Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | urotensin 2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.227 | 0.4131 | 1 |
Schistosoma mansoni | peroxidasin | 0.227 | 0.4131 | 0.4131 |
Onchocerca volvulus | Peroxidase homolog | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | 0.227 | 0.4131 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.227 | 0.4131 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.227 | 0.4131 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.227 | 0.4131 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.4033 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.227 | 0.4131 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | 0.227 | 0.4131 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.227 | 0.4131 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.1029 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.227 | 0.4131 | 0.4131 |
Onchocerca volvulus | 0.227 | 0.4131 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Schistosoma mansoni | inositol transporter | 0.4033 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.4033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Echinococcus granulosus | peroxidasin | 0.227 | 0.4131 | 0.4131 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.4033 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.4033 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.4033 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.4033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.227 | 0.4131 | 1 |
Echinococcus multilocularis | peroxidasin | 0.227 | 0.4131 | 0.4131 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.4033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.227 | 0.4131 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1350 nM | Displacement of [125I]-U2 from human recombinant urotensin2 receptor expressed in human Chem-2 cells after 4 hrs by scintillation proximity assay | ChEMBL. | 23453841 |
IC50 (binding) | = 1450 nM | Antagonist activity at recombinant human urotensin2 receptor expressed in CHO cells assessed as inhibition of urotensin2-stimulated Ca2+ mobilization after 1 hr by FLIPR assay | ChEMBL. | 23453841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.