Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0069 | 0.1171 | 0.1037 |
Echinococcus granulosus | acetylcholinesterase | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0149 | 0.0149 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0069 | 0.1171 | 0.1171 |
Echinococcus granulosus | neuroligin | 0.0069 | 0.1171 | 0.1037 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0409 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.1171 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Echinococcus multilocularis | neuroligin | 0.0069 | 0.1171 | 0.1037 |
Echinococcus multilocularis | acetylcholinesterase | 0.0409 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0069 | 0.1171 | 0.1037 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0069 | 0.1171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0069 | 0.1171 | 0.1171 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0069 | 0.1171 | 0.1037 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0069 | 0.1171 | 0.1037 |
Echinococcus granulosus | acetylcholinesterase | 0.0409 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0069 | 0.1171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1171 | 0.1171 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0069 | 0.1171 | 0.1037 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0069 | 0.1171 | 0.1037 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0069 | 0.1171 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.1171 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.1171 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0409 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0069 | 0.1171 | 0.1171 |
Schistosoma mansoni | acetylcholinesterase | 0.0069 | 0.1171 | 0.1171 |
Onchocerca volvulus | 0.0069 | 0.1171 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1171 | 0.1037 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1171 | 0.1037 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1171 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1171 | 0.1171 |
Echinococcus multilocularis | acetylcholinesterase | 0.0409 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0409 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0.1171 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0409 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1171 | 0.1037 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.4571 | 0.4571 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.1171 | 0.1171 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.1171 | 0.1171 |
Onchocerca volvulus | 0.0069 | 0.1171 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0069 | 0.1171 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1171 | 0.1037 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.1171 | 0.1037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2 uM | Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | ChEMBL. | 23465611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.