Detailed information for compound 1759644

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.335 | Formula: C17H20O9
  • H donors: 5 H acceptors: 7 LogP: -0.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@]1(O)C[C@@H](O)[C@H]([C@@H](C1)O)OC(=O)/C=C/c1ccc(c(c1)O)O
  • InChi: 1S/C17H20O9/c1-25-16(23)17(24)7-12(20)15(13(21)8-17)26-14(22)5-3-9-2-4-10(18)11(19)6-9/h2-6,12-13,15,18-21,24H,7-8H2,1H3/b5-3+/t12-,13-,15-,17+/m1/s1
  • InChiKey: SMFKCIHIAHWGGL-AWOKGZDASA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0338 0.4252 0.7475
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0086 0.0151
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0073 0.0128
Brugia malayi hypothetical protein 0.0017 0.0022 0.0022
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Schistosoma mansoni tyrosine kinase 0.0016 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0464 0.0523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.0015 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0142 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0123 0.1423 0.6477
Echinococcus granulosus nephrin 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0074 0.0769 0.0866
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Mycobacterium ulcerans Type I modular polyketide synthase 0.0409 0.5182 0.6576
Onchocerca volvulus 0.0578 0.7396 0.7784
Schistosoma mansoni neuroglian 0.0032 0.0225 0.0395
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.002 0.007 0.0079
Onchocerca volvulus 0.002 0.007 0.0073
Mycobacterium ulcerans short-chain dehydrogenase 0.0025 0.0136 0.0082
Echinococcus multilocularis neuroglian 0.0032 0.0225 0.0395
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0026 0.0142 0.0639
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0573 0.4635
Brugia malayi RNA, U transporter 1 0.008 0.0849 0.0849
Echinococcus granulosus neuroglian 0.0096 0.1059 0.1862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0289 0.0508
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0063 0.0629 0.0748
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Loa Loa (eye worm) fatty acid synthase 0.0404 0.5111 0.5755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0025 0.0136 0.0305
Onchocerca volvulus 0.0019 0.0058 0.0061
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0086 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0086 0.0086
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0086 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.002 0.007 0.0123
Loa Loa (eye worm) hypothetical protein 0.0089 0.097 0.1092
Trypanosoma cruzi oxidoreductase, putative 0.0025 0.0136 0.0305
Loa Loa (eye worm) hypothetical protein 0.0108 0.1226 0.138
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0086 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0143 0.0161
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0025 0.0136 0.0115
Onchocerca volvulus 0.0019 0.0058 0.0061
Echinococcus multilocularis titin 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Onchocerca volvulus 0.0022 0.0086 0.009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0073 0.0128
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0612 0.7843 1
Echinococcus granulosus acyl carrier protein mitochondrial 0.0041 0.0345 0.0607
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0026 0.0142 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0129 0.1496 0.1496
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0289 0.0278
Mycobacterium tuberculosis Conserved protein 0.0037 0.0289 0.0311
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0025 0.0136 0.0082
Treponema pallidum acyl carrier protein 0.0041 0.0345 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0073 0.0034
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0025 0.0136 0.0082
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0025 0.0136 0.0082
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0345 0.0335
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Onchocerca volvulus 0.0025 0.0136 0.0143
Toxoplasma gondii ABC1 family protein 0.0037 0.0289 0.0395
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0524 0.0613
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0073 0.0128
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Echinococcus granulosus titin 0.002 0.007 0.0123
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0086 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.0015 0.0027
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0129 0.1492 0.1813
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0058 0.0101
Echinococcus granulosus NADH dehydrogenase 0.0041 0.0345 0.0607
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0129 0.1492 0.1854
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.2913 0.3677
Onchocerca volvulus 0.0019 0.0058 0.0061
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0082
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0409 0.5182 0.6587
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0011 0.0013
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0323 0.4055 0.7129
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0086 0.0064
Mycobacterium ulcerans quinone oxidoreductase 0.0025 0.0136 0.0082
Echinococcus multilocularis AMP dependent ligase 0.0044 0.0385 0.0677
Echinococcus multilocularis roundabout 2 0.0032 0.0225 0.0395
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Schistosoma mansoni cell adhesion molecule 0.0032 0.0225 0.0395
Mycobacterium ulcerans Type I modular polyketide synthase 0.0409 0.5182 0.6576
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0063 0.0629 0.0716
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.0803 0.0803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0235 0.078
