TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.374 | Formula: C19H20N2O2
H donors: 2 H acceptors: 2 LogP: 3.34 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)C(c1[nH]cc(n1)c1cccc(c1)OC)O
InChi: 1S/C19H20N2O2/c1-3-13-7-9-14(10-8-13)18(22)19-20-12-17(21-19)15-5-4-6-16(11-15)23-2/h4-12,18,22H,3H2,1-2H3,(H,20,21)
InChiKey: RTDKPWORFNLOGH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0885	0.3228	0.3145
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0885	0.3228	0.4731
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Schistosoma mansoni	hypothetical protein	0.0073	0.0121	0.0181
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.0958	0.3507	0.3427
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0092	0.0194	0.0074
Schistosoma mansoni	syntrophin	0.0073	0.0121	0.0181
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0121	0.0121
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.1698	0.6336	0.9465
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0885	0.3228	0.3228
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0073	0.0073
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0194	0.0111
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0092	0.0194	0.0116
Trypanosoma cruzi	hexokinase, putative	0.0953	0.3486	0.5125
Leishmania major	protein kinase, putative	0.0092	0.0194	0.0217
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0092	0.0194	0.0074
Loa Loa (eye worm)	rho-GTPase-activating	0.0073	0.0121	0.0121
Entamoeba histolytica	protein kinase 2, putative	0.1718	0.6409	0.6365
Brugia malayi	Hexokinase family protein	0.0295	0.097	0.097
Loa Loa (eye worm)	hexokinase type II	0.0953	0.3486	0.3486
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0885	0.3228	0.4731
Schistosoma mansoni	myotubularin-related protein	0.0073	0.0121	0.0181
Loa Loa (eye worm)	AGC/AKT protein kinase	0.2657	1	1
Brugia malayi	Cadps2 protein	0.0073	0.0121	0.0121
Echinococcus granulosus	protein kinase c epsilon type	0.0885	0.3228	0.4731
Brugia malayi	Dynamin	0.0073	0.0121	0.0121
Trypanosoma brucei	hexokinase	0.0953	0.3486	0.3406
Plasmodium vivax	hexokinase, putative	0.0953	0.3486	0.5352
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Brugia malayi	Hr1 repeat family protein	0.0885	0.3228	0.3228
Brugia malayi	probable spectrin beta chain	0.0073	0.0121	0.0121
Echinococcus multilocularis	hexokinase type 2	0.0953	0.3486	0.5125
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Schistosoma mansoni	serine/threonine kinase	0.0885	0.3228	0.4827
Entamoeba histolytica	protein kinase, putative	0.0092	0.0194	0.0074
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0073	0.0121	0.0181
Echinococcus granulosus	Protein kinase C brain isozyme	0.0885	0.3228	0.4731
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	hexokinase	0.0953	0.3486	0.3486
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Echinococcus granulosus	hexokinase	0.0953	0.3486	0.5125
Onchocerca volvulus		0.0598	0.2129	0.5965
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0121	0.0121
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0194	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Echinococcus granulosus	serine threonine protein kinase nrc	0.1718	0.6409	0.9576
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0092	0.0194	0.0111
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Brugia malayi	protein kinase C II.	0.0885	0.3228	0.3228
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0121	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.2584	0.9721	0.9721
Entamoeba histolytica	protein kinase, putative	0.0885	0.3228	0.3145
Entamoeba histolytica	hypothetical protein	0.0092	0.0194	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0092	0.0194	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Echinococcus granulosus	hexokinase	0.0953	0.3486	0.5125
Leishmania major	hexokinase, putative	0.0953	0.3486	1
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0121	0.0121
Trypanosoma brucei	rac serine-threonine kinase, putative	0.2657	1	1
Schistosoma mansoni	serine/threonine-protein kinase	0.179	0.6688	1
Schistosoma mansoni	dynamin	0.0073	0.0121	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Brugia malayi	Hexokinase family protein	0.0598	0.2129	0.2129
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0121	0.0181
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0073	0.0121	0.0181
Echinococcus granulosus	serine/threonine protein kinase	0.179	0.6688	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0219	0.0219
Entamoeba histolytica	protein kinase, putative	0.0092	0.0194	0.0074
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0885	0.3228	0.4731
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0073	0.0121	0.0181
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0194	0.0074
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0121	0.0121
Brugia malayi	Oxysterol-binding protein	0.0073	0.0121	0.0121
Brugia malayi	Trypsin family protein	0.0098	0.0219	0.0219
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.1718	0.6409	0.9576
Echinococcus granulosus	protein kinase c iota type	0.0885	0.3228	0.4731
Loa Loa (eye worm)	hexokinase	0.0598	0.2129	0.2129
Onchocerca volvulus		0.0087	0.0177	0.0165
