Detailed information for compound 1758650

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 728.798 | Formula: C38H47F3N4O7
  • H donors: 3 H acceptors: 3 LogP: 5.88 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@@H](OCCCC[C@@H](Oc2c(C1=O)cc(cc2)NC(=O)Nc1ccc2c(c1)OCO2)C)CN(Cc1ccc(cc1)C(F)(F)F)C)C
  • InChi: 1S/C38H47F3N4O7/c1-24-19-45(25(2)22-46)36(47)31-17-29(42-37(48)43-30-13-15-33-34(18-30)51-23-50-33)12-14-32(31)52-26(3)7-5-6-16-49-35(24)21-44(4)20-27-8-10-28(11-9-27)38(39,40)41/h8-15,17-18,24-26,35,46H,5-7,16,19-23H2,1-4H3,(H2,42,43,48)/t24-,25+,26-,35-/m0/s1
  • InChiKey: WRYGCPSZOBAIIH-LFSBMLFJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0005 0.0005
Schistosoma mansoni 60S ribosomal protein L21 0.0016 0.0001 0.0001
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0005 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0015 0.0015
Loa Loa (eye worm) solute carrier family 6 member 4 0.0284 0.0714 0.0714
Loa Loa (eye worm) carboxylesterase 0.0199 0.0489 0.0489
Mycobacterium ulcerans carboxylesterase, LipT 0.0199 0.0489 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0118 0.0273 0.0273
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Onchocerca volvulus 0.0291 0.0732 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0015 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Schistosoma mansoni gliotactin 0.0199 0.0489 0.0489
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0087 0.0087
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0015 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0015 0.0015
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0118 0.0273 0.0273
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1112 0.2917 0.2911
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0199 0.0489 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0058 0.0053
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0005 0.0005
Loa Loa (eye worm) gastrulation defective protein 1 0.117 0.307 0.307
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0797 0.2079 0.2079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi Carboxylesterase family protein 0.0199 0.0489 0.0489
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0005 0.0005
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0199 0.0489 0.0489
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Loa Loa (eye worm) hypothetical protein 0.0044 0.0077 0.0077
Onchocerca volvulus 0.0199 0.0489 0.6228
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0101 0.0101
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.049 0.1263 0.1263
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.1179 0.3095 0.3095
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0273 0.0273
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0118 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0118 0.0273 0.0273
Echinococcus multilocularis cyclin dependent kinase 19 0.1174 0.3081 0.3081
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0005 0.0005
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.005 0.0091 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Plasmodium falciparum amino acid transporter, putative 0.0048 0.0087 0.0079
Plasmodium falciparum transporter, putative 0.0048 0.0087 0.0079
Echinococcus granulosus ankyrin repeat protein 0.0313 0.0791 0.0791
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi Cyclin C 0.1606 0.4231 0.4231
Trypanosoma brucei N-myristoyl transferase, putative 0.3775 1 1
Schistosoma mansoni N-myristoyltransferase 0.3775 1 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.1112 0.2917 0.2917
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0048 0.0087 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0005 0.0005
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0273 0.0273
Echinococcus multilocularis para nitrobenzyl esterase 0.0199 0.0489 0.0489
Echinococcus granulosus transient receptor potential cation channel 0.0325 0.0824 0.0824
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii hypothetical protein 0.0048 0.0087 0.0272
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0284 0.0714 0.0714
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1112 0.2917 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Schistosoma mansoni g1/s-specific cyclin C 0.1606 0.4231 0.4231
Leishmania major hypothetical protein, conserved 0.0118 0.0273 0.0265
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0087
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.3775 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0797 0.2079 0.2079
Onchocerca volvulus 0.0199 0.0489 0.6228
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0235 0.0584 0.0584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0284 0.0714 0.0714
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0797 0.2079 0.2079
Giardia lamblia hypothetical protein 0.0118 0.0273 0.0265
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0273 0.0265
Schistosoma mansoni hypothetical protein 0.0034 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0118 0.0273 0.0273
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0272
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.0489 0.0489
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0005 0.0005
Trypanosoma cruzi N-myristoyl transferase, putative 0.3775 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0098 0.0098
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0048 0.0087 0.0087
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0199 0.0489 0.0489
Brugia malayi Carboxylesterase family protein 0.0199 0.0489 0.0489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Echinococcus multilocularis BC026374 protein (S09 family) 0.0199 0.0489 0.0489
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0008