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0397 0.5017 0.6376
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0086 0.0017
Loa Loa (eye worm) SRC-1 0.0016 0.0015 0.0017
Echinococcus granulosus defective proboscis extension response 0.0076 0.0803 0.1412
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0063 0.0629 0.0716
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0153
Brugia malayi Disorganized muscle protein 1 0.0019 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0026 0.0142 0.0331
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0033 0.0237 0.0267
Onchocerca volvulus 0.0734 0.9451 0.9947
Mycobacterium tuberculosis Conserved protein 0.0037 0.0289 0.0311
Brugia malayi Animal haem peroxidase family protein 0.0019 0.0058 0.0058
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0225 0.0395
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0015 0.0027
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0103 0.1152 0.2026
Schistosoma mansoni acyl carrier protein 0.0041 0.0345 0.0607
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0086 0.0017
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0063 0.0629 0.0701
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0015 0.0027
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0179 0.2157 0.2429
Schistosoma mansoni ap endonuclease 0.0021 0.0073 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Loa Loa (eye worm) hypothetical protein 0.0055 0.0524 0.0591
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0225 0.0253
Mycobacterium tuberculosis Possible dehydrogenase 0.0025 0.0136 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.2157 0.3793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0524 0.0581
Mycobacterium ulcerans oxidoreductase FadB5 0.0025 0.0136 0.0082
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0086 0.0064
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0002
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.0015 0.0027
Loa Loa (eye worm) TK protein kinase 0.0343 0.431 0.4854
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0086 0.0086
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.0015 0.0027
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0086 0.0086
Echinococcus multilocularis neuroglian 0.0096 0.1059 0.1862
Onchocerca volvulus 0.0031 0.0215 0.0227
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Onchocerca volvulus Peroxidasin homolog 0.0019 0.0058 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0257 0.0452
Entamoeba histolytica protein kinase, putative 0.0179 0.2157 1
Brugia malayi Phosphopantetheine attachment site family protein 0.0041 0.0345 0.0345
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0041 0.0345 0.0607
Schistosoma mansoni cell adhesion molecule 0.0019 0.0058 0.0101
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0257 0.1365
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0103 0.1152 0.139
Schistosoma mansoni [ACP] S-malonyltransferase 0.0026 0.0142 0.0249
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0063 0.0629 0.0629
Echinococcus granulosus AMP dependent ligase 0.0044 0.0385 0.0677
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0063 0.0627 0.0745
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0025 0.0136 0.0305
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0329 0.4131 0.5223
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0073 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0044 0.0385 0.0402
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Mycobacterium ulcerans Type I modular polyketide synthase 0.0409 0.5182 0.6576
Brugia malayi SRC-1 0.0016 0.0015 0.0015
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0025 0.0136 0.0082
Onchocerca volvulus 0.0074 0.0769 0.0809
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0041 0.0345 0.0384
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0063 0.0629 0.0716
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0335 0.4202 0.533
Loa Loa (eye worm) oxidoreductase 0.0022 0.0086 0.0097
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0225 0.0395
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0165 0.1978 0.2477
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0103 0.1152 0.139
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0041 0.0345 0.0364
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0025 0.0136 0.0065
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0026 0.0142 0.0142
Mycobacterium leprae Polyketide synthase Pks13 0.0612 0.7843 1
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0086 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0345 0.0384
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0679 0.1193
Trichomonas vaginalis rotamase, putative 0.0033 0.0235 0.1204
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0063 0.0629 0.0716
Trypanosoma cruzi oxidoreductase, putative 0.0025 0.0136 0.0305
Echinococcus granulosus roundabout 2 0.0108 0.1226 0.2155
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0025 0.0136 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0769 0.0769
Entamoeba histolytica hypothetical protein 0.0023 0.01 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0032 0.0225 0.0395
Mycobacterium ulcerans oxidoreductase 0.0025 0.0136 0.0082
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.2157 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0255 0.0287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Brugia malayi Leucine Rich Repeat family protein 0.0019 0.0058 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.021 0.2561 0.4537
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0025 0.0136 0.0305
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.002
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0025 0.0136 0.0115
