Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0215 | 0.1002 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0593 | 0.0568 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.1002 | 0.0978 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.0142 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0142 | 0.0116 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0142 | 0.5 |
Brugia malayi | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | acetylcholinesterase | 0.1275 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0215 | 0.1002 | 0.0978 |
Loa Loa (eye worm) | carboxylesterase | 0.1275 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0215 | 0.1002 | 0.1002 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.1002 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.1275 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0215 | 0.1002 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0593 | 0.0568 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.0142 | 0.0116 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0169 | 0.0609 | 0.0583 |
Loa Loa (eye worm) | carboxylesterase | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | insulin receptor | 0.0101 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | neuroligin | 0.0215 | 0.1002 | 0.1002 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.0593 | 0.0568 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0215 | 0.1002 | 0.1002 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0215 | 0.1002 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0101 | 0.0027 | 0.0027 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0215 | 0.1002 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0215 | 0.1002 | 1 |
Schistosoma mansoni | gliotactin | 0.0215 | 0.1002 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1275 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.0142 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.1275 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0215 | 0.1002 | 0.0978 |
Echinococcus granulosus | acetylcholinesterase | 0.1275 | 1 | 1 |
Onchocerca volvulus | 0.0215 | 0.1002 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Onchocerca volvulus | 0.0215 | 0.1002 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.1002 | 0.0978 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.0142 | 0.0116 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0215 | 0.1002 | 0.0978 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1275 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0215 | 0.1002 | 0.0978 |
Brugia malayi | Carboxylesterase family protein | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0169 | 0.0609 | 0.0609 |
Brugia malayi | Carboxylesterase family protein | 0.1275 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0315 | 0.1845 | 0.1823 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0315 | 0.1845 | 0.1823 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.0142 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0215 | 0.1002 | 0.0978 |
Onchocerca volvulus | 0.0215 | 0.1002 | 1 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0315 | 0.1845 | 0.1845 |
Loa Loa (eye worm) | carboxylesterase | 0.0215 | 0.1002 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0215 | 0.1002 | 0.0978 |
Echinococcus multilocularis | acetylcholinesterase | 0.1275 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0215 | 0.1002 | 0.1002 |
Echinococcus granulosus | acetylcholinesterase | 0.1275 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0215 | 0.1002 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0215 | 0.1002 | 0.0978 |
Onchocerca volvulus | 0.0215 | 0.1002 | 1 | |
Echinococcus granulosus | neuroligin | 0.0215 | 0.1002 | 0.0978 |
Schistosoma mansoni | tyrosine kinase | 0.0169 | 0.0609 | 0.0583 |
Schistosoma mansoni | tyrosine kinase | 0.0169 | 0.0609 | 0.0583 |
Schistosoma mansoni | tyrosine kinase | 0.0315 | 0.1845 | 0.1823 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0315 | 0.1845 | 0.1823 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0215 | 0.1002 | 0.0978 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.0142 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1275 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1275 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.0142 | 0.0142 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.0142 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0169 | 0.0609 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.1002 | 0.0978 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0215 | 0.1002 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0142 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.6213 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.