 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0196 0.024 0.0321
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0083 0.0088 1
Onchocerca volvulus 0.0196 0.024 1
Echinococcus multilocularis DNA excision repair protein ERCC 1 0.0032 0.002 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.1869 0.2492 0.2492
Echinococcus granulosus neuropeptide receptor 0.0196 0.024 0.0321
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0196 0.024 0.0321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0042 0.0056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0196 0.024 0.024
Schistosoma mansoni neuropeptide f receptor 76f 0.0196 0.024 0.0356
Echinococcus granulosus hypothetical protein 0.0196 0.024 0.0321
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0048 0.004 0.2427
Schistosoma mansoni pyruvate dehydrogenase 0.002 0.0003 0.0004
Schistosoma mansoni neuropeptide receptor 0.0196 0.024 0.0356
Echinococcus multilocularis 0.0034 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0865 0.114 0.1524
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0196 0.024 0.0356
Trypanosoma cruzi heat shock protein 90, putative 0.0115 0.0131 0.8278
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0115 0.0131 0.0175
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Treponema pallidum Holliday junction DNA helicase (ruvA) 0.0032 0.002 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Giardia lamblia Heat shock protein HSP 90-alpha 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.0158 1
Brugia malayi Melatonin receptor type 1A 0.0196 0.024 0.024
Echinococcus granulosus 7tm_1 domain containing protein 0.0196 0.024 0.0321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0009
Onchocerca volvulus Neuropeptide F receptor homolog 0.0196 0.024 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0042 0.0056
Schistosoma mansoni tyrosine kinase 0.0046 0.0038 0.0057
Schistosoma mansoni alpha-1 adrenergic receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0053 0.3237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0196 0.024 0.0321
Schistosoma mansoni neuropeptide receptor 0.3556 0.4764 0.7075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0196 0.024 0.0321
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.002 0.0003 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Echinococcus granulosus g protein coupled receptor 0.0196 0.024 0.0321
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0083 0.0088 0.0266
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus granulosus alpha 1A adrenergic receptor 0.0196 0.024 0.0321
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0196 0.024 0.024
Schistosoma mansoni tyrosine kinase 0.0046 0.0038 0.0057
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0038 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Toxoplasma gondii heat shock protein HSP90 0.0135 0.0158 1
Echinococcus granulosus g protein coupled receptor 0.0196 0.024 0.0321
Schistosoma mansoni tyrosine kinase 0.0078 0.0081 0.012
Brugia malayi RE15519p 0.0196 0.024 0.024
Schistosoma mansoni serine-type protease inhibitor 0.5019 0.6733 1
Echinococcus granulosus glutamate receptor 2 0.0049 0.0042 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Schistosoma mansoni hypothetical protein 0.043 0.0555 0.0824
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0131 0.0175
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Wolbachia endosymbiont of Brugia malayi Holliday junction DNA helicase RuvA 0.0032 0.002 0.132
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0196 0.024 0.0356
Echinococcus granulosus dna repair protein rad51 1 0.0048 0.004 0.0054
Schistosoma mansoni heat shock protein 0.004 0.003 0.0044
Schistosoma mansoni opsin-like receptor 0.0196 0.024 0.0356
Echinococcus granulosus DNA topoisomerase 2 alpha 0.002 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0196 0.024 0.0356
Brugia malayi DNA topoisomerase II, alpha isozyme 0.002 0.0003 0.0003
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0081 0.0108
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0196 0.024 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0196 0.024 0.024
Schistosoma mansoni biogenic amine (5HT) receptor 0.0196 0.024 0.0356
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni tyrosine kinase 0.0077 0.008 0.0118
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0003 0.0004
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0019 0.0019
Echinococcus granulosus cpg binding protein 0.0032 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Entamoeba histolytica heat shock protein 90, putative 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0083 0.0088 0.0266