Echinococcus multilocularis	rac serine:threonine kinase	0.179	0.6688	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0885	0.3228	0.3145
Trypanosoma brucei	hexokinase	0.0953	0.3486	0.3406
Brugia malayi	Pleckstrin Homology Domain	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.0885	0.3228	0.3145
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0092	0.0194	0.0116
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0866	0.3155	0.3071
Leishmania major	serine/threonine-protein kinase a, putative	0.0092	0.0194	0.0217
Echinococcus multilocularis	nervana 2	0.1698	0.6336	0.9465
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Brugia malayi	Dynamin	0.0073	0.0121	0.0121
Entamoeba histolytica	protein kinase, putative	0.0092	0.0194	0.0074
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.1718	0.6409	0.9576
Loa Loa (eye worm)	Plekhf2 protein	0.0073	0.0121	0.0121
Entamoeba histolytica	protein kinase, putative	0.0092	0.0194	0.0074
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0885	0.3228	0.3228
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Onchocerca volvulus		0.0098	0.0219	0.029
Toxoplasma gondii	protein kinase domain-containing protein	0.0092	0.0194	0.0076
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0194	0.0111
Onchocerca volvulus		0.0953	0.3486	1
Leishmania major	protein kinase, putative	0.0092	0.0194	0.0217
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0092	0.0194	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0194	0.0074
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0194	0.0111
Entamoeba histolytica	protein kinase, putative	0.0092	0.0194	0.0074
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0885	0.3228	0.4731
Echinococcus multilocularis	protein kinase c iota type	0.0885	0.3228	0.4731
Echinococcus multilocularis	hexokinase	0.0953	0.3486	0.5125
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1001	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0219	0.0219
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.1718	0.6409	1
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0121	0.0181
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0885	0.3228	0.4731
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Echinococcus granulosus	nervana 2	0.1698	0.6336	0.9465
Brugia malayi	MH2 domain containing protein	0.0144	0.0394	0.0394
Echinococcus multilocularis	Glutaredoxin protein 5	0.1698	0.6336	0.9465
Brugia malayi	MAX-1A	0.0073	0.0121	0.0121
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Loa Loa (eye worm)	PH domain-containing protein	0.0073	0.0121	0.0121
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0194	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0885	0.3228	0.3228
Echinococcus multilocularis	protein kinase c epsilon type	0.0885	0.3228	0.4731
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0885	0.3228	0.3228
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0092	0.0194	0.0074
Toxoplasma gondii	AGC kinase	0.2584	0.9721	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Trypanosoma brucei	hexokinase, putative	0.0953	0.3486	0.3406
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0073	0.0121	0.0121
Schistosoma mansoni	atypical protein kinase C	0.0885	0.3228	0.4827
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Leishmania major	folate/biopterin transporter, putative	0.0092	0.0194	0.0217
Schistosoma mansoni	serine/threonine-protein kinase	0.179	0.6688	1
Loa Loa (eye worm)	oxysterol binding protein	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.1718	0.6409	1
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0073	0.0121	0.0121
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0092	0.0194	0.0217
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0092	0.0194	0.0076
Leishmania major	hexokinase, putative	0.0953	0.3486	1
Loa Loa (eye worm)	hexokinase	0.0953	0.3486	0.3486
Loa Loa (eye worm)	hypothetical protein	0.0885	0.3228	0.3228
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0394	0.0394
Schistosoma mansoni	hypothetical protein	0.0073	0.0121	0.0181
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0885	0.3228	0.3228
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0885	0.3228	0.4731
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0073	0.0073
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0885	0.3228	0.4731
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Brugia malayi	hexokinase type II	0.0303	0.1001	0.1001
Brugia malayi	Uncoordinated protein 104	0.0073	0.0121	0.0121
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0885	0.3228	0.4731
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Entamoeba histolytica	p21-activated kinase	0.0092	0.0194	0.0074
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0885	0.3228	0.3228
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	cytohesin 3	0.0073	0.0121	0.0121
Schistosoma mansoni	hexokinase	0.0953	0.3486	0.5213
Trichomonas vaginalis	AGC family protein kinase	0.2657	1	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0121	0.0121
Treponema pallidum	hexokinase (hxk)	0.0953	0.3486	0.5
Plasmodium falciparum	hexokinase	0.0953	0.3486	0.5352
Echinococcus granulosus	protein kinase C gamma type	0.0885	0.3228	0.4731
