Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2033 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2033 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2033 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2033 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2033 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2033 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2033 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2033 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2033 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2033 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2033 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2033 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2033 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2033 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2033 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0222 | 0.0222 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2033 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2033 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2033 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2033 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2033 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DD (functional) | = 4.89 | Deoxyribose degradaton (DD) as micromol of malondialdehyde/mmol of deoxyribose released by 75 uM | ChEMBL. | 8759634 |
IC50 (functional) | = 1.9 uM | Tested for antiproliferative activity against HaCaT cells | ChEMBL. | 8759634 |
IC50 (functional) | = 1.9 uM | Tested for antiproliferative activity against HaCaT cells | ChEMBL. | 8759634 |
IC50 (binding) | = 13 uM | Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL | ChEMBL. | 8759634 |
IC50 (binding) | = 13 uM | Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL | ChEMBL. | 8759634 |
IC50 (binding) | > 30 uM | Tested for inhibition of 12-LO (12-lipoxygenase) as an inhibitor of 12(S)-HETE biosynthesis in mouse epidermal homogenates | ChEMBL. | 8759634 |
IC50 (binding) | > 30 uM | Tested for inhibition of 12-LO (12-lipoxygenase) as an inhibitor of 12(S)-HETE biosynthesis in mouse epidermal homogenates | ChEMBL. | 8759634 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8759634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.