Detailed information for compound 1757962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 583.719 | Formula: C29H33N3O6S2
  • H donors: 1 H acceptors: 6 LogP: 3.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@@H](C)[C@@H](Oc2c(S1(=O)=O)ccc(c2)C#Cc1ccncc1)CN(S(=O)(=O)c1ccc(cc1)C)C)C
  • InChi: 1S/C29H33N3O6S2/c1-21-5-10-26(11-6-21)39(34,35)31(4)19-28-22(2)18-32(23(3)20-33)40(36,37)29-12-9-25(17-27(29)38-28)8-7-24-13-15-30-16-14-24/h5-6,9-17,22-23,28,33H,18-20H2,1-4H3/t22-,23-,28+/m1/s1
  • InChiKey: GOIFBKSVWMRRGJ-MRJKTFCFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.0536 0.1095
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Echinococcus granulosus BC026374 protein S09 family 0.0125 0.068 0.1513
Onchocerca volvulus Peroxidasin homolog 0.0069 0.0342 0.1395
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1661 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0192 0.0221
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.026
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.0536 0.0536
Brugia malayi Carboxylesterase family protein 0.0125 0.068 0.068
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Schistosoma mansoni myosin xvIII 0.0101 0.0536 0.1187
Schistosoma mansoni hypothetical protein 0.0101 0.0536 0.1187
Brugia malayi Bromodomain containing protein 0.0074 0.0371 0.0371
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0019 0.0019
Brugia malayi hypothetical protein 0.0069 0.0342 0.0342
Schistosoma mansoni opsin-like receptor 0.0101 0.0536 0.1187
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0027 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0023 0.0011
Brugia malayi Bromodomain containing protein 0.0031 0.0113 0.0113
Brugia malayi Blistered cuticle protein 3 0.0069 0.0342 0.0342
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0023 0.0021
Loa Loa (eye worm) carboxylesterase 0.0125 0.068 0.0843
Onchocerca volvulus 0.0101 0.0536 0.2229
Schistosoma mansoni gliotactin 0.0125 0.068 0.1517
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.1847
Brugia malayi larval opioid receptor 0.0101 0.0536 0.0536
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.002 0.0049 0.0064
Schistosoma mansoni hypothetical protein 0.0105 0.0555 0.1232
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.0536 0.0659
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.028 0.0598
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0037 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0536 0.1095
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.0536 0.0659
Brugia malayi Melatonin receptor type 1A 0.0101 0.0536 0.0536
Brugia malayi jmjC domain containing protein 0.0037 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0741 0.439 0.5572
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Echinococcus granulosus fmrfamide receptor 0.0101 0.0536 0.1183
Brugia malayi Pre-SET motif family protein 0.0205 0.1162 0.1162
Schistosoma mansoni opsin-like receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.0536 0.1095
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0074
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Brugia malayi PHD-finger family protein 0.0029 0.0099 0.0099
Echinococcus multilocularis serotonin receptor 0.0101 0.0536 0.1095
Brugia malayi Carboxylesterase family protein 0.0741 0.439 0.439
Echinococcus multilocularis neuropeptide receptor 0.0101 0.0536 0.1095
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0536 0.0659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0103 0.0198
Onchocerca volvulus 0.0101 0.0536 0.2229
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0125 0.068 0.873
Brugia malayi Calcitonin receptor-like protein seb-1 0.0065 0.0315 0.0315
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0401 0.2339 0.4914
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0023 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Echinococcus multilocularis sex peptide receptor 0.0101 0.0536 0.1095
Brugia malayi PHD-finger family protein 0.0025 0.0073 0.0073
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0536 0.1095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0019 0.0005
Echinococcus granulosus peroxidasin 0.0069 0.0342 0.0741
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0536 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Onchocerca volvulus 0.0125 0.068 0.285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.0536 0.1095
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0342 0.0342
Onchocerca volvulus 0.0401 0.2339 1
Echinococcus multilocularis GPCR, family 2 0.002 0.0049 0.0064
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0059 0.0087
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.0536 0.1183
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0023 0.3318
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0064 0.0369
Onchocerca volvulus 0.0291 0.1677 0.7144
Echinococcus granulosus somatostatin receptor 0.0101 0.0536 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0019 0.0019
Onchocerca volvulus Alhambra homolog 0.0029 0.0099 0.0345
Schistosoma mansoni hypothetical protein 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Onchocerca volvulus 0.0125 0.068 0.285
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.0536 0.1183
Echinococcus granulosus g protein coupled receptor 0.0101 0.0536 0.1183
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0064 0.5453
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0135 0.0247
Loa Loa (eye worm) hypothetical protein 0.0353 0.2055 0.2596
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0536 0.1187
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.0536 0.1187
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.0536 0.0536
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.0536 0.1095
Schistosoma mansoni amine GPCR 0.0101 0.0536 0.1187
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Onchocerca volvulus 0.0101 0.0536 0.2229
Echinococcus granulosus hypothetical protein 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.1318 0.7864 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0016 0.0023 0.0021
