Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0158 | 0.7401 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0158 | 0.7401 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0158 | 0.7401 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0158 | 0.7401 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0158 | 0.7401 | 0.6853 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0075 | 0.1741 | 0.1741 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0158 | 0.7401 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0075 | 0.1741 | 0.1741 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0196 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0158 | 0.7401 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0158 | 0.7401 | 0.6853 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0196 | 1 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.0068 | 0.1274 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0158 | 0.7401 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0158 | 0.7401 | 0.7401 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0158 | 0.7401 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0158 | 0.7401 | 0.6853 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0158 | 0.7401 | 0.6853 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0121 | 0.4918 | 0.5614 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0189 | 0.9533 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0189 | 0.9533 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0196 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0158 | 0.7401 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0196 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0158 | 0.7401 | 0.6853 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0196 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0196 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0158 | 0.7401 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0075 | 0.1741 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.