Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0027 | 0.0872 | 0.0872 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.3243 | 0.3243 |
Onchocerca volvulus | 0.0027 | 0.0872 | 0.5 | |
Schistosoma mansoni | lamin | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0872 | 0.0872 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0757 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0159 | 0.9524 | 0.9524 |
Echinococcus granulosus | lamin | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0872 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0063 | 0.3243 | 0.3243 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0757 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0872 | 0.0872 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0872 | 0.0872 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0872 | 0.0872 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3243 | 0.3243 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.3243 | 0.3243 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0872 | 0.0872 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0757 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0872 | 0.0872 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0175 | 0.0175 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3243 | 0.3243 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0757 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.3243 | 0.3243 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0757 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3243 | 0.3243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3243 | 0.3243 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0757 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0757 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0056 | 0.0056 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0757 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.3243 | 0.3243 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.3243 | 0.3243 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0757 | 0.0757 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0757 | 0.0757 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.3243 | 0.3243 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0872 | 0.0872 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0872 | 0.0872 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.084 | 0.084 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.3243 | 0.3243 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0167 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0167 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.3243 | 0.3243 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0167 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.52 10'4/M/min | Inhibition of electric eel AChE by concentration-dependent inhibition assay | ChEMBL. | 23453838 |
Ki (binding) | = 6.16 10'4/M/min | Inhibition of human recombinant AChE by concentration-dependent inhibition assay | ChEMBL. | 23453838 |
Ki (binding) | = 8.64 10'4/M/min | Inhibition of electric eel AChE by time-dependent inhibition assay | ChEMBL. | 23453838 |
Ki (binding) | = 1.02 10'5/M/min | Inhibition of human recombinant AChE by time-dependent inhibition assay | ChEMBL. | 23453838 |
Ki (binding) | = 1.16 10'6/M/min | Inhibition of rat brain AChE by concentration-dependent inhibition assay | ChEMBL. | 23453838 |
Ki (binding) | = 3.77 10'6/M/min | Inhibition of rat brain AChE by time-dependent inhibition assay | ChEMBL. | 23453838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.