Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypocretin (orexin) receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | hypocretin (orexin) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | sex peptide receptor | hypocretin (orexin) receptor 1 | 425 aa | 350 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0178 | 0.473 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0111 | 0.2195 | 0.2941 |
Schistosoma mansoni | neuropeptide receptor | 0.0128 | 0.2865 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0135 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | polyketide synthase | 0.0167 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0178 | 0.473 | 0.6337 |
Echinococcus granulosus | neuropeptide receptor | 0.0128 | 0.2865 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0178 | 0.473 | 0.6337 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0156 | 0.3922 | 0.3889 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0178 | 0.473 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0178 | 0.473 | 0.6337 |
Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 0.2865 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0137 | 0.3185 | 0.4267 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0139 | 0.3283 | 0.4398 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0119 | 0.2515 | 0.3708 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0139 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0156 | 0.3922 | 0.5254 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0057 | 0.0188 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.8637 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0167 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.025 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0167 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.025 | 0.7465 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0178 | 0.473 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0301 | 0.9413 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0167 | 0.4337 | 0.0684 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0178 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0162 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0167 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0111 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0162 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0167 | 0.4337 | 0.581 |
Onchocerca volvulus | 0.0291 | 0.9021 | 0.9285 | |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.025 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0135 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | thioesterase | 0.0139 | 0.3283 | 0.4398 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0108 | 0.2116 | 0.2574 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0167 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0178 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0095 | 0.1609 | 0.2155 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0128 | 0.2865 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0178 | 0.473 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0167 | 0.4337 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1557 | 0.0823 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0178 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.012 | 0.2556 | 0.3424 |
Loa Loa (eye worm) | fatty acid synthase | 0.0165 | 0.4253 | 0.4318 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0167 | 0.4337 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0139 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0135 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0167 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0111 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.025 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0068 | 0.0571 | 0.0765 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0167 | 0.4337 | 0.581 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Antagonist activity at human OX2 receptor expressed in CHO cells assessed as inhibition of orexin A-induced calcium influx by FLIPR assay | ChEMBL. | 23434414 |
IC50 (binding) | = 1645 nM | Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of orexin A-induced calcium influx by FLIPR assay | ChEMBL. | 23434414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.