Plasmodium vivax phosphodiesterase gamma, putative 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Loa Loa (eye worm) PDE1B protein 0.049 0.1263 0.1263
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0313 0.0791 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.013 0.0306 0.1024
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0235 0.0584 0.0584
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0087
Echinococcus multilocularis ankyrin repeat protein 0.0313 0.0791 0.0791
Loa Loa (eye worm) N-myristoyltransferase 2 0.3775 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Plasmodium falciparum phosphodiesterase delta, putative 0.0118 0.0273 0.0265
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.0489 0.0489
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Loa Loa (eye worm) cyclin C 0.1606 0.4231 0.4231
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Echinococcus multilocularis calcium activated potassium channel 0.0016 0.0002 0.0002
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0584 0.0577
Loa Loa (eye worm) cyclin domain-containing protein 0.0797 0.2079 0.2079
Onchocerca volvulus 0.0284 0.0714 0.9726
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0118 0.0273 0.0273
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0058 0.0053
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0005 0.0005
Echinococcus granulosus calcium activated potassium channel 0.0016 0.0002 0.0002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Loa Loa (eye worm) carboxylesterase 0.1179 0.3095 0.3095
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1112 0.2917 0.2917
Loa Loa (eye worm) serotonin transporter b 0.0284 0.0714 0.0714
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0008 0.5
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.1179 0.3095 0.3095
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0048 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.0199 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.3775 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0273 0.0265
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus BC026374 protein S09 family 0.0199 0.0489 0.0489
Brugia malayi Protein kinase domain containing protein 0.1174 0.3081 0.3081
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0118 0.0273 0.0273
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1179 0.3095 0.3095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0089 0.0089
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0273 0.0273
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii hypothetical protein 0.0048 0.0087 0.0272
Echinococcus multilocularis serotonin transporter 0.0284 0.0714 0.0714
Schistosoma mansoni sodium/chloride dependent transporter 0.0284 0.0714 0.0714
Mycobacterium tuberculosis Carboxylesterase LipT 0.0199 0.0489 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.005 0.0091 0.0091
Leishmania major cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0087 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0005 0.0005
Schistosoma mansoni neuroligin 3 (S09 family) 0.0199 0.0489 0.0489
Trichomonas vaginalis spcc417.12 protein, putative 0.0199 0.0489 0.0484
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus acetylcholinesterase 0.1179 0.3095 0.3095
Plasmodium vivax amine transporter, putative 0.0048 0.0087 0.0079
Loa Loa (eye worm) hypothetical protein 0.0118 0.0273 0.0273
Loa Loa (eye worm) acetylcholinesterase 1 0.1179 0.3095 0.3095
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0008
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0118 0.0273 0.0265
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.3775 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.005 0.0091 0.0091
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0273 0.0273
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.0489 0.0489
Echinococcus multilocularis acetylcholinesterase 0.1179 0.3095 0.3095
Giardia lamblia Hypothetical protein 0.0118 0.0273 0.0265
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0008
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0199 0.0489 0.0484
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0015 0.0015
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0273 0.0268
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0087 0.0087
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0272
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0015 0.0015
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.3775 1 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0118 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0015
Giardia lamblia CDC72 0.3775 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Loa Loa (eye worm) norepinephrine transporter 0.0284 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0118 0.0273 0.0273
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.049 0.1263 0.1263
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0118 0.0273 0.0273
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi Carboxylesterase family protein 0.1179 0.3095 0.3095
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0118 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0284 0.0714 0.0714
Echinococcus granulosus acetylcholinesterase 0.1179 0.3095 0.3095
Trypanosoma cruzi N-myristoyl transferase, putative 0.3775 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Onchocerca volvulus 0.0199 0.0489 0.6228
Echinococcus granulosus neuroligin 0.0199 0.0489 0.0489
Loa Loa (eye worm) carboxylesterase 0.0199 0.0489 0.0489
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0048 0.0087 0.0087
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni sodium-dependent amino acid transporter 0.0048 0.0087 0.0087
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0048 0.0087 0.0087