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0073
Onchocerca volvulus Fatty acid synthase homolog 0.0738 0.9501 1
Trypanosoma cruzi acyl transferase-like protein, putative 0.0026 0.0142 0.0331
Entamoeba histolytica hypothetical protein 0.0179 0.2157 1
Echinococcus multilocularis peroxidasin 0.0032 0.0225 0.0395
Brugia malayi Prion-like- 0.0019 0.0058 0.0058
Toxoplasma gondii type I fatty acid synthase, putative 0.0438 0.5556 1
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0019 0.0058 0.0101
Schistosoma mansoni cpg binding protein 0.0031 0.0215 0.0378
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0041 0.0345 0.2527
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0143 0.0128
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0019 0.0058 0.0101
Trypanosoma brucei acyl transferase-like protein 0.0026 0.0142 0.0331
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0192
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0025 0.0136 0.0082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0011 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0143 0.0651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0257 0.0257
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0063 0.0629 0.0748
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0323 0.4055 0.7129
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.0257 0.0884
Schistosoma mansoni septate junction protein 0.0032 0.0225 0.0395
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0019 0.0058 0.0101
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0015 0.0027
Onchocerca volvulus 0.0404 0.5113 0.5381
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0026 0.0142 0.0249
Leishmania major GTP-binding protein, putative 0.0021 0.0073 0.0002
Schistosoma mansoni alcohol dehydrogenase 0.0025 0.0136 0.0239
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0086 0.0151
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.01 0.1117 0.1373
Giardia lamblia Methyltransferase like 2 0.0123 0.1423 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0032 0.0225 0.0395
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0076 0.0803 0.1412
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0011 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Schistosoma mansoni tyrosine kinase 0.004 0.0331 0.0581
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3732 0.4203
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0019 0.0058 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Brugia malayi Protein kinase domain containing protein 0.0023 0.0106 0.0106
Echinococcus multilocularis 0.0019 0.0058 0.0101
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.0015 0.0015
Echinococcus granulosus insulin growth factor binding 0.0019 0.0058 0.0101
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0289 0.0311
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0041 0.0345 0.0389
Echinococcus multilocularis hemicentin 1 0.0032 0.0225 0.0395
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0086 0.0064
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0674 0.867 0.9763
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1362 0.1534
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0015 0.0027
Loa Loa (eye worm) one IG domain family member 0.0019 0.0058 0.0065
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0271 0.336 0.423
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Plasmodium falciparum importin beta, putative 0.0028 0.017 0.0903
Onchocerca volvulus 0.0025 0.0136 0.0143
Echinococcus granulosus titin 0.0019 0.0058 0.0101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0289 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0485 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.002 0.007 0.0123
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0026 0.0142 0.0639
Mycobacterium ulcerans polyketide synthase MbtC 0.0103 0.1152 0.139
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0289 0.0311
Schistosoma mansoni myosin-binding protein-related 0.0019 0.0058 0.0101
Plasmodium vivax acyl carrier protein, putative 0.0041 0.0345 0.2527
Loa Loa (eye worm) hypothetical protein 0.0055 0.0524 0.0591
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0103 0.1152 1
Echinococcus multilocularis insulin growth factor binding 0.0019 0.0058 0.0101
Onchocerca volvulus 0.0019 0.0058 0.0061
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0323 0.4055 0.7129
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0059 0.0573 0.4635
Echinococcus multilocularis hemicentin 1 0.0032 0.0225 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0289 0.1602
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0257 0.0452
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0086 0.0051
Echinococcus multilocularis titin 0.002 0.007 0.0123
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Mycobacterium ulcerans polyketide synthase MbtD 0.0126 0.1456 0.1781
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0044 0.0385 0.0402
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0025 0.0136 0.0065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0289 0.0508
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0063 0.0629 0.0748
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0409 0.5182 0.657
Mycobacterium ulcerans polyketide synthase Pks9 0.0271 0.336 0.423
Brugia malayi Alcohol dehydrogenase class III 0.0025 0.0136 0.0136
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0397 0.5017 0.6376
Schistosoma mansoni cell adhesion molecule 0.0032 0.0225 0.0395
Echinococcus multilocularis cpg binding protein 0.0033 0.0239 0.042
Trichomonas vaginalis esterase, putative 0.0037 0.0289 0.1602
