Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0162 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 592 % | Agonist activity at VDR in human MG-63 cells expressing VDRE after 3 days by luciferase reporter gene based luminescence assay relative to 1,25(OH)2D3 | ChEMBL. | 23453218 |
Activity (binding) | = 3746 % | Agonist activity at VDR in human MG-63 cells expressing VDRE assessed as induction of osteocalcin production after 4 days relative to 1,25(OH)2D3 | ChEMBL. | 23453218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.