TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 477.64 | Formula: C23H31N3O4S2
H donors: 1 H acceptors: 5 LogP: 4.39 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](n1c(C)cc(cc1=O)S(=O)(=O)C1CCCC1)CC1CCCCC1)Nc1nccs1
InChi: 1S/C23H31N3O4S2/c1-16-13-19(32(29,30)18-9-5-6-10-18)15-21(27)26(16)20(14-17-7-3-2-4-8-17)22(28)25-23-24-11-12-31-23/h11-13,15,17-18,20H,2-10,14H2,1H3,(H,24,25,28)/t20-/m0/s1
InChiKey: WADVHYJTRIDKDF-FQEVSTJZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucokinase (hexokinase 4)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	hexokinase 2	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania braziliensis	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium vivax	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium knowlesi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium parvum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	Hexokinase family protein	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium yoelii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Treponema pallidum	hexokinase (hxk)	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma mansoni	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Toxoplasma gondii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium falciparum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase type II	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania donovani	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 1	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma japonicum	ko:K00844 hexokinase [EC2.7.1.1], putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium berghei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium hominis	hexokinase i	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Babesia bovis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Neospora caninum	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma congolense	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hexokinase family protein	glucokinase (hexokinase 4)	465 aa	470 aa	30.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	carboxylesterase, LipT	0.1013	0.1673	1
Brugia malayi	Pre-SET motif family protein	0.023	0.0364	0.0364
Entamoeba histolytica	hexokinase 1	0.0096	0.0141	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1013	0.1673	1
Echinococcus multilocularis	choline O acetyltransferase	0.0181	0.0283	0.0283
Entamoeba histolytica	hexokinase 2	0.0096	0.0141	1
Loa Loa (eye worm)	hexokinase	0.0096	0.0141	0.0141
Trypanosoma cruzi	hexokinase, putative	0.0096	0.0141	0.1822
Brugia malayi	hexokinase	0.0096	0.0141	0.0141
Loa Loa (eye worm)	carboxylesterase	0.5995	1	1
Brugia malayi	hypothetical protein	0.0019	0.0012	0.0012
Echinococcus granulosus	acetylcholinesterase	0.5995	1	1
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Brugia malayi	Carboxylesterase family protein	0.1013	0.1673	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0046	0.0046
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0044	0.019
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0046	0.0057	0.0505
Echinococcus granulosus	BC026374 protein S09 family	0.1013	0.1673	0.1673
Plasmodium falciparum	hexokinase	0.0096	0.0141	1
Loa Loa (eye worm)	hypothetical protein	0.5995	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0055	0.0055
Onchocerca volvulus		0.0027	0.0025	0.0079
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0027	0.0025	0.0025
Brugia malayi	Hexokinase family protein	0.0096	0.0141	0.0141
Trypanosoma brucei	hexokinase	0.0096	0.0141	0.1822
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0057	0.351
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0055	0.0055
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0019	0.0012	0.0012
Onchocerca volvulus		0.0096	0.0141	0.0775
Brugia malayi	amine oxidase, flavin-containing family protein	0.0046	0.0057	0.0057
Schistosoma mansoni	choline o-acyltransferase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hexokinase	0.0096	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0031	0.0031
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.0417	0.2439
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0035	0.1795
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0046	0.0057	0.0057
Mycobacterium tuberculosis	Carboxylesterase LipT	0.1013	0.1673	1
Treponema pallidum	hexokinase (hxk)	0.0096	0.0141	0.5
Echinococcus multilocularis	hexokinase	0.0096	0.0141	0.0141
Echinococcus multilocularis	para nitrobenzyl esterase	0.1013	0.1673	0.1673
Schistosoma mansoni	amine oxidase	0.0046	0.0057	0.0057
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0046	0.0057	0.0057
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0407	0.066	1
Brugia malayi	Hexokinase family protein	0.003	0.003	0.003
Brugia malayi	hypothetical protein	0.0019	0.0012	0.0012
