Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji domain containing protein | 0.1894 | 0.7752 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0458 | 0.0885 | 0.2353 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0923 | 0.3106 | 0.3006 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0303 | 0.0143 | 0.0184 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1356 | 0.5176 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0907 | 0.3031 | 0.5834 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0285 | 0.0056 | 0.0108 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0698 | 0.2032 | 0.3237 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0879 | 0.2898 | 0.5599 |
Loa Loa (eye worm) | fatty acid synthase | 0.0895 | 0.2973 | 0.4849 |
Loa Loa (eye worm) | hypothetical protein | 0.0508 | 0.1124 | 0.1681 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0963 | 0.33 | 0.6337 |
Brugia malayi | jmjC domain containing protein | 0.0556 | 0.1351 | 0.1351 |
Echinococcus granulosus | peregrin | 0.0698 | 0.2032 | 0.1917 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0923 | 0.3106 | 0.4007 |
Echinococcus granulosus | jumonji domain containing protein | 0.0972 | 0.334 | 0.3243 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.06 | 0.1562 | 0.2981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1356 | 0.5176 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.073 | 0.2183 | 0.4155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0907 | 0.3031 | 0.5834 |
Plasmodium falciparum | phd finger protein, putative | 0.0698 | 0.2032 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0879 | 0.2898 | 0.5599 |
Brugia malayi | AMP-binding enzyme family protein | 0.0279 | 0.0027 | 0.0027 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0756 | 0.2308 | 0.4459 |
Brugia malayi | jmjC domain containing protein | 0.0303 | 0.0143 | 0.0143 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.2364 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0698 | 0.2032 | 0.5984 |
Schistosoma mansoni | jumonji domain containing protein | 0.0556 | 0.1351 | 0.1743 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1635 | 0.6512 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0907 | 0.3031 | 0.5834 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0273 | 0 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.0756 | 0.2308 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0963 | 0.33 | 0.6357 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0847 | 0.2746 | 0.5305 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0907 | 0.3031 | 0.581 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0756 | 0.2308 | 0.4398 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0303 | 0.0143 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.06 | 0.1562 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0907 | 0.3031 | 0.5856 |
Loa Loa (eye worm) | hypothetical protein | 0.1275 | 0.4789 | 0.7959 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0923 | 0.3106 | 0.5077 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0698 | 0.2032 | 0.2621 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0972 | 0.334 | 0.3243 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0923 | 0.3106 | 0.4007 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0907 | 0.3031 | 0.581 |
Echinococcus multilocularis | peregrin | 0.0698 | 0.2032 | 0.1917 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.0434 | 0.05 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0963 | 0.33 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0907 | 0.3031 | 0.5856 |
Mycobacterium ulcerans | thioesterase TesA | 0.0756 | 0.2308 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.073 | 0.2183 | 0.4188 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0588 | 0.1507 | 0.4322 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0698 | 0.2032 | 0.1917 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0923 | 0.3106 | 0.3006 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0516 | 0.1159 | 0.224 |
Schistosoma mansoni | phd/f-box containing protein | 0.0303 | 0.0143 | 0.0184 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0963 | 0.33 | 0.6376 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0698 | 0.2032 | 0.1917 |
Giardia lamblia | PHD finger protein 15 | 0.0698 | 0.2032 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0847 | 0.2746 | 0.2746 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0303 | 0.0143 | 0.5 |
Loa Loa (eye worm) | acyl carrier protein | 0.0417 | 0.0688 | 0.0934 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.06 | 0.1562 | 0.2981 |
Brugia malayi | Bromodomain containing protein | 0.0698 | 0.2032 | 0.2032 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0303 | 0.0143 | 0.0184 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0742 | 0.2241 | 0.4329 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 0.2032 | 0.3237 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1356 | 0.5176 | 1 |
Onchocerca volvulus | 0.0847 | 0.2746 | 0.1593 | |
Brugia malayi | jmjC domain containing protein | 0.0303 | 0.0143 | 0.0143 |
Mycobacterium ulcerans | polyketide synthase | 0.0907 | 0.3031 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0312 | 0.0184 | 0.0356 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0556 | 0.1351 | 0.2071 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1356 | 0.5176 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.1719 | 0.6915 | 0.6915 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.598 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.1442 | 0.5587 | 0.9327 |
Onchocerca volvulus | 0.1579 | 0.6243 | 0.9399 | |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.073 | 0.2183 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0652 | 0.1809 | 0.3495 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0303 | 0.0143 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0907 | 0.3031 | 0.5856 |
Mycobacterium ulcerans | polyketide synthase | 0.0963 | 0.33 | 0.6357 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0285 | 0.0056 | 0.0056 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0556 | 0.1351 | 0.1226 |
Schistosoma mansoni | protein phosphatase 2C | 0.0303 | 0.0143 | 0.0184 |
Brugia malayi | jmjC domain containing protein | 0.0303 | 0.0143 | 0.0143 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0367 | 0.0447 | 0.0864 |
Leishmania major | hypothetical protein, conserved | 0.0303 | 0.0143 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0698 | 0.2032 | 0.5984 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0279 | 0.0027 | 0.0052 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0963 | 0.33 | 0.6376 |
Brugia malayi | jmjC domain containing protein | 0.0923 | 0.3106 | 0.3106 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.2364 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0556 | 0.1351 | 0.1226 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0646 | 0.1781 | 0.5189 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0907 | 0.3031 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0907 | 0.3031 | 0.3031 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0847 | 0.2746 | 0.446 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0963 | 0.33 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0963 | 0.33 | 0.6376 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0963 | 0.33 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0698 | 0.2032 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0698 | 0.2032 | 0.2621 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0963 | 0.33 | 0.6337 |
Brugia malayi | PHD-finger family protein | 0.0698 | 0.2032 | 0.2032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Binding affinity to TYRO3 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to TYRO3 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MET (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MET (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MER (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to MER (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to AXL (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to AXL (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 0 % | Binding affinity to non phosphorylated ABL1 (unknown origin) at 1 uM after 1 hr relative to control | ChEMBL. | 22749189 |
Activity (binding) | = 10 % | Binding affinity to non phosphorylated ABL1 (unknown origin) at 75 uM after 1 hr relative to control | ChEMBL. | 22749189 |
GI (functional) | < 10 % | Growth inhibition of human PC3 cells at 10 uM after 72 hrs by MTT assay relative to control | ChEMBL. | 22749189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.