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi AKH receptor 0.0196 0.024 0.024
Schistosoma mansoni DNA topoisomerase II 0.002 0.0003 0.0004
Schistosoma mansoni glutamate receptor NMDA 0.0273 0.0343 0.051
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0196 0.024 0.0356
Echinococcus multilocularis dna repair protein rad51 1 0.0048 0.004 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0025 0.0009 0.0012
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Brugia malayi heat shock protein 90 0.0135 0.0158 0.0158
Onchocerca volvulus DNA topoisomerase 2 homolog 0.002 0.0003 0.011
Echinococcus granulosus dro:myosuppressin receptor 0.0196 0.024 0.0321
Echinococcus granulosus neuropeptide s receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0038 0.0038
Onchocerca volvulus 0.0196 0.024 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0019 0.0026
Echinococcus multilocularis allatostatin A receptor 0.0196 0.024 0.0321
Plasmodium falciparum heat shock protein 90, putative 0.004 0.003 0.1743
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0196 0.024 0.0356
Echinococcus granulosus GPCR family 2 0.0865 0.114 0.1524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Loa Loa (eye worm) heat shock protein 75 0.004 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0131 0.8278
Echinococcus granulosus allatostatin A receptor 0.0196 0.024 0.0321
Brugia malayi Dopamine receptor protein 2 0.0196 0.024 0.024
Schistosoma mansoni heat shock protein 0.0135 0.0158 0.0235
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0115 0.0131 1
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0196 0.024 0.024
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0131 0.8278
Echinococcus granulosus peptide allatostatin:somatostatin 0.0196 0.024 0.0321
Leishmania major RAD51/dmc1 protein 0.0048 0.004 0.2427
Brugia malayi neuropeptide F receptor 0.0196 0.024 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Plasmodium vivax heat shock protein 86, putative 0.0135 0.0158 1
Schistosoma mansoni biogenic amine receptor 0.0196 0.024 0.0356
Brugia malayi sulfakinin receptor protein 0.0196 0.024 0.024
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus multilocularis fmrfamide receptor 0.0196 0.024 0.0321
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0115 0.0131 0.0403
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0196 0.024 0.0321
Echinococcus multilocularis dnaJ subfamily B 0.043 0.0555 0.0742
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.002 0.0003 0.0004
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0865 0.114 0.114
Schistosoma mansoni serine-type protease inhibitor 0.5019 0.6733 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0196 0.024 0.0321
Loa Loa (eye worm) TYRA-2 protein 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2389 0.3192 1
Trichomonas vaginalis endoplasmin, putative 0.006 0.0056 0.3465
Trypanosoma brucei heat shock protein 84, putative 0.004 0.003 0.1743
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Echinococcus multilocularis heat shock protein 90 0.0135 0.0158 0.0211
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni amine GPCR 0.0196 0.024 0.0356
Onchocerca volvulus 0.0196 0.024 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0196 0.024 0.0321
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0025 0.0009 0.0012
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0019 0.0026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0196 0.024 0.024
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.0048 0.004 0.2427
Loa Loa (eye worm) hypothetical protein 0.1869 0.2492 0.2492
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus biogenic amine 5HT receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Treponema pallidum heat shock protein 90 0.0115 0.0131 1
Brugia malayi Protein kinase domain containing protein 0.0046 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0196 0.024 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Brugia malayi G protein-coupled receptor 0.0196 0.024 0.024
Toxoplasma gondii heat shock protein 90, putative 0.0135 0.0158 1
Echinococcus granulosus serotonin receptor 0.0196 0.024 0.0321
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0196 0.024 0.0321
Trypanosoma cruzi Heat shock protein 83, putative 0.0135 0.0158 1
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.0171 0.0171
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.002 0.0003 0.0004
Echinococcus granulosus orexin receptor type 2 0.0196 0.024 0.0321
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0196 0.024 0.0356
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.0158 1
Echinococcus multilocularis heat shock protein 90 0.0115 0.0131 0.0175