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Brugia malayi beta-lactamase family protein 0.0037 0.0289 0.0289
Mycobacterium ulcerans beta-lactamase 0.0037 0.0289 0.0278
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0089 0.097 0.1705
Onchocerca volvulus 0.0019 0.0058 0.0061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0086 0.0097
Onchocerca volvulus 0.0019 0.0058 0.0061
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0086 0.0064
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0271 0.336 0.422
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0225 0.0253
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0086 0.0123
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.0015 0.0027
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0025 0.0136 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0257 0.0289
Loa Loa (eye worm) hypothetical protein 0.0063 0.0627 0.0706
Schistosoma mansoni cell adhesion molecule 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0627 0.0706
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0289 0.0289
Loa Loa (eye worm) animal heme peroxidase 0.0019 0.0058 0.0065
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0435 0.5517 0.7016
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0086 0.0064
Loa Loa (eye worm) hypothetical protein 0.0108 0.1226 0.138
Echinococcus multilocularis roundabout 2 0.0108 0.1226 0.2155
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0257 0.0884
Onchocerca volvulus Tyrosine kinase homolog 0.0605 0.7758 0.8165
Echinococcus granulosus leucine rich repeat containing protein 4 0.0019 0.0058 0.0101
Plasmodium falciparum acyl carrier protein 0.0041 0.0345 0.2527
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0769 0.0896
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0257 0.0452
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0041 0.0345 0.1309
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0769 0.334
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0041 0.0345 0.0384
Loa Loa (eye worm) hypothetical protein 0.0055 0.0524 0.0591
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0076 0.0803 0.1412
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0255 0.0255
Onchocerca volvulus 0.0019 0.0058 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0769 0.334
Echinococcus granulosus Immunoglobulin 0.0076 0.0803 0.1412
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0235 0.078
Echinococcus granulosus titin 0.002 0.007 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Trypanosoma brucei oxidoreductase, putative 0.0025 0.0136 0.0305
Loa Loa (eye worm) hypothetical protein 0.0055 0.0524 0.0591
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0025 0.0136 0.0115
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0179 0.2157 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0385 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0404 0.5113 0.5113
Schistosoma mansoni tyrosine kinase 0.0016 0.0015 0.0027
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0086 0.0051
Entamoeba histolytica protein kinase, putative 0.0179 0.2157 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0435 0.5517 0.7006
Echinococcus granulosus geminin 0.0338 0.4252 0.7475
Onchocerca volvulus 0.0037 0.0289 0.0304
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0141 0.1652 0.2059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0769 0.088
Loa Loa (eye worm) beta-lactamase 0.0037 0.0289 0.0325
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Echinococcus granulosus tyrosine protein kinase otk 0.0032 0.0225 0.0395
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0265 0.3292 0.5872
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0073 0.0082
Mycobacterium leprae Probable oxidireductase 0.0025 0.0136 0.0065
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0079 0.0837 0.1471
Brugia malayi Importin beta-1 subunit 0.0028 0.017 0.017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Echinococcus multilocularis down syndrome cell adhesion 0.0019 0.0058 0.0101
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0025 0.0136 0.0589
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Onchocerca volvulus 0.0022 0.0091 0.0096
Schistosoma mansoni tyrosine kinase 0.0016 0.0015 0.0027
Mycobacterium ulcerans quinone oxidoreductase 0.0025 0.0136 0.0082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0289 0.1038
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0769 0.0866
Loa Loa (eye worm) acyl carrier protein 0.0041 0.0345 0.0389
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0233 0.2861 0.361
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1362 0.1534
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.1602
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0257 0.0884
Schistosoma mansoni vesicular amine transporter 0.0076 0.0803 0.1412
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0025 0.0136 0.0115
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0063 0.0627 0.0745
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Mycobacterium ulcerans polyketide synthase 0.0409 0.5182 0.6576
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0257 0.0884
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0126 0.1456 0.1808
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0086 0.0151
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0086 0.0024
Echinococcus granulosus titin 0.0019 0.0058 0.0101
Trypanosoma brucei oxidoreductase, putative 0.0025 0.0136 0.0305
Brugia malayi Fibronectin type III domain containing protein 0.0076 0.0803 0.0803
Mycobacterium leprae Probable lipase LipE 0.0037 0.0289 0.0262
Brugia malayi hypothetical protein 0.0076 0.0803 0.0803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Echinococcus granulosus roundabout 2 0.0032 0.0225 0.0395
