Detailed information for compound 1758468

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 737.687 | Formula: C35H42Cl2N2O9S
  • H donors: 1 H acceptors: 4 LogP: 6.19 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(CC[C@H](c2cccc(c2)OCCN2CCOCC2)OC(=O)C2CCCCN2S(=O)(=O)c2cc(Cl)c(c(c2)Cl)O)ccc1OC
  • InChi: 1S/C35H42Cl2N2O9S/c1-44-32-12-10-24(20-33(32)45-2)9-11-31(25-6-5-7-26(21-25)47-19-16-38-14-17-46-18-15-38)48-35(41)30-8-3-4-13-39(30)49(42,43)27-22-28(36)34(40)29(37)23-27/h5-7,10,12,20-23,30-31,40H,3-4,8-9,11,13-19H2,1-2H3/t30?,31-/m1/s1
  • InChiKey: TVGYPBVOGSTTOF-NLIBRCFJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0018 0.0435 0.078
Toxoplasma gondii transporter, cation channel family protein 0.005 0.189 0.7057
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0435 0.0622
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0067 0.2677 0.2677
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0258 0.0257
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.1257 0.207
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.1257 0.225
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0018 0.0435 0.0608
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.1257 0.1609
Brugia malayi Cytochrome P450 family protein 0.0014 0.0263 0.0262
Onchocerca volvulus 0.0019 0.0466 0.0596
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.1997 0.1996
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.1257 0.207
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0115 0.4891 0.489
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0435 0.0622
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0258 0.0257
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.013 0.5583 0.9332
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0018 0.0435 0.0434
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.013 0.5583 1
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.1257 0.1256
Loa Loa (eye worm) FKBP5 protein 0.013 0.5583 0.5582
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0043 0.1561 0.1561
Loa Loa (eye worm) hypothetical protein 0.005 0.189 0.1889
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0227 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0263 0.0438
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.013 0.5583 0.9332
Echinococcus granulosus voltage dependent calcium channel 0.0227 1 1
Leishmania major fk506-binding protein 1-like protein 0.013 0.5583 1
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0263 0.0262
Plasmodium vivax unspecified product 0.0067 0.2677 0.4356
Loa Loa (eye worm) hypothetical protein 0.0041 0.1503 0.1502
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0067 0.2677 0.4356
Trypanosoma brucei Casein kinase II 0.0067 0.2677 0.4475
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.013 0.5583 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0076 0.0075
Brugia malayi Casein kinase II, alpha chain 0.0067 0.2677 0.2677
Toxoplasma gondii hypothetical protein 0.0041 0.1503 0.5611
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0435 0.0622
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Trichomonas vaginalis fk506-binding protein, putative 0.0018 0.0435 0.0622
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0018 0.0435 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0437 0.0436
Brugia malayi Csnk2b protein 0.0036 0.1257 0.1256
Schistosoma mansoni immunophilin 0.0133 0.5712 0.5712
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.0227 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.013 0.5583 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0258 0.0257
Onchocerca volvulus 0.0018 0.0435 0.0556
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.013 0.5583 0.5582
Loa Loa (eye worm) hypothetical protein 0.0014 0.0258 0.0257
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.018 0.0179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0258 0.0299
Brugia malayi Cytochrome P450 family protein 0.0014 0.0263 0.0262
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.013 0.5583 0.9332
Mycobacterium ulcerans hypothetical protein 0.0018 0.0435 0.0325
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0139 0.5982 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0133 0.5712 0.5712
Brugia malayi casein kinase II, putaitve 0.001 0.0094 0.0093
Giardia lamblia Kinase, CMGC CK2 0.0067 0.2677 0.4707
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0263 0.0262
Trichomonas vaginalis fk506-binding protein, putative 0.013 0.5583 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.4792 0.4792
Echinococcus multilocularis casein kinase ii subunit alpha 0.0067 0.2677 0.2677
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0227 1 1
Giardia lamblia Hypothetical protein 0.0018 0.0435 0.0622
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0179 0.7808 0.7808
Toxoplasma gondii CMGC kinase, CK2 family 0.0067 0.2677 1
Loa Loa (eye worm) Csnk2b protein 0.0036 0.1257 0.1256
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0435 0.0726
Echinococcus multilocularis voltage dependent calcium channel 0.0227 1 1
Leishmania major cytochrome p450-like protein 0.0014 0.0263 0.0469
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.1257 0.207
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0263 0.0438
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0263 0.0262
Schistosoma mansoni immunophilin 0.0115 0.4891 0.489
Echinococcus multilocularis voltage dependent calcium channel 0.0227 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0018 0.0437 0.0436
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.013 0.5583 0.9332
Loa Loa (eye worm) voltage-dependent calcium channel 0.005 0.189 0.1889
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0258 0.0257
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0018 0.0435 0.0778
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.013 0.5583 0.9332
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0179 0.7808 0.7808
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0227 1 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.7808 0.7808
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0258 0.0299
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0018 0.0435 0.0434
Plasmodium falciparum casein kinase 2, alpha subunit 0.0067 0.2677 0.4356
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.1818 0.1818
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0608
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0258 0.0257
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.013 0.5583 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0018 0.0435 0.0434
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0021 0.0565 0.0564
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.1431 0.2437
Loa Loa (eye worm) calcium channel 0.0227 1 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0435 0.1623
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0258 0.0257
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0133 0.5712 1
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.1257 0.1609
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.013 0.5583 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0435 0.1623
