TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 490.657 | Formula: C29H34N2O3S
H donors: 1 H acceptors: 3 LogP: 4.92 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H]1N2CCCCN(C[C@@H]2[C@@H]1c1ccc(cc1)c1cccc(c1)C)S(=O)(=O)c1cccc(c1)C
InChi: 1S/C29H34N2O3S/c1-21-7-5-9-25(17-21)23-11-13-24(14-12-23)29-27-19-30(15-3-4-16-31(27)28(29)20-32)35(33,34)26-10-6-8-22(2)18-26/h5-14,17-18,27-29,32H,3-4,15-16,19-20H2,1-2H3/t27-,28+,29+/m1/s1
InChiKey: CUGASRBZJHCBGN-ULNSLHSMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	paired box 8	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Brugia malayi	Pax transcription factor protein 2	Get druggable targets OG5_139945	All targets in OG5_139945
Onchocerca volvulus		Get druggable targets OG5_139945	All targets in OG5_139945

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0006	0.0039	0.0002
Onchocerca volvulus		0.001	0.0138	0.0142
Brugia malayi	mbt repeat family protein	0.0047	0.1076	0.1458
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.001	0.0138	0.0101
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0006	0.0039	0.0003
Loa Loa (eye worm)	STAT protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	acetylcholinesterase	0.0139	0.3361	0.3336
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0006	0.0039	0.0003
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0138	0.0101
Schistosoma mansoni	tensin	0.0006	0.0039	0.0039
Echinococcus multilocularis	neuroligin	0.0023	0.0483	0.0448
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1398	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0483	0.0483
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Echinococcus granulosus	growth factor receptor bound protein 2	0.0006	0.0039	0.0002
Echinococcus multilocularis	NCK adaptor protein	0.0006	0.0039	0.0002
Schistosoma mansoni	tensin-related	0.0006	0.0039	0.0039
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0081
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Trichomonas vaginalis	spcc417.12 protein, putative	0.0023	0.0483	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.001	0.0138	0.0101
Brugia malayi	Protein kinase domain containing protein	0.001	0.0138	0.0142
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	cpg binding protein	0.003	0.0648	0.0613
Echinococcus multilocularis		0.0006	0.0039	0.0002
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0006	0.0039	0.0002
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.1076	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.4541	0.452
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0138	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0006	0.0039	0.0002
Echinococcus granulosus	neuroligin	0.0023	0.0483	0.0448
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.1398	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1398	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1398	0.1398
Onchocerca volvulus		0.0006	0.0039	0.0003
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0023	0.0483	0.0483
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.4541	0.452
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0006	0.0039	0.0002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0483	0.0483
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.001	0.0138	0.0101
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0039	0.0002
Schistosoma mansoni	nck2/grb4	0.0006	0.0039	0.0039
Echinococcus granulosus	tyrosine protein kinase Src64B	0.001	0.0138	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0039	0.0039
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0115	0.0109
Schistosoma mansoni	cpg binding protein	0.003	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0006	0.0039	0.0002
Echinococcus granulosus	carboxylesterase 5A	0.0139	0.3361	0.3336
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.1239	0.1206
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0023	0.0483	0.0483
Echinococcus multilocularis	tyrosine protein kinase shark	0.001	0.0138	0.0101
Brugia malayi	mbt repeat family protein	0.0047	0.1076	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Onchocerca volvulus		0.001	0.0138	0.0142
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.1239	0.1206
Onchocerca volvulus		0.0006	0.0039	0.0003
Schistosoma mansoni	hypothetical protein	0.0286	0.706	0.706
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0006	0.0039	0.0002
Onchocerca volvulus		0.0006	0.0039	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Echinococcus multilocularis	SH2 motif	0.0006	0.0039	0.0002
Echinococcus granulosus	SH2 motif	0.0006	0.0039	0.0002
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0006	0.0039	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus granulosus	SH2 domain containing protein 7	0.0006	0.0039	0.0002
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Schistosoma mansoni	adapter molecule crk	0.0006	0.0039	0.0039
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.1239	0.1206
Schistosoma mansoni	cpg binding protein	0.0028	0.0608	0.0608
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Brugia malayi	Protein kinase domain containing protein	0.001	0.0138	0.0142
Brugia malayi	Carboxylesterase family protein	0.0023	0.0483	0.0626
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0074	0.0037
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0006	0.0039	0.0039
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0006	0.0039	0.0003
Echinococcus granulosus	N chimaerin	0.0006	0.0039	0.0002
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0006	0.0039	0.0039
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0006	0.0039	0.0003
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0006	0.0039	0.0002
Brugia malayi	Carboxylesterase family protein	0.0139	0.3361	0.4664
Onchocerca volvulus		0.0047	0.1076	0.1458
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	tyrosine protein kinase Srms	0.001	0.0138	0.0101
