TDR Targets

Basic information

Technical information

TDR Targets ID: 1756664
Name: N-(2,4-difluorophenyl)-2,7-dimethyl-5-oxo-[1, 3]thiazolo[3,2-a]pyrimidine-6-sulfonamide
MW: 371.382 | Formula: C14H11F2N3O3S2
H donors: 1 H acceptors: 3 LogP: 1.86 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)NS(=O)(=O)c1c(C)nc2n(c1=O)cc(s2)C
InChi: 1S/C14H11F2N3O3S2/c1-7-6-19-13(20)12(8(2)17-14(19)23-7)24(21,22)18-11-4-3-9(15)5-10(11)16/h3-6,18H,1-2H3
InChiKey: BOENIPXDIWDMHQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-difluorophenyl)-2,7-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidine-6-sulfonamide
N-(2,4-difluorophenyl)-2,7-dimethyl-5-oxo-6-thiazolo[3,2-a]pyrimidinesulfonamide
N-(2,4-difluorophenyl)-5-keto-2,7-dimethyl-thiazolo[3,2-a]pyrimidine-6-sulfonamide
E559-0728
NCGC00122967-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	kinase suppressor of Ras 1	0.004	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine kinase	0.004	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Plasmodium falciparum	protein kinase, putative	0.004	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Echinococcus multilocularis	protein kinase	0.004	1	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.004	1	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	1	1
Brugia malayi	SH2 domain containing protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.004	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Echinococcus multilocularis	heat shock protein 70	0.004	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.004	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Schistosoma mansoni	hypothetical protein	0.0037	0.8019	0.8019
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Brugia malayi	hypothetical protein	0.004	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.004	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.004	1	1
Brugia malayi	C-terminal src kinase protein 1	0.004	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	hypothetical protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Giardia lamblia	Kinase	0.004	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.004	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.004	1	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Echinococcus multilocularis	activin receptor type	0.004	1	1
Plasmodium falciparum	protein kinase, putative	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.004	1	1
Leishmania major	protein kinase, putative	0.004	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.004	1	1
Entamoeba histolytica	ankyrin repeat protein	0.004	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Giardia lamblia	Kinase, NEK	0.004	1	1
Trichomonas vaginalis	STE family protein kinase	0.004	1	1
Trichomonas vaginalis	AGC family protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	1	1
Schistosoma mansoni	protein tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Toxoplasma gondii	STE kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Plasmodium vivax	protein kinase, putative	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.004	1	1
Echinococcus multilocularis	protein tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.8019	0.8019
Entamoeba histolytica	tyrosin kinase, putative	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.004	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.004	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.004	1	0.5
Onchocerca volvulus		0.004	1	0.5
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Trypanosoma cruzi	protein kinase, putative	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Entamoeba histolytica	hypothetical protein	0.0037	0.8019	0.8019
Entamoeba histolytica	hypothetical protein	0.004	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.004	1	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.004	1	1
Entamoeba histolytica	ankyrin repeat protein	0.004	1	1
Echinococcus multilocularis	protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Schistosoma mansoni	protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Trypanosoma brucei	Pseudokinase, putative	0.004	1	1
Echinococcus granulosus	tyrosine kinase	0.004	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.004	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.8019	0.8019
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Loa Loa (eye worm)	SRC-1	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.004	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.004	1	1
Schistosoma mansoni	hypothetical protein	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.8019	0.8019
Echinococcus multilocularis	insulin receptor	0.004	1	1
Giardia lamblia	Kinase, NEK	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	SH2 domain containing protein	0.004	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Echinococcus granulosus	activated cdc42 kinase 1	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.004	1	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.004	1	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	cysteine surface protein, putative	0.004	1	1
Echinococcus granulosus	protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.004	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.004	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.8019	0.8019
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.004	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine kinase	0.004	1	1
Leishmania major	protein kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Schistosoma mansoni	ephrin receptor	0.004	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.004	1	1
Echinococcus multilocularis	FL cytokine receptor	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.8019	0.8019
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.004	1	1
Brugia malayi	protein-tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Echinococcus granulosus	integrin linked protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	1	1
Echinococcus granulosus	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Brugia malayi	integrin-linked kinase	0.004	1	1
Echinococcus multilocularis	transfer RNA-Thr	0.004	1	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.004	1	1
Brugia malayi	hypothetical protein	0.0037	0.8019	0.8019
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.004	1	1
Echinococcus granulosus	activin receptor type	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	serine/threonine RGC	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus granulosus	protein tyrosine kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	1	1
Trypanosoma cruzi	protein kinase, putative	0.004	1	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.004	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.004	1	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.004	1	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Echinococcus granulosus	insulin receptor	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Plasmodium falciparum	protein kinase, putative	0.004	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Echinococcus multilocularis	integrin linked protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.004	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.004	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.004	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.004	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.004	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.004	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.8019	0.8019
Loa Loa (eye worm)	TK/ROR protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.004	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.004	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.004	1	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.004	1	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.004	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.004	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.004	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Schistosoma mansoni	ephrin receptor	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.004	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Loa Loa (eye worm)	TK protein kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK/Met protein kinase	0.004	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.004	1	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.004	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.004	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Giardia lamblia	Protein 21.1	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.004	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.004	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	SRC-1	0.004	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.004	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.004	1	1
Echinococcus granulosus	c src tyrosine kinase	0.004	1	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.004	1	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.004	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.004	1	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Brugia malayi	ephrin receptor 1 precursor	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Schistosoma mansoni	tyrosine kinase	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	hypothetical protein	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	protein kinase, putative	0.004	1	1
Echinococcus granulosus	tyrosine kinase	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	hypothetical protein	0.004	1	1
Trypanosoma brucei	protein kinase, putative	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Brugia malayi	Protein kinase domain containing protein	0.004	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.004	1	1
Schistosoma mansoni	protein kinase	0.004	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.004	1	1
Trichomonas vaginalis	TK family protein kinase	0.004	1	1
Leishmania major	hypothetical protein, conserved	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.004	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.004	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Trichomonas vaginalis	TKL family protein kinase	0.004	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	1	1
Onchocerca volvulus		0.004	1	0.5
Brugia malayi	Raf kinase	0.004	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.004	1	1
Toxoplasma gondii	protein kinase	0.004	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.004	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2357665

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1756664