Onchocerca volvulus 0.0101 0.0536 0.2229
Schistosoma mansoni neuropeptide receptor 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0023 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Brugia malayi RE15519p 0.0101 0.0536 0.0536
Echinococcus granulosus neuropeptide s receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.0401 0.2339 0.2958
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.002 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Echinococcus granulosus g protein coupled receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) acetylcholinesterase 1 0.0741 0.439 0.5572
Onchocerca volvulus 0.0029 0.0103 0.0363
Echinococcus granulosus acetylcholinesterase 0.0741 0.439 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0125 0.068 0.285
Echinococcus multilocularis acetylcholinesterase 0.0741 0.439 0.9257
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0773 1
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0536 0.1183
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0146 0.0297
Brugia malayi neuropeptide F receptor 0.0101 0.0536 0.0536
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0103 0.0178
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0204 0.0429
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0019 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.0536 0.1183
Loa Loa (eye worm) carboxylesterase 0.0125 0.068 0.0843
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.068 0.1517
Mycobacterium tuberculosis Carboxylesterase LipT 0.0125 0.068 0.873
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0023 0.3318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0342 0.0413
Echinococcus multilocularis peroxidasin 0.0069 0.0342 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0019 0.0019
Trypanosoma brucei RNA helicase, putative 0.0105 0.0555 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0074
Brugia malayi Latrophilin receptor protein 2 0.002 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus granulosus carboxylesterase 5A 0.0741 0.439 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.002 0.0049 0.0038
Schistosoma mansoni biogenic amine receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis cysteine protease 0.0016 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0346 0.0417
Mycobacterium ulcerans carboxylesterase, LipT 0.0125 0.068 0.873
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Loa Loa (eye worm) hypothetical protein 0.0065 0.0315 0.0378
Loa Loa (eye worm) carboxylesterase 0.0741 0.439 0.5572
Trypanosoma cruzi cruzipain precursor, putative 0.0016 0.0023 0.3318
Brugia malayi G-protein coupled receptor 0.0101 0.0536 0.0536
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0099 0.0188
Echinococcus multilocularis peregrin 0.0031 0.0113 0.0199
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.0536 0.1187
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0536 0.1183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0536 0.1183
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.0536 0.2229
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0536 0.1183
Brugia malayi Bromodomain containing protein 0.0038 0.0153 0.0153
Onchocerca volvulus 0.0101 0.0536 0.2229
Onchocerca volvulus 0.0125 0.068 0.285
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.003 0.0015
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.0536 0.1183
Echinococcus granulosus peregrin 0.0031 0.0113 0.0215
Schistosoma mansoni zinc finger protein 0.0019 0.0042 0.0058
Echinococcus granulosus para nitrobenzyl esterase 0.0125 0.068 0.1513
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0773 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0099 0.0183
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0342 0.0342
Onchocerca volvulus 0.0016 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0153 0.0172
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.019
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0799 0.4741 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0059 0.0094
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0125 0.068 0.873
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Onchocerca volvulus 0.0233 0.1332 0.566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.061 0.3599 0.8191
Onchocerca volvulus 0.0069 0.0342 0.1395
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0125 0.068 0.4009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.0536 0.1095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Brugia malayi hypothetical protein 0.0101 0.0536 0.0536
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0065 0.0315 0.0378
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0342 0.0342
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis allatostatin A receptor 0.0101 0.0536 0.1095
Echinococcus granulosus inhibitor of apoptosis protein 0.0401 0.2339 0.5309
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0023 0.3318
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus multilocularis BC026374 protein (S09 family) 0.0125 0.068 0.14
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0283 0.0337
Onchocerca volvulus 0.0101 0.0536 0.2229
Schistosoma mansoni biogenic amine receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis neuroligin 0.0125 0.068 0.14
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0027 0.0018
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0125 0.068 0.14
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0064 0.0369
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0493 0.1084
Echinococcus granulosus zinc finger protein 0.0019 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0536 0.1095
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.0536 0.1183
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0536 0.1095
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0342 0.0413
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0099 0.0102
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.068 0.1517
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.0536 0.1187
