Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0293 | 0.076 | 0.288 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.1852 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.1852 | 1 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0758 | 0.3512 | 0.3443 |
Trypanosoma cruzi | cyclin 6, putative | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclin b3 | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1852 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 0.1283 | 0.3457 | |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.061 | 0.2639 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1852 | 1 | 1 |
Mycobacterium ulcerans | thioesterase | 0.034 | 0.1038 | 0.2064 |
Trichomonas vaginalis | cyclin D, putative | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | cyclin B, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0329 | 0.0969 | 0.172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0434 | 0.1592 | 0.481 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0206 | 0.0245 | 0.0141 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.1852 | 1 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.1852 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0758 | 0.3512 | 0.3443 |
Brugia malayi | Protein kinase domain containing protein | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 0.3512 | 0.3443 |
Entamoeba histolytica | cyclin family protein | 0.0758 | 0.3512 | 0.3443 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1852 | 1 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0382 | 0.1283 | 0.4861 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.2119 | 0.2035 |
Plasmodium falciparum | protein kinase 5 | 0.1852 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.1487 | 0.1396 |
Schistosoma mansoni | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclins | 0.0758 | 0.3512 | 0.3443 |
Giardia lamblia | Kinase, CMGC CDK | 0.1852 | 1 | 1 |
Giardia lamblia | Cyclin A | 0.0758 | 0.3512 | 0.3443 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.1852 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | cyclin B, putative | 0.0758 | 0.3512 | 0.3443 |
Onchocerca volvulus | 0.0711 | 0.3235 | 0.9185 | |
Trichomonas vaginalis | cyclins, putative | 0.0758 | 0.3512 | 0.3443 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.061 | 0.2639 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0758 | 0.3512 | 0.3443 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0758 | 0.3512 | 0.3443 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.1035 | 0.094 |
Echinococcus multilocularis | cyclin b3 | 0.0758 | 0.3512 | 0.3443 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.0377 | 0.0275 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0408 | 0.1442 | 0.4065 |
Loa Loa (eye worm) | acyl carrier protein | 0.0188 | 0.0134 | 0.003 |
Echinococcus multilocularis | cyclin dependent kinase | 0.1852 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclin dependent kinase | 0.1852 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | cyclins, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0434 | 0.1592 | 0.6033 |
Leishmania major | cyclin | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.061 | 0.2639 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0334 | 0.1001 | 0.3792 |
Brugia malayi | AMP-binding enzyme family protein | 0.0382 | 0.1283 | 0.119 |
Schistosoma mansoni | cyclin d | 0.0523 | 0.2119 | 0.2035 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0408 | 0.1442 | 0.5463 |
Echinococcus multilocularis | cyclin B | 0.0758 | 0.3512 | 0.3443 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclins | 0.0758 | 0.3512 | 0.3443 |
Toxoplasma gondii | hypothetical protein | 0.0575 | 0.2428 | 0.2348 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0232 | 0.0397 | 0.1505 |
Giardia lamblia | Hypothetical protein | 0.0758 | 0.3512 | 0.3443 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0736 | 0.3385 | 0.9627 |
Trypanosoma cruzi | cyclin, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.034 | 0.1038 | 0.3934 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0408 | 0.1442 | 0.4065 |
Trichomonas vaginalis | cyclin B, putative | 0.0758 | 0.3512 | 0.3443 |
Echinococcus multilocularis | cyclin B3 1 | 0.0758 | 0.3512 | 0.3443 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.1852 | 1 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclins | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | thioesterase TesA | 0.034 | 0.1038 | 0.2064 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1852 | 1 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0265 | 0.0591 | 0.0492 |
Giardia lamblia | Kinase, CMGC CDK | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.1852 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0523 | 0.2119 | 0.2035 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0758 | 0.3512 | 0.3443 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.1852 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.1852 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.1852 | 1 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0291 | 0.0744 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.3088 | 0.3015 |
Echinococcus granulosus | cyclin B | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0434 | 0.1592 | 0.6033 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0408 | 0.1442 | 0.4065 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0408 | 0.1442 | 0.1351 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0329 | 0.0969 | 0.172 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0408 | 0.1442 | 0.5463 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.1852 | 1 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0758 | 0.3512 | 0.3443 |
Trypanosoma cruzi | cyclin, putative | 0.0758 | 0.3512 | 0.3443 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0408 | 0.1442 | 0.4065 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0758 | 0.3512 | 0.3443 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | polyketide synthase | 0.0434 | 0.1592 | 0.481 |
Entamoeba histolytica | cyclin, putative | 0.0758 | 0.3512 | 0.3443 |
Plasmodium vivax | protein kinase Crk2 | 0.1852 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1812 | 0.9762 | 0.9759 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0408 | 0.1442 | 0.5463 |
Trichomonas vaginalis | cyclin B3, putative | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.1852 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0408 | 0.1442 | 0.4065 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.1852 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | cyclins | 0.0758 | 0.3512 | 0.3443 |
Echinococcus granulosus | G1:S specific cyclin D1 | 0.0523 | 0.2119 | 0.2035 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1852 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0758 | 0.3512 | 0.3443 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0774 | 0.3609 | 0.3542 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0434 | 0.1592 | 0.481 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.1852 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.061 | 0.2639 | 1 |
Onchocerca volvulus | 0.0758 | 0.3512 | 1 | |
Echinococcus granulosus | cyclin B3 1 | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | cyclins, putative | 0.0758 | 0.3512 | 0.3443 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0758 | 0.3512 | 0.3443 |
Trichomonas vaginalis | cyclin D, putative | 0.0758 | 0.3512 | 0.3443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0396 | 0.1368 | 0.5182 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0382 | 0.1283 | 0.119 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0396 | 0.1368 | 0.5182 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0434 | 0.1592 | 0.481 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0329 | 0.0969 | 0.172 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0434 | 0.1592 | 0.481 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.1852 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0408 | 0.1442 | 0.4065 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.1852 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0758 | 0.3512 | 0.3443 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.0416 | 0.1487 | 0.1396 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0434 | 0.1592 | 0.6033 |
Trichomonas vaginalis | cyclin B, putative | 0.0758 | 0.3512 | 0.3443 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.1852 | 1 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0434 | 0.1592 | 0.1503 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0408 | 0.1442 | 0.4065 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.1852 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0434 | 0.1592 | 0.481 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.034 | 0.1038 | 0.2064 |
Loa Loa (eye worm) | fatty acid synthase | 0.0403 | 0.141 | 0.1319 |
Echinococcus granulosus | cyclin dependent kinase 6 | 0.0416 | 0.1487 | 0.1396 |
Echinococcus multilocularis | G1:S specific cyclin D1 | 0.0523 | 0.2119 | 0.2035 |
Echinococcus multilocularis | cyclins | 0.0758 | 0.3512 | 0.3443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.