TDR Targets

Basic information

Technical information

TDR Targets ID: 1757730
Name: 1-[3,3-di(phenyl)propyl]-3-[3-(methoxymethyl) phenyl]-1-(2-morpholin-4-ylethyl)urea
MW: 487.633 | Formula: C30H37N3O3
H donors: 1 H acceptors: 1 LogP: 4.19 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: COCc1cccc(c1)NC(=O)N(CCC(c1ccccc1)c1ccccc1)CCN1CCOCC1
InChi: 1S/C30H37N3O3/c1-35-24-25-9-8-14-28(23-25)31-30(34)33(18-17-32-19-21-36-22-20-32)16-15-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27/h2-14,23,29H,15-22,24H2,1H3,(H,31,34)
InChiKey: NTRPWXGTTLFZCO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[3,3-di(phenyl)propyl]-3-[3-(methoxymethyl)phenyl]-1-(2-morpholinoethyl)urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium-sensing receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127276	All targets in OG5_127276
Schistosoma japonicum	Metabotropic glutamate receptor 7 precursor, putative	Get druggable targets OG5_127276	All targets in OG5_127276
Schistosoma japonicum	Metabotropic glutamate receptor 7 precursor, putative	Get druggable targets OG5_127276	All targets in OG5_127276

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	PH domain containing protein, putative	0.0424	0.0204	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Leishmania major	hypothetical protein, conserved	0.0424	0.0204	0.7379
Leishmania major	protein kinase, putative	0.0535	0.0276	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0535	0.0276	0.0429
Plasmodium falciparum	PH domain-containing protein, putative	0.0424	0.0204	0.0317
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0424	0.0204	0.021
Echinococcus granulosus	DCC interacting protein 13 beta	0.0424	0.0204	0.0304
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0424	0.0204	0.0304
Entamoeba histolytica	protein kinase, putative	1.547	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	Variant SH3 domain containing protein	0.0424	0.0204	0.0204
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0424	0.0204	0.0304
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0111	0	0.5
Echinococcus granulosus	serine/threonine protein kinase	1.0425	0.6715	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Toxoplasma gondii	hypothetical protein	0.0424	0.0204	0.021
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0535	0.0276	1
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Entamoeba histolytica	protein kinase 2, putative	1.0001	0.6439	0.6439
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0535	0.0276	1
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0111	0	0.5
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0111	0	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0424	0.0204	0.0317
Echinococcus multilocularis	rac serine:threonine kinase	1.0425	0.6715	1
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0424	0.0204	0.0304
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0424	0.0204	0.0304
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0424	0.0204	0.0317
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0535	0.0276	0.0276
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Onchocerca volvulus	Protein melted homolog	0.0424	0.0204	1
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Leishmania major	folate/biopterin transporter, putative	0.0535	0.0276	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0424	0.0204	0.0317
Schistosoma mansoni	centaurin alpha	0.0424	0.0204	0.0304
Loa Loa (eye worm)	hypothetical protein	0.5156	0.3285	0.3285
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0111	0	0.5
Entamoeba histolytica	protein kinase, putative	0.5156	0.3285	0.3285
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0424	0.0204	0.0204
Echinococcus multilocularis	Oxysterol binding protein 11	0.0424	0.0204	0.0304
Schistosoma mansoni	goodpasture antigen-binding protein	0.0424	0.0204	0.0304
Echinococcus multilocularis	pdz domain containing protein	0.0424	0.0204	0.0304
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	cytohesin 3	0.0424	0.0204	0.0204
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	1.0001	0.6439	0.9589
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0111	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0535	0.0276	0.0276
Echinococcus multilocularis	nervana 2	0.989	0.6367	0.9481
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	PH domain containing protein, putative	0.0424	0.0204	0.0304
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0424	0.0204	1
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0111	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0111	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	AGC/NDR protein kinase	0.5156	0.3285	0.3285
Echinococcus multilocularis	oxysterol binding protein 1	0.0424	0.0204	0.0304
Schistosoma mansoni	zinc finger protein	0.0424	0.0204	0.0304