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.0732 0.0732
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0235 0.0584 0.0577
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0235 0.0584 0.0577
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0005 0.0005
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0087 0.0087
Echinococcus multilocularis carboxylesterase 5A 0.1179 0.3095 0.3095
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi hypothetical protein 0.0199 0.0489 0.0489
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1174 0.3081 0.3081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.013 0.0306 0.1024
Echinococcus granulosus cyclin dependent kinase 19 0.1174 0.3081 0.3081
Echinococcus multilocularis neuroligin 0.0199 0.0489 0.0489
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0584 0.1981
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0005 0.0005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0087 0.0087
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0005 0.0005
Onchocerca volvulus 0.0199 0.0489 0.6228
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0284 0.0714 0.0714
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Leishmania major hypothetical protein, conserved 0.0118 0.0273 0.0265
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0005 0.0005
Trypanosoma brucei N-myristoyltransferase 0.3775 1 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0118 0.0273 0.0273
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0273 0.0265
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0272
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0118 0.0273 0.0265
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0118 0.0273 0.0273
Leishmania major N-myristoyl transferase, putative 0.3775 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0087 0.0087
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0235 0.0584 0.0577
Schistosoma mansoni BC026374 protein (S09 family) 0.0199 0.0489 0.0489
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Entamoeba histolytica cyclin C, putative 0.0809 0.211 0.2104
Treponema pallidum sodium- and chloride- dependent transporter 0.0284 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0089 0.0089
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0199 0.0489 1
Echinococcus granulosus carboxylesterase 5A 0.1179 0.3095 0.3095
Brugia malayi hypothetical protein 0.0048 0.0087 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0003
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.049 0.1263 0.1263
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0089 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0008
Echinococcus granulosus serotonin transporter 0.0284 0.0714 0.0714
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0235 0.0584 0.0577
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Onchocerca volvulus 0.0199 0.0489 0.6228
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0273 0.0265
Echinococcus granulosus potassium voltage gated channel subfamily H 0.005 0.0091 0.0091
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0101 0.0101
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.1112 0.2917 0.2917
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0087 0.0087
Schistosoma mansoni acetylcholinesterase 0.0199 0.0489 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.1174 0.3081 0.3081
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0118 0.0273 0.0273
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0273 0.0268
Echinococcus multilocularis cyclin 0.0797 0.2079 0.2079
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0273 0.0268
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0268
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0087 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0087 0.0087
Echinococcus multilocularis transient receptor potential cation channel 0.0326 0.0825 0.0825
Loa Loa (eye worm) hypothetical protein 0.1179 0.3095 0.3095
Trichomonas vaginalis N-myristoyl transferase, putative 0.3775 1 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0118 0.0273 0.0273
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0118 0.0273 0.0273
Echinococcus granulosus para nitrobenzyl esterase 0.0199 0.0489 0.0489
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0087 0.0087
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0199 0.0489 0.0489
Trichomonas vaginalis N-myristoyl transferase, putative 0.248 0.6556 0.6554
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.049 0.1263 0.1263
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0005 0.0005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0087 0.0087
Echinococcus granulosus cyclin 0.0797 0.2079 0.2079
Brugia malayi Carboxylesterase family protein 0.0199 0.0489 0.0489
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0118 0.0273 0.0912
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0087 0.0087
Echinococcus multilocularis acetylcholinesterase 0.1179 0.3095 0.3095
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0001 0.0001
Brugia malayi Pax transcription factor protein 2 0.0291 0.0732 0.0732
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0118 0.0273 0.0273
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0118 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0284 0.0714 0.0714
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.3775 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0584 0.1981
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0005 0.0005
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0118 0.0273 0.0265
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0273 0.0268

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.42 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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