Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0378 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0122 | 0.0229 | 0.0306 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.038 | 0.4787 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0296 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.038 | 0.4787 | 0.6404 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0286 | 0.3131 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0202 | 0.1644 | 0.2199 |
Onchocerca volvulus | 0.0619 | 0.9025 | 0.9285 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.038 | 0.4787 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0296 | 0.3311 | 0.443 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0531 | 0.7476 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0531 | 0.7476 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.038 | 0.4787 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0286 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0235 | 0.2228 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0356 | 0.4361 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0286 | 0.3131 | 0.4188 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0378 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0296 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0235 | 0.2228 | 0.2981 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0378 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0531 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0378 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0356 | 0.4361 | 0.5834 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.038 | 0.4787 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0332 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0144 | 0.061 | 0.0817 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0641 | 0.9416 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0351 | 0.4277 | 0.4318 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0235 | 0.2228 | 0.2981 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0253 | 0.2547 | 0.3672 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0378 | 0.4752 | 0.6357 |
Trichomonas vaginalis | hypothetical protein | 0.038 | 0.4787 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0597 | 0.8643 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0356 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0231 | 0.2149 | 0.2549 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0291 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | polyketide synthase | 0.0378 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0345 | 0.4168 | 0.5576 |
Brugia malayi | AMP-binding enzyme family protein | 0.0332 | 0.3948 | 0.3948 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.038 | 0.4787 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0356 | 0.4361 | 0.581 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.038 | 0.4787 | 0.6404 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0255 | 0.2588 | 0.3461 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0112 | 0.0042 | 0.0056 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0296 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0112 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.038 | 0.4787 | 0.6383 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0332 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0356 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0531 | 0.7476 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0378 | 0.4752 | 0.9902 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0345 | 0.4168 | 0.5576 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0356 | 0.4361 | 0.4361 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0378 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0378 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0378 | 0.4752 | 0.6337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | > 27 uM | Cytotoxicity against human HepG2 cells assessed as ATP level after 72 hrs by CellTiter-Glo assay | ChEMBL. | 23414840 |
IC50 (binding) | > 60 uM | Inhibition of VDR (unknown origin) interaction to SRC2-3 peptide by fluorescence polarization assay | ChEMBL. | 23414840 |
IC50 (binding) | > 60 uM | Inhibition of TRalpha-LBD (unknown origin) interaction to texas red-labeled SRC2-2 peptide by fluorescence polarization assay | ChEMBL. | 23414840 |
IC50 (binding) | > 60 uM | Inhibition of TRbeta-LBD (unknown origin) interaction to texas red-labeled SRC2-2 peptide by fluorescence polarization assay | ChEMBL. | 23414840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.