Onchocerca volvulus	Putative zinc finger protein	0.0424	0.0204	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0424	0.0204	0.0304
Leishmania major	protein kinase, putative	0.0535	0.0276	1
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0424	0.0204	0.0204
Echinococcus multilocularis	Glutaredoxin protein 5	0.989	0.6367	0.9481
Toxoplasma gondii	protein kinase domain-containing protein	0.0535	0.0276	0.0284
Echinococcus granulosus	Glutaredoxin protein 5	0.989	0.6367	0.9481
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0424	0.0204	0.0304
Echinococcus multilocularis	cytohesin 1	0.0424	0.0204	0.0304
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.5156	0.3285	0.4891
Echinococcus granulosus	Pleckstrin y	0.0424	0.0204	0.0304
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0424	0.0204	0.0317
Trichomonas vaginalis	protein transport protein sec7, putative	0.0424	0.0204	0.0204
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0535	0.0276	0.0284
Plasmodium vivax	PH domain containing protein	0.0424	0.0204	0.0317
Schistosoma mansoni	serine/threonine kinase	0.5156	0.3285	0.4891
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.5156	0.3285	0.3285
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0424	0.0204	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	1.0001	0.6439	0.9589
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0535	0.0276	0.0411
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0535	0.0276	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0424	0.0204	0.0204
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0424	0.0204	0.0304
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	centaurin/arf, putative	0.0424	0.0204	0.0204
Plasmodium vivax	hypothetical protein, conserved	0.0424	0.0204	0.0317
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0424	0.0204	0.0304
Trypanosoma cruzi	Protein kinase B	1.0425	0.6715	1
Onchocerca volvulus		0.0424	0.0204	1
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0111	0	0.5
Onchocerca volvulus		0.0424	0.0204	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.5156	0.3285	0.4891
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	1.0001	0.6439	1
Loa Loa (eye worm)	AGC/AKT protein kinase	1.547	1	1
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0424	0.0204	0.0304
Toxoplasma gondii	AGC kinase	1.5046	0.9724	1
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0111	0	0.5
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Loa Loa (eye worm)	syntrophin-1	0.0424	0.0204	0.0204
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0535	0.0276	0.0411
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.5156	0.3285	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	Oxysterol-binding protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.558	0.3561	0.3561
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0535	0.0276	0.0411
Schistosoma mansoni	hypothetical protein	0.0424	0.0204	0.0304
Trypanosoma cruzi	PH domain containing protein, putative	0.0424	0.0204	0.0304
Entamoeba histolytica	hypothetical protein	0.0535	0.0276	0.0276
Echinococcus multilocularis	nervana 2	0.989	0.6367	0.9481
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0111	0	0.5
Onchocerca volvulus		0.0424	0.0204	1
Echinococcus multilocularis	actin binding protein anillin	0.0424	0.0204	0.0304
Echinococcus granulosus	Rho GTPase activating protein 24	0.0424	0.0204	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	Variant SH3 domain containing protein	0.0424	0.0204	0.0204
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0424	0.0204	0.0304
Echinococcus granulosus	beta 1 syntrophin	0.0424	0.0204	0.0304
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0424	0.0204	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Onchocerca volvulus		0.0424	0.0204	1
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0424	0.0204	0.0304
Echinococcus granulosus	Oxysterol binding protein 11	0.0424	0.0204	0.0304
Brugia malayi	Syntrophin-1	0.0424	0.0204	0.0204
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Brugia malayi	Protein kinase domain containing protein	0.5156	0.3285	0.3285
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Echinococcus granulosus	oxysterol binding protein 3	0.0424	0.0204	0.0304
Echinococcus granulosus	oxysterol binding protein 9	0.0424	0.0204	0.0304
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0111	0	0.5
Trypanosoma cruzi	NIMA-related kinase, putative	0.0535	0.0276	0.0411
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	1.0001	0.6439	1
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Chlamydia trachomatis	serine/threonine protein kinase	0.0111	0	0.5
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0424	0.0204	0.0204
Echinococcus granulosus	protein kinase c iota type	0.5156	0.3285	0.4891