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0041 0.0345 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.1423 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0612 0.7843 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0025 0.0136 0.0136
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0086 0.0051
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0063 0.0627 0.0745
Schistosoma mansoni ran 0.0021 0.0073 0.0128
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.01 0.0207
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0257 0.1365
Loa Loa (eye worm) hypothetical protein 0.0229 0.2816 0.3172
Schistosoma mansoni rotamase 0.0034 0.0246 0.0432
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0103 0.1152 0.518
Onchocerca volvulus Peroxidasin homolog 0.0019 0.0058 0.0061
Schistosoma mansoni hypothetical protein 0.0034 0.0255 0.0448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0289 0.0508
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0769 0.0896
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0025 0.0136 0.0471
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Mycobacterium ulcerans fatty acid synthase Fas 0.0129 0.1492 0.1827
Mycobacterium ulcerans lipase LipD 0.0037 0.0289 0.0278
Echinococcus granulosus contactin 0.0032 0.0225 0.0395
Leishmania major zinc-binding dehydrogenase-like protein 0.0025 0.0136 0.0305
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.017 0.0468
Echinococcus granulosus cpg binding protein 0.0033 0.0239 0.042
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0025 0.0136 0.0115
Loa Loa (eye worm) acyl carrier protein 0.0188 0.2276 0.2563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0063 0.0627 0.0745
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0032 0.0225 0.0395
Brugia malayi Myb-like DNA-binding domain containing protein 0.0019 0.0058 0.0058
Echinococcus granulosus twitchin 0.0097 0.1071 0.1883
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Onchocerca volvulus 0.0063 0.0629 0.0662
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0585 0.0934
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0246 0.0277
Brugia malayi Immunoglobulin I-set domain containing protein 0.0674 0.867 0.867
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0464 0.0464
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0086 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0115 0.1312 0.5947
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0289 0.0311
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0235 0.078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0769 0.0896
Schistosoma mansoni importin beta-1 0.0028 0.017 0.0299
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0294 0.3667 0.4644
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0235 0.0296
Brugia malayi CXXC zinc finger family protein 0.0031 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0013
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0026 0.0142 0.0639
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0409 0.5182 0.6587
Echinococcus granulosus fibroblast growth factor receptor 4 0.0323 0.4055 0.7129
Echinococcus multilocularis Immunoglobulin 0.0076 0.0803 0.1412
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0225 0.0225
Loa Loa (eye worm) TK/ALK protein kinase 0.0023 0.0106 0.012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Echinococcus granulosus snurportin 1 0.0299 0.3732 0.6562
Echinococcus granulosus dnaJ subfamily B 0.0448 0.5688 1
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0026 0.0142 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0769 0.0926
Schistosoma mansoni [ACP] S-malonyltransferase 0.0026 0.0142 0.0249
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Brugia malayi Peroxidasin 0.0032 0.0225 0.0225
Schistosoma mansoni cpg binding protein 0.0033 0.0239 0.042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0215 0.0242
Mycobacterium ulcerans thioesterase TesA 0.0341 0.4285 0.5421
Trichomonas vaginalis importin beta-1, putative 0.0023 0.01 0.0207
Schistosoma mansoni septate junction protein 0.0032 0.0225 0.0395
Leishmania major zinc binding dehydrogenase-like protein 0.0025 0.0136 0.0305
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0002 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0485 0.0562
Toxoplasma gondii acyl carrier protein ACP 0.0041 0.0345 0.0498
Toxoplasma gondii type I fatty acid synthase 0.0063 0.0627 0.1012
Echinococcus multilocularis NADH dehydrogenase 0.0041 0.0345 0.0607
Brugia malayi Protein kinase domain containing protein 0.0179 0.2157 0.2157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0289 0.0311
Schistosoma mansoni cell adhesion molecule 0.0089 0.097 0.1705
Mycobacterium tuberculosis Possible dehydrogenase 0.0025 0.0136 0.0115
Brugia malayi beta-lactamase 0.0037 0.0289 0.0289
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0524 0.4184
Mycobacterium tuberculosis Hypothetical protein 0.0123 0.1423 0.1765
Echinococcus multilocularis GPCR, family 2 0.0016 0.0011 0.002
Plasmodium vivax importin-beta 2, putative 0.0028 0.017 0.0903
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0073 0.0128
Schistosoma mansoni nephrin 0.0032 0.0225 0.0395
Onchocerca volvulus Putative titin 0.0019 0.0058 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0153
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0289 0.0262
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.5688 1
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0019 0.0058 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0485 0.0562
Mycobacterium tuberculosis Conserved protein 0.0123 0.1423 0.1765
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0103 0.1152 0.518
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0025 0.0136 0.0065
