Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Corticotropin releasing factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Pseudouridine-5 prime-monophosphatase homolog | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 27.2 % |
Loa Loa (eye worm) | hypothetical protein | Corticotropin releasing factor receptor 1 | 415 aa | 359 aa | 21.4 % |
Onchocerca volvulus | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 30.2 % | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | Corticotropin releasing factor receptor 1 | 415 aa | 394 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0235 | 0.9311 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0235 | 0.9311 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0235 | 0.9311 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0235 | 0.9311 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0235 | 0.9311 | 0.9311 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0235 | 0.9311 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0145 | 0.3543 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0116 | 0.1714 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.9311 | 0.9311 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0116 | 0.1714 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0118 | 0.1829 | 0.0151 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0145 | 0.3543 | 0.3543 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0235 | 0.9311 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0235 | 0.9311 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0235 | 0.9311 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0235 | 0.9311 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0235 | 0.9311 | 0.9311 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0208 | 0.7596 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0235 | 0.9311 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0235 | 0.9311 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0208 | 0.7596 | 0.8159 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0208 | 0.7596 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0145 | 0.3543 | 0.3543 |
Leishmania major | p450 reductase, putative | 0.0235 | 0.9311 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0235 | 0.9311 | 1 |
Brugia malayi | flavodoxin family protein | 0.0235 | 0.9311 | 0.9311 |
Entamoeba histolytica | type A flavoprotein, putative | 0.009 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0235 | 0.9311 | 0.5 |
Treponema pallidum | flavodoxin | 0.009 | 0 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0235 | 0.9311 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0235 | 0.9311 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0145 | 0.3543 | 0.2407 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0208 | 0.7596 | 0.8159 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0235 | 0.9311 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7356 | 0.661 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0235 | 0.9311 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0235 | 0.9311 | 1 |
Giardia lamblia | Hypothetical protein | 0.0208 | 0.7596 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.7356 | 0.661 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.4 nM | Displacement of [125I]-o-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting | ChEMBL. | 23465610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.