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0019 0.0026
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0115 0.0131 0.8278
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0081 0.0108
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0196 0.024 0.0356
Brugia malayi Probable DNA topoisomerase II 0.002 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Echinococcus multilocularis g-protein coupled receptor 0.0196 0.024 0.0321
Echinococcus multilocularis neuropeptide receptor 0.0196 0.024 0.0321
Echinococcus multilocularis fmrfamide receptor 0.0196 0.024 0.0321
Schistosoma mansoni hypothetical protein 0.0032 0.0019 0.0029
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi Serotonin receptor 0.0196 0.024 0.024
Brugia malayi Hsp90 protein 0.004 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0081 0.0108
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni myosin xvIII 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Trypanosoma brucei heat shock protein 90, putative 0.0135 0.0158 1
Schistosoma mansoni endoplasmin 0.0135 0.0158 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Giardia lamblia DNA helicase 0.0032 0.002 0.1093
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Echinococcus multilocularis sex peptide receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Brugia malayi G-protein coupled receptor 0.0196 0.024 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0062 0.0092
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.0048 0.004 0.2427
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Echinococcus multilocularis g protein coupled receptor 0.0196 0.024 0.0321
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0196 0.024 0.024
Mycobacterium ulcerans heat shock protein 90 0.0115 0.0131 0.0403
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0025 0.0009 0.0012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0131 0.0175
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0042 0.0056
Trypanosoma cruzi heat shock protein 85, putative 0.0115 0.0131 0.8278
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0019 0.0029
Echinococcus granulosus endoplasmin 0.0115 0.0131 0.0175
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0019 0.0019
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.004 0.003 0.004
Plasmodium falciparum heat shock protein 90, putative 0.004 0.003 0.1743
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.5577 0.7484 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Brugia malayi neuropeptide F receptor 0.0196 0.024 0.024
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0019 0.0029
Echinococcus multilocularis dro:myosuppressin receptor 0.0196 0.024 0.0321
Brugia malayi CXXC zinc finger family protein 0.003 0.0017 0.0017
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi hypothetical protein 0.0196 0.024 0.024
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0048 0.004 0.2427
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0196 0.024 0.024
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0083 0.0088 0.6608
Echinococcus granulosus g protein coupled receptor 0.0196 0.024 0.0321
Giardia lamblia Heat shock protein HSP 90-alpha 0.0115 0.0131 0.8278
Schistosoma mansoni hypothetical protein 0.1869 0.2492 0.37
Brugia malayi Tachykinin-like peptides receptor 99D 0.0196 0.024 0.024
Echinococcus multilocularis endoplasmin 0.0115 0.0131 0.0175
Echinococcus granulosus neuropeptides capa receptor 0.0196 0.024 0.0321
Plasmodium vivax endoplasmin, putative 0.0135 0.0158 1
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Schistosoma mansoni tyrosine kinase 0.0077 0.008 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0865 0.114 0.114
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0042 0.0056
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0025 0.0009 0.0012
Echinococcus granulosus heat shock protein 90 0.0115 0.0131 0.0175
Brugia malayi ORL1-like opioid receptor 0.0196 0.024 0.024
Schistosoma mansoni DNA repair protein RAD51 0.0048 0.004 0.006
Onchocerca volvulus 0.0196 0.024 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0196 0.024 0.0356
Schistosoma mansoni amine GPCR 0.0196 0.024 0.0356
Entamoeba histolytica DNA repair protein RAD51, putative 0.0048 0.004 0.2427
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0196 0.024 0.024
Echinococcus multilocularis heat shock protein 0.0135 0.0158 0.0211
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Schistosoma mansoni hypothetical protein 0.0196 0.024 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Echinococcus multilocularis cpg binding protein 0.0032 0.0019 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0865 0.114 0.114
Wolbachia endosymbiont of Brugia malayi transcription elongation factor NusA 0.0032 0.002 0.132