Mycobacterium ulcerans thioesterase 0.0341 0.4285 0.5421
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0086 0.0086
Echinococcus granulosus roundabout 2 0.0032 0.0225 0.0395
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.007 0.007
Echinococcus granulosus hemicentin 1 0.0032 0.0225 0.0395
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0435 0.5517 0.7006
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0143 0.0337
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0025 0.0136 0.0239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0003
Schistosoma mansoni cell adhesion molecule 0.0032 0.0225 0.0395
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0025 0.0136 0.0305
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0103 0.1152 0.2026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0409 0.5182 0.6576
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0073 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Brugia malayi beta-lactamase family protein 0.0037 0.0289 0.0289
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.1602
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0629 0.0716
Echinococcus multilocularis geminin 0.0338 0.4252 0.7475
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0404 0.5113 0.6498
Echinococcus multilocularis dual specificity 0.0179 0.2157 0.3793
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0225 0.0395
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0086 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0257 0.0452
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0103 0.1152 0.518
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0063 0.0629 0.0748
Schistosoma mansoni methyltransferase-related 0.0123 0.1423 0.2502
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0435 0.5517 0.7016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0769 0.0896
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0041 0.0345 0.0384
Schistosoma mansoni tyrosine kinase 0.0323 0.4055 0.7129
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0289 0.0278
Leishmania major hypothetical protein, conserved 0.0026 0.0143 0.0337
Entamoeba histolytica acyl-CoA synthetase, putative 0.0044 0.0385 0.1498
Mycobacterium ulcerans acyl carrier protein 0.0041 0.0345 0.0351
Schistosoma mansoni hypothetical protein 0.0448 0.5688 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0025 0.0136 0.0305
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0025 0.0136 0.0082
Mycobacterium leprae Probable polyketide synthase Pks1 0.0435 0.5517 0.7001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0769 0.088
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.002
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0086 0.0064
Onchocerca volvulus Putative alcohol dehydrogenase 0.0025 0.0136 0.0143
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0179 0.2157 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0086 0.0051
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0041 0.0345 0.0607
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0086 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0769 0.0769
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0435 0.5517 0.7001
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0025 0.0136 0.0082
Onchocerca volvulus 0.0019 0.0058 0.0061
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0063 0.0627 0.0698
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0091 0.0103
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0025 0.0136 0.0239
Echinococcus multilocularis snurportin 1 0.0299 0.3732 0.6562
Echinococcus granulosus importin subunit beta 1 0.0028 0.017 0.0299
Schistosoma mansoni ran 0.0021 0.0073 0.0128
Leishmania major acyl carrier protein, putative 0.0041 0.0345 0.1309
Echinococcus multilocularis Immunoglobulin 0.0076 0.0803 0.1412
Schistosoma mansoni zinc binding dehydrogenase 0.0025 0.0136 0.0239
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0025 0.0136 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0153
Leishmania major d-xylulose reductase, putative 0.0025 0.0136 0.0305
Onchocerca volvulus 0.0037 0.0289 0.0304
Entamoeba histolytica Ran family GTPase 0.0021 0.0073 0.0002
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0246 0.0246
Leishmania major quinone oxidoreductase, putative 0.0025 0.0136 0.0305
Echinococcus multilocularis titin 0.0019 0.0058 0.0101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0032 0.0225 0.0395
Loa Loa (eye worm) hypothetical protein 0.0074 0.0769 0.0866
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0103 0.1152 1
Loa Loa (eye worm) projectin 0.0019 0.0058 0.0065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0409 0.5182 0.657
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0524 0.4184
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0143 0.0651
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0289 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0464 0.0464
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0257 0.0884
Brugia malayi hypothetical protein 0.0026 0.0143 0.0143
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.017 0.0178
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0025 0.0136 0.0153
Loa Loa (eye worm) hypothetical protein 0.069 0.888 1
Echinococcus granulosus titin 0.0019 0.0058 0.0101
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0257 0.1365
Leishmania major nuclear receptor binding factor-like protein 0.0025 0.0136 0.0305
Brugia malayi Methyltransferase-like protein 4 0.0123 0.1423 0.1423
Trypanosoma cruzi oxidoreductase, putative 0.0025 0.0136 0.0305
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0025 0.0136 0.0136
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0404 0.5113 0.5758