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0885	0.3228	0.3228
Schistosoma mansoni	zinc finger protein	0.0073	0.0121	0.0181
Schistosoma mansoni	hypothetical protein	0.0073	0.0121	0.0181
Onchocerca volvulus		0.0953	0.3486	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.1698	0.6336	0.9465
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0885	0.3228	0.4731
Loa Loa (eye worm)	hypothetical protein	0.0303	0.1001	0.1001
Entamoeba histolytica	PH domain containing protein kinase, putative	0.179	0.6688	0.6647
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0194	0.0074
Brugia malayi	Oxysterol binding protein	0.0073	0.0121	0.0121
Entamoeba histolytica	protein kinase, putative	0.2584	0.9721	0.9718
Schistosoma mansoni	zinc finger protein	0.0073	0.0121	0.0181
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Brugia malayi	Syntrophin-1	0.0073	0.0121	0.0121
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.1718	0.6409	0.9576
Schistosoma mansoni	dynamin	0.0073	0.0121	0.0181
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.179	0.6688	1
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0194	0.0074
Brugia malayi	hexokinase	0.0953	0.3486	0.3486
Echinococcus granulosus	hexokinase	0.0953	0.3486	0.5125
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Entamoeba histolytica	protein kinase, putative	0.2657	1	1
Trypanosoma cruzi	hexokinase, putative	0.0953	0.3486	0.5125
Echinococcus granulosus	NDR protein kinase	0.0885	0.3228	0.4731
Brugia malayi	Cytohesin 3	0.0073	0.0121	0.0121
Loa Loa (eye worm)	hexokinase	0.0295	0.097	0.097
Echinococcus multilocularis	nervana 2	0.1698	0.6336	0.9465
Schistosoma mansoni	hypothetical protein	0.0073	0.0121	0.0181
Onchocerca volvulus	Hexokinase homolog	0.0598	0.2129	0.5965
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0121	0.0181
Echinococcus granulosus	hexokinase type 2	0.0953	0.3486	0.5125
Brugia malayi	Protein kinase domain containing protein	0.0885	0.3228	0.3228
Loa Loa (eye worm)	syntrophin-1	0.0073	0.0121	0.0121
Echinococcus granulosus	Glutaredoxin protein 5	0.1698	0.6336	0.9465
Entamoeba histolytica	hypothetical protein	0.0092	0.0194	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0194	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Schistosoma mansoni	centaurin alpha	0.0073	0.0121	0.0181
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0219	0.0327
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Echinococcus multilocularis	hexokinase	0.0953	0.3486	0.5125
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0073	0.0121	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Loa Loa (eye worm)	hypothetical protein	0.065	0.2328	0.2328
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Echinococcus multilocularis	serine threonine protein kinase	0.0885	0.3228	0.4731
Schistosoma mansoni	growth factor receptor-bound protein	0.0073	0.0121	0.0181
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0885	0.3228	0.4731
Onchocerca volvulus		0.0953	0.3486	1
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Entamoeba histolytica	hexokinase 1	0.0953	0.3486	0.3406
Schistosoma mansoni	hypothetical protein	0.0073	0.0121	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Entamoeba histolytica	hexokinase 2	0.0953	0.3486	0.3406
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0092	0.0194	0.0111
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0073	0.0073
Trypanosoma cruzi	Protein kinase B	0.179	0.6688	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0073	0.0073
Echinococcus multilocularis	hexokinase	0.0953	0.3486	0.5125
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0098	0.0219	0.0327
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Brugia malayi	Plekhf2 protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	uncoordinated protein 104	0.0073	0.0121	0.0121
Toxoplasma gondii	hexokinase	0.0953	0.3486	0.3505
Brugia malayi	p70 ribosomal S6 kinase beta	0.2584	0.9721	0.9721
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0092	0.0194	0.0217
Entamoeba histolytica	PH domain containing protein kinase, putative	0.179	0.6688	0.6647
Entamoeba histolytica	protein kinase, putative	0.2657	1	1
Brugia malayi	hypothetical protein	0.0073	0.0121	0.0121
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0194	0.0074
Trypanosoma brucei	protein kinase, putative	0.0092	0.0194	0.0074
Echinococcus granulosus	nervana 2	0.1698	0.6336	0.9465
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0121	0.0121
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0194	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0194	0.0074
Brugia malayi	Hexokinase family protein	0.0953	0.3486	0.3486
Brugia malayi	PH domain containing protein	0.0073	0.0121	0.0121
Schistosoma mansoni	serine/threonine protein kinase	0.0885	0.3228	0.4827
Schistosoma mansoni	vav2	0.0073	0.0121	0.0181
Brugia malayi	TBC domain containing protein	0.0073	0.0121	0.0121
Giardia lamblia	Kinase, AGC PKA	0.1718	0.6409	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0073	0.0121	0.0181
Echinococcus granulosus	serine:threonine protein kinase N2	0.0885	0.3228	0.4731

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2355899

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1759386