Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.2113 | 0.9716 | 0.9589 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1389 | 0.6264 | 0.8984 |
Trypanosoma cruzi | Protein kinase B | 0.1464 | 0.6622 | 1 |
Leishmania major | protein kinase, putative | 0.0075 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0784 | 0.3378 | 0.3378 |
Giardia lamblia | Kinase, AGC PKA | 0.1404 | 0.6338 | 0.5 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1389 | 0.6264 | 0.8984 |
Entamoeba histolytica | protein kinase 2, putative | 0.1404 | 0.6338 | 0.6338 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1464 | 0.6622 | 1 |
Leishmania major | protein kinase, putative | 0.0075 | 0 | 0.5 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1464 | 0.6622 | 1 |
Echinococcus multilocularis | nervana 2 | 0.1389 | 0.6264 | 0.8984 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1464 | 0.6622 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0075 | 0 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1464 | 0.6622 | 0.6622 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1404 | 0.6338 | 0.9195 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1464 | 0.6622 | 1 |
Leishmania major | folate/biopterin transporter, putative | 0.0075 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0724 | 0.3094 | 0.3094 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0075 | 0 | 0.5 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1404 | 0.6338 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1404 | 0.6338 | 0.9195 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1404 | 0.6338 | 0.9195 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1389 | 0.6264 | 0.8984 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.2113 | 0.9716 | 0.9589 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1389 | 0.6264 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.2172 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.2172 | 1 | 1 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0708 | 0.3019 | 0.3019 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1389 | 0.6264 | 0.8984 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1464 | 0.6622 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0724 | 0.3094 | 0.3094 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.2172 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.2172 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1404 | 0.6338 | 0.9571 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0075 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0724 | 0.3094 | 0.3094 |
Entamoeba histolytica | protein kinase, putative | 0.2172 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.1389 | 0.6264 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0724 | 0.3094 | 0.3094 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1389 | 0.6264 | 0.8984 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1464 | 0.6622 | 0.6622 |
Entamoeba histolytica | protein kinase, putative | 0.2113 | 0.9716 | 0.9716 |
Toxoplasma gondii | AGC kinase | 0.2113 | 0.9716 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1404 | 0.6338 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.025 uM | Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icilin induction measured after 5 mins by fluorescence assay | ChEMBL. | 23411075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.