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0289 0.1602
Mycobacterium ulcerans hypothetical protein 0.0037 0.0289 0.0278
Loa Loa (eye worm) hypothetical protein 0.0178 0.2145 0.2416
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0086 0.0017
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0329 0.4131 0.5215
Loa Loa (eye worm) hypothetical protein 0.0178 0.2145 0.2416
Schistosoma mansoni titin 0.0019 0.0058 0.0101
Schistosoma mansoni ap endonuclease 0.0021 0.0073 0.0128
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0025 0.0136 0.0115
Brugia malayi MH2 domain containing protein 0.0119 0.1362 0.1362
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0769 0.334
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0103 0.1152 1
Echinococcus multilocularis lachesin 0.0032 0.0225 0.0395
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0289 0.1038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0086 0.0097
Echinococcus granulosus GPCR family 2 0.0016 0.0011 0.002
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0002 0.0004
Mycobacterium tuberculosis Probable thioesterase TesA 0.0341 0.4285 0.5437
Echinococcus granulosus dual specificity 0.0179 0.2157 0.3793
Echinococcus granulosus neuroglian 0.0032 0.0225 0.0395
Schistosoma mansoni titin 0.002 0.007 0.0123
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.017 0.0468
Mycobacterium ulcerans quinone reductase Qor 0.0025 0.0136 0.0082
Schistosoma mansoni cell adhesion molecule 0.0019 0.0058 0.0101
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0103 0.1152 0.1152
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0385 0.0385
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Trichomonas vaginalis rotamase, putative 0.0034 0.0246 0.1281
Mycobacterium ulcerans polyketide synthase Pks13 0.0612 0.7843 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0769 0.0896
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0143 0.0651
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0103 0.1152 0.2026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0225 0.0395
Echinococcus granulosus lachesin 0.0032 0.0225 0.0395
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0025 0.0136 0.0082
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0086 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0257 0.0452
Brugia malayi Prion-like- 0.0019 0.0058 0.0058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0769 0.0926
Trichomonas vaginalis ran, putative 0.0021 0.0073 0.0002
Schistosoma mansoni hypothetical protein 0.0299 0.3732 0.6562
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0435 0.5517 0.7001
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0086 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.0179 0.2157 1
Mycobacterium ulcerans polyketide synthase 0.0435 0.5517 0.7006
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0025 0.0136 0.0082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0257 0.0452
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0769 0.0896
Mycobacterium tuberculosis Conserved protein 0.0037 0.0289 0.0311
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.01 0.0207
Schistosoma mansoni cpg binding protein 0.0033 0.0239 0.042
Brugia malayi basement membrane proteoglycan precursor 0.0015 0.0002 0.0002
Brugia malayi kettin 0.0019 0.0058 0.0058
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0341 0.4285 0.5414
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0025 0.0136 0.0305
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0041 0.0345 0.0345
Echinococcus multilocularis titin 0.0019 0.0058 0.0101
Schistosoma mansoni hemicentin 0.0019 0.0058 0.0101
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0329 0.4131 0.5223
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.005 0.0464 0.0523
Echinococcus multilocularis twitchin 0.002 0.007 0.0123
Brugia malayi protein unc-22 0.002 0.007 0.007
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0103 0.1152 0.1298
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Schistosoma mansoni [ACP] S-malonyltransferase 0.0026 0.0142 0.0249
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0136 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0769 0.0769
Schistosoma mansoni hypothetical protein 0.0019 0.0058 0.0101
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0015 0.0027
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0025 0.0136 0.0471
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0289 0.0311
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0289 0.0311
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0019 0.0058 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.1602
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0032 0.0225 0.0395
Schistosoma mansoni nephrin 0.0096 0.1059 0.1862
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0235 0.078
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0225 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Schistosoma mansoni slit 0.0019 0.0058 0.0101
Schistosoma mansoni tyrosine kinase 0.0016 0.0015 0.0027
Leishmania major oxidoreductase, putative 0.0025 0.0136 0.0305
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0025 0.0136 0.0305
Schistosoma mansoni titin 0.0032 0.0225 0.0395
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0025 0.0136 0.0305
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0153
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.0015 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0769 0.0896
Onchocerca volvulus 0.0019 0.0058 0.0061
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0086 0.0098
Toxoplasma gondii type I fatty acid synthase, putative 0.0291 0.3632 0.6491