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Toxoplasma gondii	hypothetical protein	0.0424	0.0204	0.021
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.5045	0.3212	0.3212
Entamoeba histolytica	hypothetical protein	0.0535	0.0276	0.0276
Schistosoma mansoni	hypothetical protein	0.0424	0.0204	0.0304
Schistosoma mansoni	syntrophin	0.0424	0.0204	0.0304
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Trichomonas vaginalis	AGC family protein kinase	0.5156	0.3285	0.3285
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Echinococcus multilocularis	oxysterol binding protein 3	0.0424	0.0204	0.0304
Echinococcus granulosus	cytohesin 1	0.0424	0.0204	0.0304
Trypanosoma brucei	protein kinase, putative	0.0535	0.0276	0.0276
Brugia malayi	Cadps2 protein	0.0424	0.0204	0.0204
Brugia malayi	Protein kinase domain containing protein	0.5156	0.3285	0.3285
Entamoeba histolytica	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0111	0	0.5
Trichomonas vaginalis	hypothetical protein	0.0424	0.0204	0.0204
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0111	0	0.5
Echinococcus granulosus	serine:threonine protein kinase N2	0.5156	0.3285	0.4891
Loa Loa (eye worm)	Plekhf2 protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0424	0.0204	0.0317
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0424	0.0204	1
Schistosoma mansoni	myotubularin-related protein	0.0424	0.0204	0.0304
Echinococcus granulosus	serine threonine protein kinase nrc	1.0001	0.6439	0.9589
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0424	0.0204	0.0204
Echinococcus multilocularis	protein kinase c epsilon type	0.5156	0.3285	0.4891
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0424	0.0204	0.0304
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Toxoplasma gondii	Oxysterol-binding protein	0.0424	0.0204	0.021
Trichomonas vaginalis	centaurin/arf, putative	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	AGC/PKN protein kinase	0.5156	0.3285	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.0424	0.0204	0.0304
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0424	0.0204	0.0204
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0424	0.0204	0.0304
Echinococcus multilocularis	oxysterol binding protein 9	0.0424	0.0204	0.0304
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0535	0.0276	0.0276
Onchocerca volvulus		0.0424	0.0204	1
Entamoeba histolytica	protein kinase, putative	1.5046	0.9724	0.9724
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0535	0.0276	0.0411
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0111	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0111	0	0.5
Schistosoma mansoni	goodpasture antigen-binding protein	0.0424	0.0204	0.0304
Schistosoma mansoni	dynamin	0.0424	0.0204	0.0304
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.5156	0.3285	0.3285
Schistosoma mansoni	serine/threonine-protein kinase	1.0425	0.6715	1
Entamoeba histolytica	protein kinase, putative	1.547	1	1
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0111	0	0.5
Echinococcus granulosus	Pleckstrin y	0.0424	0.0204	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	Hr1 repeat family protein	0.5156	0.3285	0.3285
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Onchocerca volvulus	outspread protein homolog	0.0424	0.0204	1
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.5156	0.3285	0.4891
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Entamoeba histolytica	protein kinase, putative	0.0535	0.0276	0.0276
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0424	0.0204	0.0304
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0111	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0535	0.0276	0.0276
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0535	0.0276	0.0276
Brugia malayi	hypothetical protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0424	0.0204	0.0304
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0424	0.0204	0.0204
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.989	0.6367	0.9481
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0424	0.0204	0.0304
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Echinococcus granulosus	nervana 2	0.989	0.6367	0.9481
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0424	0.0204	0.0204
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.0424	0.0204	0.0304
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0424	0.0204	0.0204
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0424	0.0204	0.0304
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0424	0.0204	0.0304
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0424	0.0204	0.0304
Trypanosoma cruzi	NIMA-related kinase, putative	0.0535	0.0276	0.0411
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0424	0.0204	0.0304
Leishmania major	serine/threonine-protein kinase a, putative	0.0535	0.0276	1
