Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.068 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 0.9883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.068 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0676 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.068 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.068 | 1 | 0.5 |
Onchocerca volvulus | 0.0337 | 0 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 0.9883 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 0.9883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.068 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 0.9883 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 0.9883 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 0.9883 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 0.9883 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 0.9883 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 25 uM | Inhibition of CYP2B1 (unknown origin)-mediated depentylation of resorufin pentyl ether after 5 mins by spectrofluorimetric analysis | ChEMBL. | 23600958 |
IC50 (ADMET) | > 25 uM | Inhibition of CYP2A6 (unknown origin)-mediated coumarin 7-hydroxylation after 5 mins by spectrofluorimetric analysis | ChEMBL. | 23600958 |
Inhibition (ADMET) | Inhibition of CYP1B1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis | ChEMBL. | 23600958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.