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.018 0.0179
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Brugia malayi Protein kinase domain containing protein 0.0179 0.7808 0.7808
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0437 0.0436
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.1257 0.21
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0227 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0258 0.0257
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.013 0.5583 1
Echinococcus granulosus calcium activated potassium channel 0.001 0.0069 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.7808 0.7808
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.1257 0.1256
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.013 0.5583 0.9332
Echinococcus multilocularis calcium activated potassium channel 0.001 0.0069 0.0068
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0018 0.0435 0.1623
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0018 0.0435 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.013 0.5583 1
Trichomonas vaginalis fk506-binding protein, putative 0.0018 0.0435 0.0622
Echinococcus granulosus casein kinase ii subunit alpha 0.0067 0.2677 0.2677
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0258 0.0257
Echinococcus granulosus voltage dependent calcium channel 0.005 0.189 0.1889
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0133 0.5712 0.5712
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0018 0.0437 0.0436
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.1431 0.2437
Schistosoma mansoni fk506 binding protein 0.0018 0.0435 0.0434
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.1257 0.4693
Plasmodium falciparum casein kinase II beta chain 0.0036 0.1257 0.1596
Plasmodium falciparum casein kinase II beta chain 0.0036 0.1257 0.1596
Echinococcus multilocularis sodium channel protein 0.0098 0.4093 0.4093
Trypanosoma cruzi casein kinase II, putative 0.0067 0.2677 0.4475
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0258 0.0257
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.2677 0.4598
Loa Loa (eye worm) casein kinase II 0.001 0.0094 0.0093
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0018 0.0435 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0018 0.0435 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0258 0.0257
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0098 0.4093 0.4093
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.1257 0.1596
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0115 0.4891 0.489
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.1257 0.21
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0018 0.0435 0.0434
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.1257 0.1596
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0133 0.5712 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0258 0.0257
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0258 0.0257
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0179 0.7808 0.7808
Leishmania major peptidylprolyl isomerase-like protein 0.013 0.5583 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0227 1 1
Echinococcus multilocularis fk506 binding protein 0.013 0.5583 0.5582
Schistosoma mansoni voltage-gated cation channel 0.0227 1 1
Toxoplasma gondii ck2 beta subunit 0.0036 0.1257 0.4693
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0726
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.013 0.5583 0.5582
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0258 0.0257
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0258 0.0257
Entamoeba histolytica casein kinase, putative 0.0067 0.2677 0.4598
Giardia lamblia Casein kinase II beta chain 0.0036 0.1257 0.2119
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.1818 0.1818
Trichomonas vaginalis immunophilin, putative 0.013 0.5583 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0435 0.0622
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0227 1 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.1257 0.21
Echinococcus multilocularis 0.0018 0.0435 0.0434
Echinococcus granulosus FK506 binding protein 2 0.0018 0.0435 0.0434
Leishmania major casein kinase II, putative 0.0067 0.2677 0.4795
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0018 0.0437 0.0436
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.013 0.5583 0.5582
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0435 0.1623
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0179 0.7808 0.7808
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0018 0.0435 0.0434
Schistosoma mansoni hypothetical protein 0.0018 0.0435 0.0434
Trichomonas vaginalis fk506 binding protein, putative 0.0018 0.0435 0.0622
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0778
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0018 0.0435 0.0434
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0018 0.0437 0.0436
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0227 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0258 0.0257
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.013 0.5583 0.5582
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.013 0.5583 1
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0263 0.0438
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.1997 0.1996
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0258 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.2677 0.4707
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0227 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0435 0.0622
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0018 0.0435 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0258 0.0257
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0139 0.5982 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0179 0.7808 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0258 0.0257
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0018 0.0435 0.0726
Schistosoma mansoni immunophilin 0.0133 0.5712 0.5712
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0227 1 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.1257 0.1256
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0435 0.0778
Schistosoma mansoni protein kinase 0.0067 0.2677 0.2677
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0258 0.0257
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0437 0.0436
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0018 0.0435 0.0434
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0018 0.0435 0.0726
Echinococcus granulosus voltage gated potassium channel 0.0018 0.0437 0.0436
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0131 0.5613 0.5613
Loa Loa (eye worm) hypothetical protein 0.0041 0.1503 0.1502
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.1818 0.1818
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.1257 0.2119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0435 0.0434

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.2 uM Binding affinity to human FKBP51 by competitive fluorescence polarization assay ChEMBL. 23647266

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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