Echinococcus granulosus	pleckstrin y domain containing family A	0.0424	0.0204	0.0304
Loa Loa (eye worm)	rho-GTPase-activating	0.0424	0.0204	0.0204
Brugia malayi	protein kinase C II.	0.5156	0.3285	0.3285
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Schistosoma mansoni	atypical protein kinase C	0.5156	0.3285	0.4891
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Entamoeba histolytica	protein kinase, putative	0.0535	0.0276	0.0276
Echinococcus multilocularis	myotubularin protein 13	0.0424	0.0204	0.0304
Leishmania major	hypothetical protein, conserved	0.0424	0.0204	0.7379
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0424	0.0204	0.0204
Entamoeba histolytica	PH domain containing protein	0.0424	0.0204	0.0204
Entamoeba histolytica	hypothetical protein, conserved	0.0424	0.0204	0.0204
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0111	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.5156	0.3285	0.3285
Brugia malayi	Oxysterol binding protein	0.0424	0.0204	0.0204
Entamoeba histolytica	PH domain containing protein kinase, putative	1.0425	0.6715	0.6715
Brugia malayi	Cytohesin 3	0.0424	0.0204	0.0204
Onchocerca volvulus		0.0424	0.0204	1
Entamoeba histolytica	protein kinase, putative	0.0535	0.0276	0.0276
Echinococcus granulosus	dynamin 1	0.0424	0.0204	0.0304
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.5156	0.3285	0.4891
Echinococcus multilocularis	dynamin 1	0.0424	0.0204	0.0304
Schistosoma mansoni	hypothetical protein	0.0424	0.0204	0.0304
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Echinococcus multilocularis	serine:threonine protein kinase N2	0.5156	0.3285	0.4891
Trypanosoma cruzi	rac serine-threonine kinase, putative	1.0425	0.6715	1
Trypanosoma brucei	rac serine-threonine kinase, putative	1.547	1	1
Brugia malayi	p70 ribosomal S6 kinase beta	1.5046	0.9724	0.9724
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.5156	0.3285	0.4891
Onchocerca volvulus		0.0424	0.0204	1
Loa Loa (eye worm)	oxysterol binding protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	probable spectrin beta chain	0.0424	0.0204	0.0204
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0111	0	0.5
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0424	0.0204	0.0304
Echinococcus granulosus	protein kinase c epsilon type	0.5156	0.3285	0.4891
Schistosoma mansoni	oxysterol-binding protein 1	0.0424	0.0204	0.0304
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0535	0.0276	0.0411
Trichomonas vaginalis	protein transport protein sec7, putative	0.0424	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	MAX-1A	0.0424	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Schistosoma mansoni	zinc finger protein	0.0424	0.0204	0.0304
Schistosoma mansoni	dynamin	0.0424	0.0204	0.0304
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0424	0.0204	0.0204
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.989	0.6367	0.9481
Loa Loa (eye worm)	uncoordinated protein 104	0.0424	0.0204	0.0204
Giardia lamblia	Kinase, AGC PKA	1.0001	0.6439	1
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Entamoeba histolytica	PH domain containing protein	0.0424	0.0204	0.0204
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Echinococcus multilocularis	Pleckstrin y	0.0424	0.0204	0.0304
Entamoeba histolytica	hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0535	0.0276	0.0276
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0111	0	0.5
Brugia malayi	Pleckstrin Homology Domain	0.0424	0.0204	0.0204
Trichomonas vaginalis	centaurin alpha, putative	0.0424	0.0204	0.0204
Echinococcus granulosus	Protein kinase C brain isozyme	0.5156	0.3285	0.4891
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0535	0.0276	0.0411
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Echinococcus granulosus	NDR protein kinase	0.5156	0.3285	0.4891
Echinococcus multilocularis	serine:threonine protein kinase N2	0.5156	0.3285	0.4891
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.5156	0.3285	0.4891
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0424	0.0204	0.0304
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0535	0.0276	0.0276
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Entamoeba histolytica	hypothetical protein	0.0424	0.0204	0.0204
Entamoeba histolytica	protein kinase, putative	0.0535	0.0276	0.0276
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0535	0.0276	0.0411
Entamoeba histolytica	hypothetical protein	0.0424	0.0204	0.0204
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0535	0.0276	0.0276
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0535	0.0276	0.0276
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Brugia malayi	Plekhf2 protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0424	0.0204	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Trichomonas vaginalis	centaurin beta, putative	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Echinococcus multilocularis	beta 1 syntrophin	0.0424	0.0204	0.0304