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0196 0.024 0.0321
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.0171 0.0228
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2389 0.3192 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0196 0.024 0.0321
Onchocerca volvulus 0.0196 0.024 1
Echinococcus granulosus insulin receptor 0.0046 0.0038 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0196 0.024 0.0321
Entamoeba histolytica heat shock protein 90, putative 0.0135 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Mycobacterium ulcerans excinuclease ABC subunit C 0.0032 0.002 0.0053
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Leishmania major heat shock protein 83-1 0.0135 0.0158 1
Brugia malayi DNA repair protein RAD51 homolog 1 0.0048 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Schistosoma mansoni neuropeptide F-like receptor 0.0196 0.024 0.0356
Echinococcus granulosus fmrfamide receptor 0.0196 0.024 0.0321
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0131 0.8278
Giardia lamblia Grp94/Hsp90 0.0115 0.0131 0.8278
Echinococcus granulosus neuropeptides capa receptor 0.0196 0.024 0.0321
Echinococcus granulosus 7TM GPCR rhodopsin 0.0196 0.024 0.0321
Schistosoma mansoni biogenic amine receptor 0.0196 0.024 0.0356
Schistosoma mansoni tyrosine kinase 0.0077 0.008 0.0118
Brugia malayi putative neuropeptide receptor NPR1 0.0196 0.024 0.024
Schistosoma mansoni opsin-like receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) rad51 0.0048 0.004 0.004
Schistosoma mansoni amine GPCR 0.0196 0.024 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2734 0.3656 0.3656
Echinococcus granulosus rhodopsin orphan GPCR 0.0196 0.024 0.0321
Onchocerca volvulus 0.0196 0.024 1
Onchocerca volvulus 0.0196 0.024 1
Echinococcus granulosus heat shock protein 0.0135 0.0158 0.0211
Echinococcus granulosus neuropeptide receptor A26 0.0196 0.024 0.0321
Echinococcus granulosus neuropeptide receptor 0.3556 0.4764 0.6365
Brugia malayi Endoplasmin precursor 0.0135 0.0158 0.0158
Trypanosoma brucei heat shock protein, putative 0.0135 0.0158 1
Chlamydia trachomatis excinuclease ABC subunit C 0.0032 0.002 0.1998
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0019 0.0026
Schistosoma mansoni neuropeptide receptor 0.0196 0.024 0.0356
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.0171 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0196 0.024 0.0321
Trypanosoma brucei heat shock protein 90, putative 0.0135 0.0158 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0038 0.0051
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.004 0.003 0.004
Onchocerca volvulus 0.0196 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0196 0.024 0.0356
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0196 0.024 0.0321
Schistosoma mansoni amine GPCR 0.0196 0.024 0.0356
Schistosoma mansoni tyrosine kinase 0.0078 0.0081 0.012
Echinococcus granulosus neuropeptide Y receptor 0.0196 0.024 0.0321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0196 0.024 0.0321
Trypanosoma cruzi heat shock protein 90, putative 0.0135 0.0158 1
Brugia malayi G-protein coupled receptor 0.0196 0.024 0.024
Echinococcus granulosus biogenic amine 5HT receptor 0.0196 0.024 0.0321
Onchocerca volvulus 0.0196 0.024 1
Brugia malayi larval opioid receptor 0.0196 0.024 0.024
Leishmania major heat shock protein, putative 0.004 0.003 0.1743
Echinococcus multilocularis neuropeptides capa receptor 0.0196 0.024 0.0321
Echinococcus granulosus tm gpcr rhodopsin 0.0196 0.024 0.0321
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0115 0.0131 0.0403
Trichomonas vaginalis heat shock protein, putative 0.004 0.003 0.1743
Schistosoma mansoni adenoreceptor 0.0196 0.024 0.0356
Schistosoma mansoni biogenic amine (5HT) receptor 0.0196 0.024 0.0356
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.002 0.0003 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0196 0.024 0.0356
Toxoplasma gondii heat shock protein 75, putative 0.004 0.003 0.1743
Entamoeba histolytica 90 kDa heat shock protein, putative 0.004 0.003 0.1743
Echinococcus multilocularis rhodopsin orphan GPCR 0.0196 0.024 0.0321
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.002 0.0003 0.0003
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0196 0.024 0.024
Trypanosoma cruzi heat shock protein, putative 0.004 0.003 0.1743
Loa Loa (eye worm) neuropeptide F receptor 0.0196 0.024 0.024
Loa Loa (eye worm) melatonin receptor type 1A 0.0196 0.024 0.024

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) > 52 uM PubChem BioAssay. HeLa Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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