Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0149 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.3131 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.3131 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.3131 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.3131 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0149 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.3131 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.3131 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0149 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.3131 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.3131 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.3131 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment G | ChEMBL. | No reference |
IC50 (binding) | = 58 nM | Inhibition of Toxoplasma gondii enoyl reductase assessed as conversion of trans-2-acyl-ACP to acyl-ACP | ChEMBL. | 23453069 |
IC50 (functional) | = 7.32 uM | AntiToxoplasma gondii activity data 2-day killing assay: IC50 (uM), Experiment F | ChEMBL. | No reference |
INH (ADMET) | > 10 uM | Cytotoxicity against HFF assessed as inhibition of [3H]-thymidine incorporation after 24 hrs by WST-1 assay | ChEMBL. | 23453069 |
Inhibition (binding) | Compound was evaluated for the inhibition of human FECH at 10uM | MMV_PBOX. | No reference | |
Inhibition (functional) | = 70 % | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment C | ChEMBL. | No reference |
Inhibition (functional) | ~ 85 % | AntiToxoplasma gondii activity data Inhibition of plaque forming efficiency (%) Experiment A | ChEMBL. | No reference |
Inhibition (binding) | = 90 % | Inhibition of Toxoplasma gondii enoyl reductase assessed as conversion of trans-2-acyl-ACP to acyl-ACP at 1 uM | ChEMBL. | 23453069 |
Inhibition (functional) | = 21.96 uM | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment E | ChEMBL. | No reference |
Inhibition (functional) | = 64.82 uM | AntiToxoplasma gondii activity data 2-day killing assay: inhibition at 10 uM (%) Experiment D | ChEMBL. | No reference |
MIC50 (functional) | = 10 uM | Antiparasitic activity against Toxoplasma gondii type 1 RH expressing YFP infected in HFF assessed as inhibition of [3H]-uracil incorporation after 72 hrs by liquid scintillation counting | ChEMBL. | 23453069 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.