Trichomonas vaginalis	kinesin light chain, putative	0.0424	0.0204	0.0204
Echinococcus granulosus	pdz domain containing protein	0.0424	0.0204	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0424	0.0204	0.0317
Echinococcus multilocularis	Pleckstrin y	0.0424	0.0204	0.0304
Brugia malayi	PH domain containing protein	0.0424	0.0204	0.0204
Trypanosoma brucei	PH domain containing protein, putative	0.0424	0.0204	0.0204
Entamoeba histolytica	p21-activated kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	hypothetical protein	0.0424	0.0204	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Trichomonas vaginalis	AGC family protein kinase	0.5156	0.3285	0.3285
Schistosoma mansoni	serine/threonine protein kinase	0.5156	0.3285	0.4891
Echinococcus multilocularis	Pleckstrin y	0.0424	0.0204	0.0304
Echinococcus granulosus	myotubularin protein 13	0.0424	0.0204	0.0304
Echinococcus granulosus	Pleckstrin y	0.0424	0.0204	0.0304
Toxoplasma gondii	AtPH1 family protein	0.0424	0.0204	0.021
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0424	0.0204	0.0304
Schistosoma mansoni	metabotropic glutamate receptor	0.02	0.0058	0.0086
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0111	0	0.5
Schistosoma mansoni	oxysterol-binding protein 1	0.0424	0.0204	0.0304
Schistosoma mansoni	rho gtpase activating protein	0.0424	0.0204	0.0304
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Echinococcus granulosus	protein kinase C gamma type	0.5156	0.3285	0.4891
Schistosoma mansoni	serine/threonine-protein kinase	1.0425	0.6715	1
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0424	0.0204	0.0317
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0535	0.0276	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	1.5046	0.9724	0.9724
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0535	0.0276	0.0429
Echinococcus granulosus	nervana 2	0.989	0.6367	0.9481
Echinococcus multilocularis	protein kinase c iota type	0.5156	0.3285	0.4891
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	PH domain containing protein, putative	0.0424	0.0204	0.0304
Brugia malayi	TBC domain containing protein	0.0424	0.0204	0.0204
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0424	0.0204	0.0204
Echinococcus granulosus	oxysterol binding protein 1	0.0424	0.0204	0.0304
Entamoeba histolytica	PH domain containing protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	rac serine-threonine kinase, putative	1.0001	0.6439	0.9589
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0111	0	0.5
Chlamydia trachomatis	serine/threonine-protein kinase	0.0111	0	0.5
Brugia malayi	Dynamin	0.0424	0.0204	0.0204
Trichomonas vaginalis	centaurin gamma, putative	0.0424	0.0204	0.0204
Schistosoma mansoni	growth factor receptor-bound protein	0.0424	0.0204	0.0304
Echinococcus granulosus	GRB2 associated binding protein 3	0.0424	0.0204	0.0304
Trichomonas vaginalis	alpha chimerin, putative	0.0424	0.0204	0.0204
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0111	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.0204	0.0204
Brugia malayi	Uncoordinated protein 104	0.0424	0.0204	0.0204
Echinococcus multilocularis	serine threonine protein kinase	0.5156	0.3285	0.4891
Chlamydia trachomatis	serine/threonine protein kinase	0.0111	0	0.5
Schistosoma mansoni	vav2	0.0424	0.0204	0.0304
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.5156	0.3285	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0204	0.0204
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0535	0.0276	0.0411
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0424	0.0204	0.0304
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0424	0.0204	0.0304
Entamoeba histolytica	PH domain containing protein kinase, putative	1.0425	0.6715	0.6715
Brugia malayi	Dynamin	0.0424	0.0204	0.0204
Entamoeba histolytica	hypothetical protein	0.0424	0.0204	0.0204
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.5156	0.3285	0.4891
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0424	0.0204	0.0304
Echinococcus granulosus	calcium dependent secretion activator 1	0.0424	0.0204	0.0304
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0111	0	0.5
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	1.547	1	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.5156	0.3285	0.4891
Loa Loa (eye worm)	PH domain-containing protein	0.0424	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0535	0.0276	0.0276

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.4 uM	Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay	ChEMBL.	23465611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2349589

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1757730