Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0211 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.0346 | 0.9025 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0113 | 0.1644 | 0.2199 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0211 | 0.4752 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0297 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0131 | 0.2228 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0297 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.008 | 0.061 | 0.0817 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0186 | 0.3948 | 0.528 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0062 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0199 | 0.4361 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0142 | 0.2547 | 0.3708 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0297 | 0.7476 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0143 | 0.2588 | 0.3461 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0199 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0211 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0211 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0186 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0131 | 0.2228 | 0.2981 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0211 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0193 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0211 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0068 | 0.0229 | 0.0306 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0131 | 0.2228 | 0.2981 |
Loa Loa (eye worm) | fatty acid synthase | 0.0196 | 0.4277 | 0.4318 |
Mycobacterium ulcerans | thioesterase TesA | 0.0166 | 0.3311 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0199 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0297 | 0.7476 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0186 | 0.3948 | 0.3948 |
Mycobacterium ulcerans | polyketide synthase | 0.0211 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.016 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0193 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0163 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0199 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0166 | 0.3311 | 0.443 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0358 | 0.9416 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0062 | 0.0042 | 0.0056 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0199 | 0.4361 | 0.4361 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0166 | 0.3311 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.8643 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0211 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0199 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0129 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.016 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.016 | 0.3131 | 0.4155 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0211 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0166 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0211 | 0.4752 | 0.6357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.03 uM | Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icilin induction measured after 5 mins by fluorescence assay | ChEMBL. | 23411075 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.