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0656	0.1076	0.6305
Onchocerca volvulus		0.0096	0.0141	0.0775
Echinococcus multilocularis	hexokinase	0.0096	0.0141	0.0141
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0046	0.0046
Trichomonas vaginalis	spcc417.12 protein, putative	0.1013	0.1673	1
Echinococcus granulosus	acetylcholinesterase	0.5995	1	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.061	0.0999	0.5828
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0035	0.0035
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0019	0.0012	0.0012
Onchocerca volvulus		0.1013	0.1673	1
Loa Loa (eye worm)	hexokinase type II	0.0096	0.0141	0.0141
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Echinococcus multilocularis	acetylcholinesterase	0.5995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0407	0.066	0.066
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0057	0.351
Trypanosoma brucei	hexokinase	0.0096	0.0141	0.1822
Loa Loa (eye worm)	carboxylesterase	0.1013	0.1673	0.1673
Onchocerca volvulus		0.0027	0.0025	0.0079
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0027	0.0025	0.0025
Brugia malayi	aspartic protease BmAsp-1, identical	0.0019	0.0012	0.0012
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0046	0.0057	0.0057
Onchocerca volvulus		0.1013	0.1673	1
Loa Loa (eye worm)	hypothetical protein	0.0208	0.0328	0.0328
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.0048	0.0048
Onchocerca volvulus		0.0096	0.0141	0.0775
Toxoplasma gondii	hexokinase	0.0096	0.0141	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0035	0.0035
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0019	0.0012	0.0012
Brugia malayi	Carboxylesterase family protein	0.1013	0.1673	0.1673
Schistosoma mansoni	neuroligin 3 (S09 family)	0.1013	0.1673	0.1673
Schistosoma mansoni	acetylcholinesterase	0.1013	0.1673	0.1673
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0035	0.0035
Brugia malayi	aspartic protease BmAsp-2, identical	0.0019	0.0012	0.0012
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Echinococcus multilocularis		0.0046	0.0057	0.0057
Brugia malayi	Carboxylesterase family protein	0.1013	0.1673	0.1673
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0046	0.0046
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1013	0.1673	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Loa Loa (eye worm)	aspartyl protease 6	0.0019	0.0012	0.0012
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0046	0.0057	0.351
Onchocerca volvulus		0.006	0.0081	0.0415
Schistosoma mansoni	BC026374 protein (S09 family)	0.1013	0.1673	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Leishmania major	hexokinase, putative	0.0096	0.0141	0.1822
Echinococcus granulosus	hexokinase	0.0096	0.0141	0.0141
Loa Loa (eye worm)	acetylcholinesterase 1	0.5995	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0025
Echinococcus granulosus	choline O acetyltransferase	0.0181	0.0283	0.0283
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Onchocerca volvulus		0.1013	0.1673	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0407	0.066	0.066
Onchocerca volvulus		0.0027	0.0025	0.0079
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1013	0.1673	0.1673
Trypanosoma brucei	hexokinase, putative	0.0096	0.0141	0.1822
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0027	0.0025	0.0025
Schistosoma mansoni	choline o-acyltransferase	0.0181	0.0283	0.0283
Echinococcus granulosus	hexokinase	0.0096	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Loa Loa (eye worm)	hexokinase	0.003	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Brugia malayi	hexokinase type II	0.0031	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.0048	0.0048
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0046	0.0057	0.0057
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0407	0.066	1
Brugia malayi	Choline O-acetyltransferase	0.0181	0.0283	0.0283
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0019	0.0012	0.0012
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.0364	0.0364
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0046	0.0057	0.0057
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0046	0.0057	0.0057
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0046	0.0057	0.351
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0012	0.0012
Loa Loa (eye worm)	carboxylesterase	0.1013	0.1673	0.1673
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0035	0.0035
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0057	0.351
Echinococcus granulosus	para nitrobenzyl esterase	0.1013	0.1673	0.1673
Onchocerca volvulus		0.1013	0.1673	1
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Brugia malayi	Hexokinase family protein	0.006	0.0081	0.0081
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Brugia malayi	SWIRM domain containing protein	0.0046	0.0057	0.0057