Echinococcus multilocularis	tyrosine protein kinase Blk	0.001	0.0138	0.0101
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.1239	0.1239
Schistosoma mansoni	BC026374 protein (S09 family)	0.0023	0.0483	0.0483
Echinococcus granulosus	BC026374 protein S09 family	0.0023	0.0483	0.0448
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0023	0.0483	1
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.1076	0.1043
Echinococcus granulosus	SHC transforming protein 3	0.0006	0.0039	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Schistosoma mansoni	signal transduction protein lnk-related	0.0006	0.0039	0.0039
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0023	0.0483	0.0448
Loa Loa (eye worm)	carboxylesterase	0.0139	0.3361	0.4664
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0074	0.0037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0138	0.0142
Schistosoma mansoni	shc transforming protein	0.0006	0.0039	0.0039
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0006	0.0039	0.0002
Onchocerca volvulus		0.0028	0.0608	0.08
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0039	0.0039
Brugia malayi	Carboxylesterase family protein	0.0023	0.0483	0.0626
Echinococcus granulosus	tyrosine kinase	0.001	0.0138	0.0101
Schistosoma mansoni	vav2	0.0006	0.0039	0.0039
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Loa Loa (eye worm)	acetylcholinesterase 1	0.0139	0.3361	0.4664
Brugia malayi	SH2 domain containing protein	0.001	0.0138	0.0142
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0006	0.0039	0.0003
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0074	0.0037
Brugia malayi	protein-tyrosine kinase	0.001	0.0138	0.0142
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Schistosoma mansoni	cpg binding protein	0.003	0.0648	0.0648
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Schistosoma mansoni	paired box protein pax-6	0.0006	0.0037	0.0037
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1076	0.1458
Echinococcus granulosus	tyrosine protein kinase shark	0.001	0.0138	0.0101
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0006	0.0039	0.0002
Schistosoma mansoni	GTPase activating protein	0.0006	0.0039	0.0039
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1403	0.1403
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0006	0.0039	0.0002
Schistosoma mansoni	suppressor of cytokine signaling	0.0006	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1239	0.1687
Brugia malayi	Protein kinase domain containing protein	0.001	0.0138	0.0142
Brugia malayi	hypothetical protein	0.0023	0.0483	0.0626
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0006	0.0039	0.0002
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0006	0.0039	0.0039
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.001	0.0138	0.0101
Schistosoma mansoni	tensin-related	0.0006	0.0039	0.0039
Echinococcus granulosus	SH2 motif	0.0006	0.0039	0.0002
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0138	0.0101
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0006	0.0039	0.0002
Echinococcus multilocularis	SH2 domain containing protein 7	0.0006	0.0039	0.0002
Echinococcus granulosus	acetylcholinesterase	0.0139	0.3361	0.3336
Loa Loa (eye worm)	TK protein kinase	0.001	0.0138	0.0142
Schistosoma mansoni	tensin	0.0006	0.0039	0.0039
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0006	0.0039	0.0002
Echinococcus granulosus	tensin	0.0006	0.0039	0.0002
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0006	0.0039	0.0039
Schistosoma mansoni	hypothetical protein	0.0404	1	1
Onchocerca volvulus		0.001	0.0138	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Brugia malayi	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus granulosus	cpg binding protein	0.003	0.0648	0.0613
Schistosoma mansoni	paired box protein pax-1-related	0.0006	0.0037	0.0037
Echinococcus multilocularis	SH2 motif	0.0006	0.0039	0.0002
Echinococcus multilocularis	signal transduction protein lnk realted	0.0006	0.0039	0.0002
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Echinococcus granulosus	signal transduction protein lnk realted	0.0006	0.0039	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0039	0.0003
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.1076	0.1043
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.1076	0.1043
Loa Loa (eye worm)	TK/ABL protein kinase	0.001	0.0138	0.0142
Onchocerca volvulus		0.0023	0.0483	0.0626
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.001	0.0138	0.0101
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.1398	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.1076	0.1076
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.1239	0.1206
Echinococcus granulosus	tyrosine protein kinase Src42A	0.001	0.0138	0.0101
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0006	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3361	0.4664
Brugia malayi	hypothetical protein	0.001	0.0138	0.0142
Onchocerca volvulus		0.0023	0.0483	0.0626
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.1076	0.1043
Schistosoma mansoni	tensin	0.0006	0.0039	0.0039
Schistosoma mansoni	acetylcholinesterase	0.0023	0.0483	0.0483
Echinococcus granulosus	tyrosine kinase	0.001	0.0138	0.0101
Schistosoma mansoni	hypothetical protein	0.0006	0.0039	0.0039
Brugia malayi	Pax transcription factor protein 2	0.0291	0.7163	1
Onchocerca volvulus		0.0023	0.0483	0.0626
Echinococcus granulosus	tyrosine protein kinase Srms	0.001	0.0138	0.0101
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0006	0.0039	0.0002
Loa Loa (eye worm)	MBCTL1	0.0054	0.1239	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Onchocerca volvulus		0.001	0.0138	0.0142
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0483	0.0626
Loa Loa (eye worm)	SRC-1	0.001	0.0138	0.0142
Echinococcus granulosus	tyrosine protein kinase Blk	0.001	0.0138	0.0101