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0019 0.0019
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0048
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0064 0.5169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0023 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0536 0.1187
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0342 0.0413
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0419 0.0849
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.0085
Schistosoma mansoni neuropeptide receptor 0.0101 0.0536 0.1187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.0536 0.1187
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0536 0.1095
Schistosoma mansoni neuropeptide receptor 0.0101 0.0536 0.1187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.0536 0.1095
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Onchocerca volvulus 0.0101 0.0536 0.2229
Onchocerca volvulus 0.0016 0.0023 0.0021
Schistosoma mansoni amine GPCR 0.0101 0.0536 0.1187
Onchocerca volvulus 0.0082 0.0419 0.1727
Echinococcus multilocularis cysteine protease 0.0016 0.0023 0.001
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Brugia malayi Carboxylesterase family protein 0.0741 0.439 0.439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0006
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0401 0.2339 0.5309
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.0536 0.0536
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.0536 0.1095
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0139 0.0255
Schistosoma mansoni hypothetical protein 0.0029 0.0099 0.0188
Echinococcus granulosus sex peptide receptor 0.0101 0.0536 0.1183
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0023 0.0016
Onchocerca volvulus Peroxidasin homolog 0.0069 0.0342 0.1395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0708 0.4191 0.5318
Toxoplasma gondii exonuclease III APE 0.0019 0.0037 0.1751
Schistosoma mansoni hypothetical protein 0.0044 0.0192 0.0401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0019 0.0005
Echinococcus granulosus serotonin receptor 0.0101 0.0536 0.1183
Brugia malayi GnHR receptor homolog 0.0101 0.0536 0.0536
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0019 0.0005
Echinococcus granulosus neuropeptide receptor 0.0101 0.0536 0.1183
Echinococcus multilocularis para nitrobenzyl esterase 0.0125 0.068 0.14
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0037 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0019 0.0005
Echinococcus multilocularis acetylcholinesterase 0.0741 0.439 0.9257
Brugia malayi Peroxidasin 0.0069 0.0342 0.0342
Onchocerca volvulus 0.0016 0.0023 0.0021
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0401 0.2339 0.2339
Onchocerca volvulus Dual oxidase homolog 0.0069 0.0342 0.1395
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0536 0.1187
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1162 0.1457
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0096 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0536 0.1183
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0037 0.1751
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0064 0.5169
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0536 0.1095
Brugia malayi Dopamine receptor 0.0101 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0251
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0099 0.9479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0536 0.1095
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.0536 0.1187
Loa Loa (eye worm) blistered cuticle protein 3 0.0069 0.0342 0.0413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0204 0.0237
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0536 0.1183
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0037 0.0043
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0536 0.1095
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.0536 0.0536
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0146 0.0163
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0074
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0064 0.5169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0037 0.0085
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0023 0.144
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0072
Schistosoma mansoni neuroligin 3 (S09 family) 0.0125 0.068 0.1517
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.002 0.0049 0.0064
Schistosoma mansoni hypothetical protein 0.0401 0.2339 0.5311
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0023 0.3318
Onchocerca volvulus Chorion peroxidase homolog 0.0069 0.0342 0.1395
Echinococcus multilocularis serotonin receptor 0.0101 0.0536 0.1095
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0019 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.0536 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0019 0.0019
Echinococcus granulosus cathepsin l1 0.0016 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Echinococcus multilocularis zinc finger protein 0.0019 0.0042 0.0049
Onchocerca volvulus 0.0016 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0016 0.0023 0.0021
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.0536 0.1187
Onchocerca volvulus 0.0101 0.0536 0.2229
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0773 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0419 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Onchocerca volvulus 0.0101 0.0536 0.2229
Onchocerca volvulus 0.0101 0.0536 0.2229
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0048 0.0038
Schistosoma mansoni acetylcholinesterase 0.0125 0.068 0.1517
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0204 0.0424
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0741 0.439 1
Schistosoma mansoni hypothetical protein 0.0101 0.0536 0.1187
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0037 0.4339
Plasmodium falciparum phd finger protein, putative 0.0029 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0099 0.9479