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0046	0.0057	0.0505
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0046	0.0057	0.5
Toxoplasma gondii	histone lysine-specific demethylase	0.0046	0.0057	0.351
Onchocerca volvulus	Hexokinase homolog	0.006	0.0081	0.0415
Onchocerca volvulus		0.1013	0.1673	1
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0027	0.0025	0.0025
Echinococcus multilocularis	BC026374 protein (S09 family)	0.1013	0.1673	0.1673
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0046	0.0057	0.351
Echinococcus multilocularis	carboxylesterase 5A	0.5995	1	1
Brugia malayi	Pepsin A precursor	0.0019	0.0012	0.0012
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0046	0.0057	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1013	0.1673	0.1673
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.5995	1	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0035	0.0035
Loa Loa (eye worm)	hexokinase	0.006	0.0081	0.0081
Leishmania major	hexokinase, putative	0.0096	0.0141	0.1822
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0012	0.0012
Echinococcus granulosus	neuroligin	0.1013	0.1673	0.1673
Schistosoma mansoni	gliotactin	0.1013	0.1673	0.1673
Onchocerca volvulus		0.0033	0.0035	0.0139
Brugia malayi	hypothetical protein	0.1013	0.1673	0.1673
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0656	0.1076	0.6305
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0019	0.0012	0.0012
Brugia malayi	Choline O-acetyltransferase	0.0181	0.0283	0.0283
Echinococcus granulosus	carboxylesterase 5A	0.5995	1	1
Echinococcus granulosus	hexokinase	0.0096	0.0141	0.0141
Leishmania major	UDP-galactopyranose mutase	0.0046	0.0057	0.0505
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Onchocerca volvulus		0.0027	0.0025	0.0079
Brugia malayi	hypothetical protein	0.0039	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0035	0.0035
Echinococcus multilocularis	hexokinase type 2	0.0096	0.0141	0.0141
Schistosoma mansoni	hexokinase	0.0096	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.1013	0.1673	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.0039	0.0046	0.0046
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Plasmodium vivax	hexokinase, putative	0.0096	0.0141	1
Schistosoma mansoni	hypothetical protein	0.0057	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.5995	1	1
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.1013	0.1673	0.1673
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0012	0.0012
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1013	0.1673	0.1673
Plasmodium vivax	SET domain protein, putative	0.0033	0.0035	0.1795
Brugia malayi	Carboxylesterase family protein	0.5995	1	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0046	0.0057	0.0057
Echinococcus multilocularis	neuroligin	0.1013	0.1673	0.1673
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0046	0.0057	0.351
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0057	0.0057
Schistosoma mansoni	amine oxidase	0.0046	0.0057	0.0057
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.0048	0.0048
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.1013	0.1673	0.1673
Echinococcus multilocularis	hexokinase	0.0096	0.0141	0.0141
Onchocerca volvulus		0.0262	0.0417	0.2439
Echinococcus granulosus	hexokinase type 2	0.0096	0.0141	0.0141
Leishmania major	C-8 sterol isomerase-like protein	0.0407	0.066	1
Onchocerca volvulus		0.0046	0.0057	0.0272
Loa Loa (eye worm)	hypothetical protein	0.1013	0.1673	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0035	0.0035
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.0027	0.0025	0.0025
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0035	0.0035
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.0027	0.0025	0.0025
Brugia malayi	Carboxylesterase family protein	0.1013	0.1673	0.1673
Echinococcus multilocularis	carnitine O palmitoyltransferase 2	0.0027	0.0025	0.0025
Loa Loa (eye worm)	choline O-acetyltransferase	0.0181	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0031	0.0031
Plasmodium falciparum	protoporphyrinogen oxidase	0.0046	0.0057	0.351
Echinococcus multilocularis	acetylcholinesterase	0.5995	1	1
Echinococcus granulosus	carnitine O palmitoyltransferase 2	0.0027	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0066	0.009	0.009
Trypanosoma cruzi	hexokinase, putative	0.0096	0.0141	0.1822
Schistosoma mansoni	memapsin-2 (A01 family)	0.0476	0.0776	0.0776

Activities

Activity type	Activity value	Assay description	Source	Reference
%max (binding)	= 88 %	Activation of glucokinase (unknown origin) relative to control	ChEMBL.	23434031
EC50 (binding)	= 0.079 uM	Activation of glucokinase (unknown origin)	ChEMBL.	23434031

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2346761

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1756393