Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0915 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1065 | 0.4168 | 0.5576 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.198 | 0.9416 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | SRC-1 | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0444 | 0.061 | 0.0817 |
Mycobacterium ulcerans | thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0726 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0898 | 0.3214 | 0.4299 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0345 | 0.0042 | 0.0056 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.4247 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0782 | 0.2547 | 0.3708 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1167 | 0.4752 | 0.6337 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Brugia malayi | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.3948 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0789 | 0.2588 | 0.3461 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1099 | 0.4361 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0884 | 0.3131 | 0.4188 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0378 | 0.0229 | 0.0306 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1167 | 0.4752 | 0.6337 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1065 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0625 | 0.1644 | 0.2199 |
Loa Loa (eye worm) | acyl carrier protein | 0.0505 | 0.096 | 0.0587 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | hypothetical protein | 0.0422 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | fatty acid synthase | 0.1084 | 0.4277 | 0.4651 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0726 | 0.2228 | 0.2981 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1167 | 0.4752 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0884 | 0.3131 | 0.4155 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1026 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1099 | 0.4361 | 0.581 |
Brugia malayi | protein-tyrosine kinase | 0.0422 | 0.0481 | 0.0481 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1099 | 0.4361 | 0.5834 |
Echinococcus multilocularis | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.0915 | 0.3311 | 0.443 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1845 | 0.8643 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.1167 | 0.4752 | 0.6357 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0884 | 0.3131 | 0.4188 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1167 | 0.4752 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1167 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.1912 | 0.9025 | 0.9562 | |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0422 | 0.0481 | 0.0481 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0713 | 0.2149 | 0.2574 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0422 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1592 | 0.1361 |
Mycobacterium ulcerans | polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1099 | 0.4361 | 0.4361 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0422 | 0.0481 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1642 | 0.7476 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1167 | 0.4752 | 0.6357 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.1026 | 0.3948 | 0.388 | |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0345 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0726 | 0.2228 | 0.2941 |
Echinococcus granulosus | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1167 | 0.4752 | 0.6357 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC0.54_uM (binding) | 2.41 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-03_Inhibitor_Dose_CherryPick_Activity. (absACnn = the concentration at which the curve crosses threshold nn uM) (Class of assay: confirmatory) | ChEMBL. | No reference |
AbsAC1 (functional) | = 14.71 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.