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.0536 0.1095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0103 0.0198
Echinococcus granulosus allatostatin A receptor 0.0101 0.0536 0.1183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0023 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0037 0.0024
Echinococcus granulosus neuroligin 0.0125 0.068 0.1513
Brugia malayi Serotonin receptor 0.0101 0.0536 0.0536
Echinococcus granulosus GPCR family 2 0.002 0.0049 0.0069
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Echinococcus multilocularis somatostatin receptor 0.0101 0.0536 0.1095
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0064 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.0342 0.0413
Giardia lamblia PHD finger protein 15 0.0029 0.0099 0.0378
Schistosoma mansoni bromodomain containing protein 0.0062 0.0301 0.0651
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus Deterin homolog 0.0401 0.2339 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Brugia malayi Dopamine receptor protein 1 0.0101 0.0536 0.0536
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.0536 0.1095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0536 0.1187
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0103 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Brugia malayi sulfakinin receptor protein 0.0101 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0069 0.0342 0.0413
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0401 0.2339 0.2339
Brugia malayi latrophilin 2 splice variant baaae 0.0044 0.0192 0.0192
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0069 0.0342 0.1395
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.0536 0.0659
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0019 0.0005
Schistosoma mansoni inhibitor of apoptosis protein 0.0401 0.2339 0.5311
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.0536 0.1095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0019 0.0019
Brugia malayi putative neuropeptide receptor 0.0101 0.0536 0.0536
Onchocerca volvulus Peroxidase homolog 0.0069 0.0342 0.1395
Schistosoma mansoni opsin-like receptor 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi ORL1-like opioid receptor 0.0101 0.0536 0.0536
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.0536 0.1183
Brugia malayi Carboxylesterase family protein 0.0125 0.068 0.068
Schistosoma mansoni neuropeptide receptor 0.0101 0.0536 0.1187
Brugia malayi Pre-SET motif family protein 0.0029 0.0103 0.0103
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0019 0.0019
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0146 0.0293
Brugia malayi G protein-coupled receptor 0.0101 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0101 0.0536 0.1187
Echinococcus granulosus g protein coupled receptor 0.0101 0.0536 0.1183
Echinococcus granulosus neuropeptide receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.1677 0.2113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.0536 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.0536 0.0536
Trichomonas vaginalis spcc417.12 protein, putative 0.0125 0.068 0.4009
Schistosoma mansoni biogenic amine receptor 0.0101 0.0536 0.1187
Brugia malayi follicle stimulating hormone receptor 0.0101 0.0536 0.0536
Brugia malayi Serotonin receptor 0.0101 0.0536 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Echinococcus multilocularis inhibitor of apoptosis protein 0.0401 0.2339 0.4914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.0536 0.1183
Brugia malayi Cathepsin L-like precursor 0.0016 0.0023 0.0023
Echinococcus granulosus g-protein coupled receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Plasmodium vivax SET domain protein, putative 0.0029 0.0103 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0099 0.017
Schistosoma mansoni peroxidasin 0.0069 0.0342 0.0745
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0125 0.068 0.285
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.0125 0.068 0.0843
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.0536 0.1183
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0376 0.0822
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1661 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0101 0.0536 0.2229
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.0536 0.0536
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1661 1
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.0536 0.1095
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0741 0.439 0.5572
Brugia malayi Carboxylesterase family protein 0.0125 0.068 0.068
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0536 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0037 0.004
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0064 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0536 0.1187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0204 0.0429
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi Dopamine receptor protein 2 0.0101 0.0536 0.0536
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.0536 0.1187
Onchocerca volvulus Peroxidase homolog 0.0069 0.0342 0.1395
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0536 0.1095
Echinococcus granulosus orexin receptor type 2 0.0101 0.0536 0.1183
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0536 0.1095
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0166 0.0313
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.0536 0.2229
Brugia malayi nuclear receptor NHR-88 0.0015 0.0019 0.0019
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0042 0.0179 0.0204
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0023 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0037 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0064 0.0369
Echinococcus granulosus jumonji domain containing protein 0.004 0.0166 0.0338
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0125 0.068 0.1517
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0064 0.0891
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi Carboxylesterase family protein 0.0125 0.068 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0023 0.0128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0065 0.0315 0.0315