Echinococcus multilocularis transfer RNA-Phe 0.0019 0.0058 0.0101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0002 0.0004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.01 0.0134
Leishmania major importin beta-1 subunit, putative 0.0023 0.01 0.0134
Leishmania major oxidoreductase-like protein 0.0025 0.0136 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0246 0.1281
Mycobacterium ulcerans acyl carrier protein 0.0041 0.0345 0.0351
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0035 0.0258 0.0272
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0025 0.0136 0.0115
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0257 0.0452
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0524 0.3787
Schistosoma mansoni hypothetical protein 0.0338 0.4252 0.7475
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0025 0.0136 0.0115
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0086 0.0051
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0435 0.5517 0.7016
Echinococcus granulosus expressed protein 0.0034 0.0246 0.0432
Echinococcus multilocularis expressed protein 0.0034 0.0246 0.0432
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0409 0.5182 0.6587
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0325
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0028 0.0164 0.0288
Brugia malayi Prion-like- 0.0032 0.0225 0.0225
Trypanosoma cruzi acyl transferase-like protein 0.0026 0.0142 0.0331
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0289 0.2003
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0025 0.0136 0.0305
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0103 0.1152 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.2157 1
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0002 0.0004
Mycobacterium ulcerans hypothetical protein 0.0074 0.0769 0.0896
Mycobacterium ulcerans hypothetical protein 0.0041 0.0345 0.0351
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0103 0.1152 0.1969
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.0015 0.0027
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0015 0.0027
Loa Loa (eye worm) TK/ROR protein kinase 0.0028 0.0164 0.0185
Leishmania major hypothetical protein, conserved 0.0037 0.0289 0.1038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0028 0.0164 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0086 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0769 0.334
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0019 0.0058 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0143 0.0337
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0019 0.0058 0.0101
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0025 0.0136 0.0305
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Toxoplasma gondii acyl transferase domain-containing protein 0.0026 0.0142 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0058 0.0058
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0025 0.0136 0.0115
Loa Loa (eye worm) hypothetical protein 0.0055 0.0524 0.0591
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0058 0.0065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0343 0.431 0.431
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0289 0.1038
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0086 0.0017
Toxoplasma gondii quinone oxidoreductase, putative 0.0025 0.0136 0.0116
Echinococcus granulosus down syndrome cell adhesion 0.0019 0.0058 0.0101
Echinococcus multilocularis importin subunit beta 1 0.0028 0.017 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0769 0.334
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0235 0.078
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0103 0.1152 0.518
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0025 0.0136 0.0116
Brugia malayi Prion-like- 0.0019 0.0058 0.0058
Mycobacterium ulcerans oxidoreductase 0.0025 0.0136 0.0082
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0289 0.0508
Echinococcus multilocularis roundabout 2 0.0032 0.0225 0.0395
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0143 0.0337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Schistosoma mansoni roundabout 0.0032 0.0225 0.0395
Chlamydia trachomatis acyl carrier protein 0.0041 0.0345 0.2016
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0025 0.0136 0.0471
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0073 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0015 0.0027
Echinococcus granulosus peroxidasin 0.0032 0.0225 0.0395
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0002 0.0004
Mycobacterium ulcerans dehydrogenase 0.0025 0.0136 0.0082
Loa Loa (eye worm) hypothetical protein 0.0076 0.0803 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0257 0.1365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0485 0.0562
Onchocerca volvulus 0.0037 0.0289 0.0304
Loa Loa (eye worm) disorganized muscle protein 1 0.0019 0.0058 0.0065
Loa Loa (eye worm) CAMK protein kinase 0.002 0.007 0.0079
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0409 0.5182 0.5182
Onchocerca volvulus Netrin receptor homolog 0.0019 0.0058 0.0061
Schistosoma mansoni nephrin related 0.0019 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0257 0.0452

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 92.6 % Cytotoxicity against mouse BV2 cells assessed as cell viability at 20 uM by MTT assay ChEMBL. 23462643
IC50 (functional) = 16.57 uM Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 10 mins by Griess assay relative to control ChEMBL. 23462643
Inhibition (functional) = 13.02 % Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha production at 10 uM by ELISA ChEMBL. 25497988

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 23462643

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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