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1398	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.1076	0.1458
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.1239	0.1687
Onchocerca volvulus		0.001	0.0138	0.0142
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0006	0.0039	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.1398	0.1366
Echinococcus granulosus	acetylcholinesterase	0.0139	0.3361	0.3336
Echinococcus multilocularis	tyrosine kinase	0.001	0.0138	0.0101
Onchocerca volvulus		0.001	0.0138	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0483	0.0626
Schistosoma mansoni	SH2A	0.0006	0.0039	0.0039
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0138	0.0101
Brugia malayi	Protein kinase domain containing protein	0.001	0.0138	0.0142
Echinococcus granulosus	hypothetical protein	0.0006	0.0039	0.0002
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.0138	0.0101
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0006	0.0039	0.0003
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0006	0.0039	0.0003
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.001	0.0138	0.0101
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.1076	0.1076
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0023	0.0483	0.0448
Onchocerca volvulus		0.0006	0.0039	0.0003
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0039	0.0003
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	tensin	0.0006	0.0039	0.0002
Schistosoma mansoni	gliotactin	0.0023	0.0483	0.0483
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0074	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.1398	1
Onchocerca volvulus		0.0023	0.0483	0.0626
Schistosoma mansoni	suppressor of cytokine signaling	0.0006	0.0039	0.0039
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0039	0.0003
Echinococcus granulosus	expressed conserved protein	0.0006	0.0039	0.0002
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.7163	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0118	0.0113
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0138	0.0101
Echinococcus granulosus	tyrosine protein kinase ABL1	0.001	0.0138	0.0101
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0006	0.0039	0.0003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0006	0.0039	0.0003
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	para nitrobenzyl esterase	0.0023	0.0483	0.0448
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.1076	0.1458
Schistosoma mansoni	paired box protein pax-6	0.0006	0.0037	0.0037
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.001	0.0138	1
Echinococcus multilocularis	SHC transforming protein 3	0.0006	0.0039	0.0002
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.001	0.0138	0.0101
Brugia malayi	SRC-1	0.001	0.0138	0.0142
Echinococcus multilocularis	acetylcholinesterase	0.0139	0.3361	0.3336
Echinococcus granulosus	NCK adaptor protein	0.0006	0.0039	0.0002
Brugia malayi	Tensin	0.0006	0.0039	0.0003
Echinococcus multilocularis	N chimaerin	0.0006	0.0039	0.0002
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0006	0.0039	0.0002
Onchocerca volvulus		0.0006	0.0039	0.0003
Echinococcus granulosus	para nitrobenzyl esterase	0.0023	0.0483	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3361	0.4664
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0608	0.08
Brugia malayi	SH2 domain containing protein	0.001	0.0138	0.0142
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Schistosoma mansoni	hypothetical protein	0.0006	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0138	0.0101
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.001	0.0138	0.0101
Echinococcus multilocularis	dnaJ subfamily B	0.0404	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.001	0.0138	0.0101
Brugia malayi	Carboxylesterase family protein	0.0023	0.0483	0.0626
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0039	0.0003
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.1398	0.1366
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0081
Brugia malayi	SH2 domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	tensin	0.0006	0.0039	0.0002
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.001	0.0138	0.0101
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Brugia malayi	Sex muscle abnormal protein 5	0.0006	0.0039	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Schistosoma mansoni	tyrosine kinase	0.001	0.0138	0.0138
Onchocerca volvulus		0.0006	0.0039	0.0003
Brugia malayi	RhoGAP domain containing protein	0.0006	0.0039	0.0003
Echinococcus multilocularis	SH2 motif	0.0006	0.0039	0.0002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0139	0.3361	0.3361
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0006	0.0039	0.0002
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1398	0.1398
Echinococcus multilocularis	carboxylesterase 5A	0.0139	0.3361	0.3336
Brugia malayi	Carboxylesterase family protein	0.0139	0.3361	0.4664
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0006	0.0039	0.0003
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0023	0.0483	0.0448
Loa Loa (eye worm)	carboxylesterase	0.0023	0.0483	0.0626
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0608	0.08
Loa Loa (eye worm)	SH2 domain-containing protein	0.0006	0.0039	0.0003
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.001	0.0138	0.0101
Onchocerca volvulus		0.0023	0.0483	0.0626
Brugia malayi	Protein kinase domain containing protein	0.001	0.0138	0.0142
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0138	0.0101
Brugia malayi	Carboxylesterase family protein	0.0023	0.0483	0.0626
Schistosoma mansoni	paired box protein pax-6	0.0006	0.0037	0.0037
Onchocerca volvulus		0.0291	0.7163	1
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0138	0.0142

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 7.45 uM	PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2357642

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1756240