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.002 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Echinococcus multilocularis orexin receptor type 2 0.0101 0.0536 0.1095
Schistosoma mansoni amine GPCR 0.0101 0.0536 0.1187
Onchocerca volvulus 0.0069 0.0342 0.1395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Brugia malayi G-protein coupled receptor 0.0101 0.0536 0.0536
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.0387
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0401 0.2339 0.5311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0536 0.1095
Onchocerca volvulus 0.0101 0.0536 0.2229
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.0536 0.1187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0536 0.1183
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0536 0.1095
Loa Loa (eye worm) fibroinase 0.0016 0.0023 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0019 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0101 0.0536 0.1095
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0099 0.9479
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0059 0.0098
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0536 0.1183
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.0536 0.1095
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0204 0.0393
Echinococcus granulosus acetylcholinesterase 0.0741 0.439 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1661 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0064 1
Onchocerca volvulus 0.0101 0.0536 0.2229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0536 0.1095
Brugia malayi steroid hormone receptor 0.0015 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0101 0.0536 0.1187
Schistosoma mansoni adenoreceptor 0.0101 0.0536 0.1187
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.0536 0.1183
Schistosoma mansoni amine GPCR 0.0101 0.0536 0.1187
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0536 0.1095
Onchocerca volvulus 0.0101 0.0536 0.2229
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0023 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0069 0.0342 0.0342
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.0536 0.1183
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0419 0.0917
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0536 0.1095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0139 0.0275
Schistosoma mansoni histamine h1 receptor 0.0101 0.0536 0.1187
Brugia malayi nuclear hormone receptor 0.0015 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0536 0.1187
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.0536 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0019 0.0019
Brugia malayi ecdysteroid receptor 0.0015 0.0019 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0019 0.0005
Onchocerca volvulus 0.0016 0.0023 0.0021
Onchocerca volvulus 0.0101 0.0536 0.2229
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0536 0.0659
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1332 0.7991
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0019 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.028 0.0554
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0536 0.1183
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0536 0.1183
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0146 0.0297
Loa Loa (eye worm) hypothetical protein 0.0401 0.2339 0.2958
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.0536 0.1183
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0493 0.1004
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0536 0.1095
Brugia malayi jmjC domain containing protein 0.0094 0.0493 0.0493
Brugia malayi hypothetical protein 0.0125 0.068 0.068
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.0536 0.0659
Loa Loa (eye worm) cysteine protease 0.0016 0.0023 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0023 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.0536 0.1095
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0064 0.0167
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Onchocerca volvulus 0.0101 0.0536 0.2229
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0536 0.0659
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0019 0.0019
Brugia malayi Pax transcription factor protein 2 0.0291 0.1677 0.1677
Loa Loa (eye worm) hypothetical protein 0.0101 0.0536 0.0659
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1661 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.0536 0.1095
Echinococcus multilocularis carboxylesterase 5A 0.0741 0.439 0.9257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0023 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.0536 0.1095
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.0536 0.0536
Schistosoma mansoni peroxidasin 0.0069 0.0342 0.0745
Schistosoma mansoni BC026374 protein (S09 family) 0.0125 0.068 0.1517
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0536 0.1187
Schistosoma mansoni coup transcription factor 0.0015 0.0019 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.002 0.0049 0.0069
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.0536 0.1183
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0023 0.0021
Brugia malayi AKH receptor 0.0101 0.0536 0.0536
Leishmania major cathepsin L-like protease 0.0016 0.0023 0.144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0019 0.0019
Onchocerca volvulus 0.0101 0.0536 0.2229
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0023 0.0023
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0125 0.068 0.1513
Loa Loa (eye worm) hypothetical protein 0.0082 0.0419 0.0511
Brugia malayi neuropeptide F receptor 0.0101 0.0536 0.0536

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.05 uM PubChem BioAssay. SA5-Pax8: Cytotoxicity IOSE-T80 Measured in Cell-Based System Using Plate Reader - 7054-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) = 3.3 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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